Anaplastic (malignant) ganglioglioma arising from heterotopic grey matter nodules (original) (raw)

Summary

Anaplastic ganglioglioma is a rare malignant neoplasm. The short clinical course and the anaplastic histological features are characteristics of malignant ganglioglioma. Immunohistochemistry is necessary for the final diagnosis. The MRI appearances are described here for the first time in literature. Nodular grey matter heterotopias had been demonstrated and the patient developed an anaplastic ganglioglioma two years later, on the same place where the grey matter heteropias had been seen. This finding supports the hypothesis that these tumours may arise from grey matter nodules.

Access this article

Log in via an institution

Subscribe and save

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Discover the latest articles and news from researchers in related subjects, suggested using machine learning.

References

  1. Kleihues P, Burger PC, Scheithauer BW: Histological typing of tumours of the central nervous system. World Health Organisation, International histological classification of tumours. Springer, Berlin, Heidelberg, 1993
    Google Scholar
  2. Krouwer HGJ, Davis RL, McDermott MW, Hoshino T, fnMD: Gangliogliomas: a clinicopathological study of 25 cases and review of the literature. J Neurooncol 17: 139–154, 1993
    Google Scholar
  3. Jay V, Squire J, Becker LE, Humphreys R: Malignant transformation in a ganglioghoma with anaplastic neuronal and astrocytic components. Cancer 73: 2862–2868, 1994
    Google Scholar
  4. Rorke LB: The cerebellar medulloblastoma and its relationship to primitive neurectodermal tumours. J Neuropath Exp Neurol 42: 1–14, 1983
    Google Scholar
  5. Vanden Berg SR, May EE, Rubinstein LJ, Herman MM, Perentes E, Vinors SA, Collins P, Park TS: Desmoplastic supratentorial neuroepithelial tumors of infancy with divergent differentiation potential -(‘desmoplastic infantile gangliogliomas’). J Neurosurg 66: 58–71, 1987
    Google Scholar
  6. Russel DS, Rubinstein LJ: Tumours of central neuroepithelial origin. Ganglioneuromas (gangliocytomas) and gangliogliomas. In: Arnold E (ed) Pathology of tumours of the nervous system (5th ed). T & A Constable Ltd, Edinburgh, 1989, pp 289–306
    Google Scholar
  7. Osborn AG: Chapter 13: Astrocytomas and other glial neoplasms. In: Patterson A (ed) Diagnostic Neuroradiology. Mosby Year Book Inc., St Louis, 1994, pp 544–546
    Google Scholar
  8. Sutton LN, Wang Z, Gusnard D, Lange B, Perilongo G, Bogdan AR, Detre JA, Rorke L, Zimmerman RA: Proton magnetic resonance spectroscopy of pediatric brain tumors. Neurosurgery 31: 195–202, 1992
    Google Scholar

Download references

Author information

Authors and Affiliations

  1. Department of Radiology, Leuven, Belgium
    Philippe Demaerell, Myriam Droessaert, Guy Wilms & Albert L. Baert
  2. Department of Neuropathology, Leuven, Belgium
    Martin Lammens
  3. Department of Oncology, Leuven, Belgium
    Johan Menten
  4. Department of Neurosurgery, Leuven, Belgium
    Bart Nuttin
  5. Laboratory for Medical Imaging Research, Leuven, Belgium
    Rudy Verbeecks
  6. University Hospitals K.U.L., Leuven, Belgium
    Martin Lammens

Authors

  1. Philippe Demaerell
  2. Myriam Droessaert
  3. Martin Lammens
  4. Johan Menten
  5. Bart Nuttin
  6. Rudy Verbeecks
  7. Guy Wilms
  8. Albert L. Baert

Rights and permissions

About this article

Cite this article

Demaerell, P., Droessaert, M., Lammens, M. et al. Anaplastic (malignant) ganglioglioma arising from heterotopic grey matter nodules.J Neuro-Oncol 30, 237–242 (1996). https://doi.org/10.1007/BF00177274

Download citation

Key words