The immunologic properties of epidermal Langerhans cells as a part of the dendritic cell system (original) (raw)
References
Aiba S, Katz SI (1991) The ability of cultured Langerhans cells to process and present protein antigens is MHC dependent. J Imunol 146: 2479 Google Scholar
Barker CF, Billingham RE (1968) The role of afferent lymphatics in the rejection of skin homografts. J Exp Med 128: 197 Google Scholar
Becker D, Reske-Kunz AB, Knop J, Reske K (1991) Biochemical properties of MHC class II molecules endogenously synthesized and expressed by mouse Langerhans cells. Eur J Immunol 21: 1213 Google Scholar
Bergstresser PR, Toews GB, Streilein JW (1980) Natural and perturbed distributions of Langerhans cells: responses to ultraviolet light, heterotopic skin grafting, and dinitrofluorobenzene sensitization. J Invest Dermatol 75: 73 Google Scholar
Botham PA, Rattray NJ, Walsh ST, Riley EJ (1987) Control of the immune response to contact sensitizing chemicals by cutaneous antigen-presenting cells. Br J Dermatol 117: 1 Google Scholar
Breathnach SM (1991) Origin, cell lineage, ontogeny, tissue distribution, and kinetics of Langerhans cells. In: Schuler G (ed) Epidermal Langerhans cells. CRC Press, Boca Raton, pp 23–47 Google Scholar
Brodsky FM, Guagliardi LE (1991) The cell biology of antigen processing and presentation. Annu Rev Immunol 9: 707 Google Scholar
Bujdoso R, Hopkins J, Dutia BM, Young P, McConnell I (1989) Characterization of sheep afferent lymph dendritic cells and their role in antigen carriage. J Exp Med 170: 1285 Google Scholar
Crowley M, Inaba K, Witmer-Pack M, Steinman RM (1989) The cell surface of mouse dendritic cells: FACS analyses of dendritic cells from different tissues including thymus. Cell Immunol 118: 108 Google Scholar
Crowley M, Inaba K, Steinman RM (1990) Dendritic cells are the principal cell in mouse spleen bearing immunogenic fragments of foreign proteins. J Exp Med 172: 383 Google Scholar
Crowley MT, Inaba K, Witmer-Pack M, Gezelter S, Steinman RM (1990) Use of the fluorescence-activated cell sorter to enrich dendritic cells from mouse spleen. J Immunol Methods 133: 55 Google Scholar
Demotz S, Grey HM, Sette A (1990) The minimal number of class II MHC-antigen complexes needed for T cell activation. Science 249: 1028 Google Scholar
Faustman DL, Steinman RM, Gebel HM, Hauptfeld V, Davie JM, Lacy PE (1984) Prevention of rejection of murine islet allografts by pretreatment with anti-dendritic cell antibody. Proc Natl Acad Sci USA 81: 3864 Google Scholar
Freudenthal PS, Steinman RM (1990) The distinct surface of human blood dendritic cells, as observed after an improved isolation method. Proc Natl Acad Sci USA 87: 7698 Google Scholar
Frey JR, Wenk P (1957) Experimental studies on the pathogenesis of contac eczema in the guinea pig. Int Arch Allergy Appl Immunol 11: 81 Google Scholar
Germain RN (1991) Antigen presentation. The second class story. Nature 353: 605 Google Scholar
Girolomoni G, Simon JC, Bergstresser PR, Cruz PD Jr (1990) Freshly isolated spleen dendritic cells and epidermal Langerhans cells undergo similar phenotypic and functional changes during short term culture. J Immunol 145: 2820 Google Scholar
Hart DNJ, McKenzie JL (1986) Isolation and characterization of human tonsil dendritic cells. J Exp Med 168: 157 Google Scholar
Hauser C (1990) Cultured epidermal Langerhans cells activate effector cells for contact sensitivity. J Invest Dermatol 95: 436 Google Scholar
Hauser C, Katz SI (1988) Activation and expansion of hapten- and protein-specific T helper cells from nonsensitized mice. Proc Natl Acad Sci USA 85: 5625 Google Scholar
