Evidence for cocaine dependence in monkeys following a prolonged period of exposure (original) (raw)

Abstract

The behavioral consequences of prolonged continuous exposure to cocaine were examined in rhesus monkeys. Operant behavior was sampled for 0.5 h every 6 h, and cocaine was continuously infused through an intravenous catheter. Cocaine (4.0–32 mg/kg/day) initially caused reductions in the rate of responding for food and tolerance developed to this effect. When the infusion of cocaine was terminated following a period of exposure during which cocaine dose was escalated to 32 mg/kg/day, there was a marked suppression of operant behavior, lasting as long as 72 h, as well as observable changes in behavior (e.g., hyporesponsiveness). This is the first demonstration of behavioral disruptions following discontinuation of cocaine exposure and suggests that the preparation will be a useful animal model for further examining the possibility that exposure to cocaine can induce dependence.

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References

• Aigner TG, Balster RL (1978) Choice behavior in rhesus monkeys: Cocaine versus food. Science 201:534–535
  Google Scholar
• Beardsley PM, Balster RL, Harris LS (1986) Dependence on tetrahydrocannabinol in rhesus monkeys. J Pharmacol Exp Ther 239:311–319
  Google Scholar
• Carroll ME, Lac ST (1987) Cocaine withdrawal produces behavioral disruptions in rats. Life Sci 40:2183–2190
  Google Scholar
• Gawin FH, Kleber HD (1986) Abstinence symptomatology and psychiatric diagnosis in cocaine abusers. Arch Gen Psychiatry 43:107–113
  Google Scholar
• Jones R (1984) The pharmacology of cocaine. In: Grabowski J (ed) Cocaine: Pharmacology, effects, and treatment of abuse. NIDA Research Monograph 50, US Government Printing Office, Washington, DC, pp 39–53
  Google Scholar
• Lewander T (1977) Effects of amphetamines in animals. In: Martin WR (ed) Drug addiction II. Springer, New York, pp 33–246
  Google Scholar
• Macphail RC, Seiden LS (1975) Time course for the effects of cocaine on fixed-ratio water-reinforced responding in rats. Psychopharmacology 44:1–4
  Google Scholar
• Post RM, Kopanda RT, Black KE (1976) Progressive effects of cocaine on behavior and central amine metabolism in rhesus monkeys: Relationship to kindling and psychosis. Biol Psychiatry 11:403–419
  Google Scholar
• Schuster CR (1968) Variables affecting the self-administration of drugs by rhesus monkeys. In: Vagtborg H (ed) Use of non-human primates in drug evaluation. University of Texas Press, Austin, TX, pp 283–299
  Google Scholar
• Slifer BL, Balster RL, Woolverton WL (1984) Behavioral dependence produced by continuous phencyclidine infusion in rhesus monkeys. J Pharmacol Exp Ther 230:399–406
  Google Scholar
• Tatum AL, Seevers MH (1929) Experimental cocaine addiction. J Pharmacol Exp Ther 36:401–410
  Google Scholar
• Wise RA (1984) Neural mechanism of the reinforcing action of cocaine. In: Grabowski J (ed) Cocaine: pharmacology, effects, and treatment of abuse. NIDA Research Monograph 50. US Government Printing Office, Washington DC, pp 15–33
  Google Scholar
• Wood DM, Emmett-Oglesby MW (1986) Characteristics of tolerance and cross-tolerance for cocaine used as a discriminative stimulus. J Pharmacol Exp Ther 237:120–125
  Google Scholar
• Woolverton WL, Kandel D, Schuster CR (1978a) Effects of repeated administration of cocaine on schedule-controlled behavior of rats. Pharmacol Biochem Behav 9:327–337
  Google Scholar
• Woolverton WL, Kandel D, Schuster CR (1978b) Tolerance and cross-tolerance to cocaine and amphetamine. J Pharmacol Exp Ther 205:525–535
  Google Scholar

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Authors and Affiliations

1. Drug Abuse Research Center, The Department of Psychiatry, Pritzker School of Medicine, The University of Chicago, 5841 S. Maryland Avenue, 60637, Chicago, IL, USA
   William L. Woolverton & Mark S. Kleven

Authors

1. William L. Woolverton
2. Mark S. Kleven

Additional information

Based in the Department of Pharmacological and Physiological Sciences, The University of Chicago, 947 East 58th Street, Chicago, IL 60637, USA

Based in the Department of Behavioral Sciences, Committee on Biopsychology, The University of Chicago, 5848 S. University, Chicago, IL 60637, USA

Offprint requests to: W.L. Woolverton at the Department of Pharmacological and Physiological Sciences

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Woolverton, W.L., Kleven, M.S. Evidence for cocaine dependence in monkeys following a prolonged period of exposure.Psychopharmacology 94, 288–291 (1988). https://doi.org/10.1007/BF00176861

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• Received: 03 August 1987
• Revised: 06 October 1987
• Issue date: February 1988
• DOI: https://doi.org/10.1007/BF00176861

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