Functional synaptic organization of primary visual cortex neurones in the cat (original) (raw)
Summary
The spontaneous and light evoked post-synaptic activity of cells of the primary visual cortex was investigated with intracellular and quasi-intracellular records. The resting membrane potential fluctuated mostly between 3–10 mV below the firing threshold owing to spontaneous EPSP- and IPSP-activity. Discharge activity was therefore low. Forms and amplitudes of the visible EPSP's showed a large variability, the frequency was 150–300/sec. Discrete IPSP's were between 0.5–3 mV and were less frequent than EPSP's (about 1∶10). Their duration was only slightly longer than that of EPSP's. EPSP's and IPSP's could be elicited at on or off by appropriately positioned small light stimuli. During the initial reaction following a stimulus, single PSP's could be distinguished. Geniculate on-center- as well as off-center-afferents could lead to excitation or inhibition in different neurones. The receptive fields of cortical cells to monocular stimulation were analysed with averaged records. In each neurone 2–4 overlapping areas of on- or off-activation or -inhibition could be distinguished. Each of these activation or inhibition zones had the functional properties of a single geniculo-cortical onor off-center fibre with their receptive field centers separated by 1–3°. The variety of functional organizations of the cortical neurones to monocular stimulation was explained by variable combinations of 2–4 converging geniculate on- or off-center fibres with either excitatory or inhibitory action and variable overlap of their receptive fields. This was tested in a simple computer model. — Most neurones with pronounced reactions to movement or with direction specific movement sensitivity (about half of the neurones investigated) had an excitatory contact with an off-center fibre, which seemed to be mainly responsible for the movement reaction.- The findings suggest that from each eye less than 5 geniculo-cortical afferent converging fibres have a major effect on the activity of one cortical cell. Inhibitory afferents may be indirect and relayed through another cortical pyramidal cell.
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References
- Barlow, H.B., C. Blakemore and J.D. Pettigrew: The neural mechanism of binocular depth discrimination. J. Physiol. (Lond.) 193, 327–342 (1967).
Google Scholar - Baumgartner, G., u. P. Hakas: Neurophysiologie des simultanen Helligkeitskontrastes. Pflügers Arch. ges. Physiol. 274, 489–510 (1962).
Google Scholar - —: Visual motion detection in the cat. Science 146, 1070–1071 (1964).
Google Scholar - —: Responses of single units of the cat visual system to rectangular stimulus patterns. J. Neurophysiol. 28, 1–18 (1965).
Google Scholar - Burke, R.E.: Composite nature of the monosynaptic excitatory postsynaptic potential. J. Neurophysiol. 30, 1114–1137 (1967).
Google Scholar - Burns, B.O., W. Heron and R. Pitchard: Physiological excitation of visual cortex in cat's unanaesthetized isolated forebrain. J. Neurophysiol. 25, 165–181 (1962).
Google Scholar - Colonnier, M.: The structural design of the neo-cortex. In: Brain and Conscious Experience, pp. 1–23. Ed. by J.C. Eccles. Berlin-Heidelberg-New York: Springer 1966.
Google Scholar - Creutzfeldt, O., and M. Ito: Inhibition in the visual cortex. In: Inhibition in the nervous system, pp. 343–349. Ed. by K. v. Euler. Oxford and New York: Pergamon Press 1968.
Google Scholar - —, H.D. Lux and S. Watanabe: Electrophysiology of cortical nerve cells. In: The Thalamus, pp. 209–235. Ed. by D. Purpura and M.D. Yahr. New York and London: Columbia University Press 1966.
Google Scholar - Eccles, J.C.: The physiology of synapses. Berlin-Göttingen-Heidelberg: Springer 1964.
Google Scholar - Fuster, J.M., O.D. Creutzfeldt and M. Straschill: Intracellular recording of neuronal activity in the visual system. Z. vergl. Physiol. 49, 605–622 (1965).
Google Scholar - Globus, A., and A.B. Scheibel: Synaptic loci on visual cortical neurones. I. The specificafferent radiation. Exp. Neurol. 18, 116–131 (1967a).
Google Scholar - Herz, A., O. Creutzeeldt u. J.M. Fuster: Statistische Eigenschaften der Neuronenaktivität im ascendierenden visuellen System. Kybernetik 2, 61–71 (1964).
Google Scholar - Hubel, D.H.: Integrative processes in central visual pathways of the cat. J. Opt. Soc. America 53, 58–66 (1963).