Heufler C, Koch F, Schuler G (1987) Granulocyte-macrophage colony-stimulating factor and interleukin-1 mediate the maturation of murine epidermal Langerhans cells into potent immunostimulatory dendritic cells. J Exp Med 167: 700 Google Scholar
Hoefsmit ECM, Duijvestijn AM, Kamperdijk WA (1982) Relation between Langerhans cells, veiled cells, and interdigitating cells. Immunobiology 161: 255 Google Scholar
Inaba K, Steinman RM (1986) Accessory cell — T lymphocyte interactions: antigen dependent and independent clustering. J Exp Med 163: 247 Google Scholar
Inaba K, Schuler G, Witmer MD, Valinsky J, Atassi B, Steinman RM (1986) The immunologic properties of purified Langerhans cells: distinct requirements for the stimulation of unprimed and sensitized T lymphocytes. J Exp Med 164: 605 Google Scholar
Inaba K, Romani N, Steinman RM (1989) An antigen-independent contact mechanism as an early step in T-cell proliferative responses to dendritic cell. J Exp Med 170: 527 Google Scholar
Inaba K, Metlay JP, Crowley MT, Steinman RM (1990) Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ. J Exp Med 172: 631 Google Scholar
Kämpgen E, Koch N, Koch F, Stöger P, Heufler C, Schuler G, Romani N (1991) Class II major histocompatibility complex molecules of murine dendritic cells: synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture. Proc Natl Acad Sci USA 88: 3014 Google Scholar
Kaplan G, Nusrat A, Witmer MD, Nath I, Cohn ZA (1987) Distribution and turnover of Langerhans cells during delayed immune responses in human skin. J Exp Med 165: 763 Google Scholar
King PD, Katz DR (1989) Human tonsillar dendritic cell-induced T-cell responses: analysis of molecular mechanisms using monoclonal antibodies. Eur J Immunol 19: 581 Google Scholar
Koch F, Heufler C, Kämpgen E, Schneeweiss D, Böck G, Schuler G (1990) Tumor necrosis factor alpha maintains the viability of murine epidermal Langerhans cells in culture but in contrast to granulocyte/macrophage colony-stimulating factor, does not induce their functional maturation. J Exp Med 171: 159 Google Scholar
Kraal G, Breel M, Janse M, Bruin G (1986) Langerhans cells, veiled cells, and interdigitating cells in the mouse recognized by a monoclonal antibody. J Exp Med 163: 981 Google Scholar
Kripke ML, Munn CG, Jeevan A, Tang J-M, Bucana C (1990) Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization. J Immunol 145: 2833 Google Scholar
Larsen CP, Morris PJ, Austyn JM (1990) Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection. J Exp Med 171: 307 Google Scholar
Larsen CP, Steinman RM, Witmer-Pack M, Hankins DF, Morris PJ, Austyn JM (1990) Migration and maturation of Langerhans cells in skin transplants and explants. J Exp Med 172: 1483 Google Scholar
Lenz A, Larsen CP, Austyn JM, Fritsch P, Romani N, Schuler G (1990) Human dermal dendritic cells: characterization by means of a novel isolation method (abstract). Arch Dermatol Res 283: 21 Google Scholar
Macatonia SE, Knight SC, Edwards AJ, Griffiths S, Fryer P (1987) Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. J Exp Med 166: 1654 Google Scholar
MacPherson GG (ed) (1989) Lymphoid dendritic cells: their life history and roles in immune responses. 28th Forum in Immunology. Res Immunol 140: 877
Will A, Blank C, Röllinghof M, Moll H (1992) Murine epidermal Langerhans cells are potent stimulators of an antigen-specific T cell response to Leishmania major, the cause of cutaneous leishmaniasis. Eur J Immunol 22: 1341 Google Scholar
Okamoto H, Kripke ML (1987) Effector and suppressor circuits of the immune response are activated in vivo by different mechanisms. Proc Natl Acad Sci USA 84: 3841 Google Scholar
Pollard AM, Lipscomp MF (1990) Characterization of murine lung dendritic cells: similarities to Langerhans cells and thymic dendritic cells. J Exp Med 172: 159 Google Scholar
Poulter LW, Campbell DA, Munro C, Janossy G (1986) Discrimination of human macrophages and dendritic cells by means of monoclonal antibodies. Scand J Immunol 24: 351 Google Scholar
Pugh CW, MacPherson GG, Steer HW (1983) Characterization of non-lymphoid cells derived from rat peripheral lymph. J Exp Med 157: 1758 Google Scholar
Puré E, Inaba K, Crowley MT, Tardelli L, Witmer-Pack MD, Ruberti G, Fathman CG, Steinman RM (1990) Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of MHC class II molecules and expression of invariant chain. J Exp Med 172: 1459 Google Scholar
Romani N, Inaba K, Witmer-Pack M, Crowley M, Puré E, Steinman RM (1989) A small number of anti-CD3 molecules on dendritic cells stimulate DNA synthesis in mouse T lymphocytes. J Exp Med 169: 1153 Google Scholar
Romani N, Koide S, Crowley M, Witmer-Pack M, Livingstone AM, Fathman CG, Inaba K, Steinman RM (1989) Presentation of exogenous protein antigens by dendritic cells to T cell clones: intact protein is presented best by immature, epidermal Langerhans cells. J Exp Med 169: 1169 Google Scholar
Romani N, Lenz A, Glassl H, Stössel H, Stanzl U, Majdic O, Fritsch P, Schuler G (1989) Cultured human Langerhans cells resemble lymphoid dendritic cells in phenotype and function. J Invest Dermatol 93: 600 Google Scholar
Romani N, Schuler G, Fritsch P (1991) Identification and phenotype of epidermal Langerhans cells. In: Schuler G (ed) Epidermal Langerhans cells. CRC Press, Boca Raton, pp 49–86 Google Scholar
Romani N, Witmer-Pack M, Crowley M, Koide S, Schuler G, Inaba K, Steinman RM (1991) Langerhans cells as immature dendritic cells. In: Schuler G (ed) Epidermal Langerhans cells. CRC Press, Boca Raton, pp 191–216 Google Scholar
Rudensky AY, Preston-Hurlburt P, Hong S-C, Barlow A, Janeway CA Jr (1991) Sequence analysis of peptides bound to MHC class II molecules. Nature 353: 622 Google Scholar
Schon-Hegrad MA, Oliver J, McMenamin PG, Holt PG (1991) Studies on the density, distribution, and surface phenotype of intraepithelial class II major histocompatibility complex antigen (Ia)-bearing dendritic cells (DC) in the conducting airways. J Exp Med 173: 1345 Google Scholar
Schuler G (ed) (1991) Epidermal Langerhans cells. CRC Press, Boca Raton Google Scholar
Schuler G, Steinman RM (1985) Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J Exp Med 161: 526 Google Scholar
Schuler G, Romani N, Stössel H, Wolff K (1991) Structural organization and biological properties of epidermal Langerhans cells. In: Schuler G (ed) Epidermal Langerhans cells. CRC Press, Boca Raton, pp 87–137 Google Scholar
Shimada S, Caughman SW, Sharrow SO, Stephany D, Katz SI (1987) Enhanced antigen-presenting capacity of cultured Langerhans cells is associated with markedly increased expression of Ia antigen. J Immunol 139: 2551 Google Scholar
Silberberg IR, Baer L, Rosenthal SA (1976) The role of Langerhans cells in allergic contact hypersensitivity. A review of findings in man and guinea pigs. J Invest Dermatol 66: 210 Google Scholar
Simon JC, Tigelaar RE, Bergstresser PR, Edelbaum D, Cruz PD Jr (1991) Ultraviolet radiation converts Langerhans cells from immunogenic to tolerogenic antigen-presenting cells. Induction of specific clonal anergy in CD4+ T helper 1 cells. J Immunol 146: 485 Google Scholar
Simon JC, Edelbaum D, Cruz PD Jr, Kapp A, Krutmann J, Schöpf E, Bergstresser PR (1992) Tumor necrosis factor-alpha (TNF: alpha) distorts the antigen-presenting function of epidermal Langerhans cells (abstract). Arch Dermatol Res 284: 69 Google Scholar
Steinman RM (1991) The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9: 271 Google Scholar
Steinman RM, Cohn ZA (1973) Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J Exp Med 137: 1142 Google Scholar