Google Scholar - Hubel, D., and T.N. Wiesel: Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. J. Physiol. (Lond.) 160, 106–154 (1962).
Google Scholar - — Shape and arrangement of columns in cat's striate cortex. J. Physiol. (Lond.) 165, 559–568 (1963).
Google Scholar - — Receptive fields and functional architecture in two non-striate visual areas (18 and 19) of the cat. J. Neurophysiol. 28, 229–289 (1965).
Google Scholar - Jung, R., R. v. Baumgarten u. G. Baumgartner: Mikroableitungen von einzelnen Nervenzellen im optischen Cortex: Die lichtaktivierten B-Neurone. Arch. Psychiat. Nervenkr. 189, 521–539 (1952).
Google Scholar - — Neuronal integration in the visual cortex and its significance for visual information. In: Sensory communication, pp. 627–674. Ed. by W. Rosenblith. New York-London: Wiley & Sons and M.I.T. Press 1961.
Google Scholar - Leyhausen, P.: Das Verhalten der Katzen (Felidae). Handb. d. Zool. 10, (21) 1–34(1956).
Google Scholar - McILWAIN, J.T., and O.D. Creutzfeldt: Microelectrode study of synaptic excitation and inhibition in the lateral geniculate nucleus of the cat. J. Neurophysiol. 30, 1–21 (1967).
Google Scholar - Mountcastle, V.B.: Modality and topographic properties of single neurones of cat's somatic sensory cortex. J. Neurophysiol. 20, 408–434 (1957).
Google Scholar - O'leary, J.T., and G.H. Bishop: The optically excitable cortex of the rabbit. J. comp. Neurol. 68, 423–478 (1937).
Google Scholar - Otsuka, R., u. R. Hassler: Über Aufbau und Gliederung der corticalen Sehsphäre der Katze. Arch. Psychiat. Nervenkr. 203, 212–234 (1962).
Google Scholar - Rall, W.: Distinguishing theoretical synaptic potentials computed for different soma-dendritic distributions of synaptic input. J. Neurophysiol. 30, 1138–1168 (1967).
Google Scholar - Ramón y Cajal, S.: Studien über die Sehrinde der Katze. J. Psychol. Neurol. (Lpz.) 29, 161–181 (1923).
Google Scholar - Rodieck, R.W., J.D. Pettigrew, P.O. Bishop and T. Nikara: Residual eye movements in receptive field studies of paralysed cats. Vision Res. 7, 107–110 (1967).
Google Scholar - —, and J. Stone: Analysis of receptive fields of cat retinal ganglion cells. J. Neurophysiol. 28, 833–849 (1965).
Google Scholar - Sholl, D.A.: The organization of the visual cortex in the cat. J. Anat. 89, 33–46 (1955).
Google Scholar - Szentágothai, J.: The anatomy of complex integrative units in the nervous system. In: Results in neuroanatomy, neurochemistry, neuropharmacology and neurophysiology, pp. 9–45. Ed. by K. Lissak. Budapest: Akademiai Kiado 1967.
Google Scholar - Watanabe, S., M. Konishi and O. Creutzfeldt: Postsynaptic potentials in the cat's visual cortex following electrical stimulation of afferent pathways. Exp. Brain Res. 1, 272–283 (1966).
Google Scholar
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- Abteilung für Neurophysiologie, Max-Planck-Institut für Psychiatrie, München, Germany
O. Creutzfeldt & M. Ito
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- O. Creutzfeldt
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This paper was partly supported by the Deutsche Forschungsgemeinschaft, which provided funds for the Lab computer IBM 1130 (Grant Cr. 30). — We are grateful to Dipl.-Ing. Probst for helping us in the computer programming.
When this manuscript was finished, a paper of Barlow et al. (1967) appeared which describes the effects of binocular stimulation on cortical neurones. Their findings of a variable disparity of the binocular inputs agree with our own observations which emphasized the variations of afferent monocular input and the variable distances of field centers of converging fibres in the different cortical neurones. — Barlow et al. also mention the fact, that stimulation of one part of a receptive area of a cortical neurone may “veto” the reaction to another stimulus. The demonstration of inhibitory areas in the receptive fields of cortical neurones is the synaptic basis for this observation.
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Creutzfeldt, O., Ito, M. Functional synaptic organization of primary visual cortex neurones in the cat.Exp Brain Res 6, 324–352 (1968). https://doi.org/10.1007/BF00233183
- Received: 12 March 1968
- Issue Date: October 1968
- DOI: https://doi.org/10.1007/BF00233183