Stingl G., Shevach EM (1991) Langerhans cells as antigen presenting cells. In: Schuler G (ed) Epidermal Langerhans cells. CRC Press, Boca Raton, pp 159–190 Google Scholar
Stingl G, Katz SI, Clements L, Green I, Shevach EM (1978) Immunologic functions of Ia-bearing epidermal Langerhans cells. J Immunol 121: 2005 Google Scholar
Stössel H, Koch F, Kämpgen E, Stöger P, Lenz A, Heufler C, Romani N, Schuler G (1990) Disappearance of certain acidic organelles (endosomes and Langerhans cell granules) accompanies loss of antigen-processing capacity upon culture of epidermal Langerhans cells. J Exp Med 172: 1471 Google Scholar
Streilein JW (1989) Antigen-presenting cells in the induction of contact hypersensitivity in mice: evidence that Langerhans cells are sufficient but not required. J Invest Dermatol 93: 443 Google Scholar
Streilein JW, Grammer SF, Yoshikawa T, Demidem A, Vermeer M (1990) Functional dichotomy between Langerhans cells that present antigen to naive and to memory/effector T lymphocytes. Immunol Rev 117: 159 Google Scholar
Sullivan S, Bergstresser PR, Tigelaar RE, Streilein JW (1986) Induction and regulation of contact hypersensitivity by resident bone marrow-derived, dendritic epidermal cells: Langerhans cells and Thy-1+ epidermal cells. J Immunol 137: 2460 Google Scholar
Tang A, Udey MC (1991) Inhibition of epidermal Langerhans cell function by low-dose ultraviolet B radiation. Ultraviolet B radiation selectively modulates ICAM-1 (CD45) expressison by murine Langerhans cells. J Immunol 146: 3347 Google Scholar
Teunissen MBM, Wormmeester J, Krieg SR, Peters PJ, Vogels IMC, Kapsenberg ML, Bos JD (1990) Human epidermal Langerhans cells undergo profound morphological changes during in vitro culture. J Invest Dermatol 94: 166 Google Scholar
Toews GB, Bergstresser PR, Tigelaar RE, Streilein JW (1980) Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB. J Immunol 124: 445 Google Scholar
Tse Y, Cooper KD (1990) Cutaneous dermal Ia+ cells are capable of initiating delayed-type hypersensitivity responses. J Invest Dermatol 94: 267 Google Scholar
Weinlich G, Sepp N, Koch F, Schuler G, Romani N (1990) Evidence that Langerhans cells rapidly disappear from the epidermis in response to contact sensitizers but not to tolerogens/nonsensitizers (abstract). Arch Dermatol Res 281: 556 Google Scholar
Witmer MD, Steinman RM (1984) The anatomy of peripheral lymphoid organs with emphasis on accessory cells: light microscopic, immunocytochemical studies of mouse spleen, lymph node and Peyer's patch. Am J Anat 170: 465 Google Scholar
Witmer-Pack MD, Olivier W, Valinsky J, Schuler G, Steinman RM (1987) Granulocyte/macrophage colony-stimulating factor is essential for the viability and function of cultured murine epidermal Langerhans cells. J Exp Med 166: 1484 Google Scholar
Witmer-Pack MD, Valinsky J, Olivier W, Steinman RM (1988) Quantitation of surface antigens on cultured murine epidermal Langerhans cells: rapid and selective increase in the level of surface MHC products. J Invest Dermatol 90: 387 Google Scholar
Wolff K (1991) The fascinating story that beganin 1868. In: Schuler G (ed) Epidermal Langerhans Cells. CRC Press, Boca Raton, pp 1–21 Google Scholar
Young JW, Steinman RM (1988) Accessory cell requirements for the mixed leukocyte reaction and polyclonal mitogens, as studied with a new technique for enriching blood dendritic cells. Cell Immunol 111: 167 Google Scholar
Young JW, Koulova L, Soergel SA, Clark EA, Steinman RM, Dopont B (1992) The B7/BB1 antigen provides one of several costimulatory signals for the activation of CD4+ T lymphocytes by human blood dendritic cells in vitro. J Clin Invest 90 (in press)