Interaction of metoprolol with lorazepam and bromazepam (original) (raw)
Summary
The interaction between metoprolol and bromazepam and lorazepam was studied in 12 healthy male volunteers aged 21–37 years.
Metoprolol had no significant effect on the pharmacokinetics of bromazepam or lorazepam. However, bromazepam AUC was 35% higher in the presence of metoprolol. Bromazepam enhanced the effect of metoprolol on systolic blood pressure but not on diastolic blood pressure or pulse rate. Lorazepam had no effect on either blood pressure or pulse. Metoprolol did not enhance the effect of bromazepam on the psychomotor tests used in this study. Metoprolol caused a small increase in critical flicker fusion threshold with lorazepam but had no effect on the other tests. Lorazepam (2 mg) was more potent than bromazepam (6 mg) in the doses used in this study.
The interaction of metoprolol with bromazepam and lorazepam is unlikely to be of clinical significance. No change in dose is necessary when using these drugs together.
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References
- Baraka OZ, Truman CA, Ford JM, Roberts CJC (1990) The effect of propranolol on paracetamol metabolism in man. Br J Clin Pharmacol 29: 261–264
Google Scholar - Bax NDS, Lennard MS, Tucker GT (1981) Inhibition of antipyrine metabolism by β-adrenoceptor antagonists. Br J Clin Pharmacol 12: 779–784
Google Scholar - Betts TA, Knights R, Crowe A, Blake A, Harvey P, Mortiboy D (1985) Effect of β-blockers on psychomotor performance in normal volunteers. Eur J Clin Pharmacol 28 [Suppl]: 39–49
Google Scholar - Currie D, Lewis RV, McDevitt DG, Nicholson AN, Wright NA (1988) Central effects of β-adrenoceptor antagonists I — Performance and subjective assessments of mood. Br J Clin Pharmacol 26: 121–128
Google Scholar - Forfar JC, Pottage A, Toft AD, Irvine WJ, Clements JA, Prescott LF (1980) Paracetamol pharmacokinetics in thyroid disease. Eur J Clin Pharmacol 18: 269–273
Google Scholar - Hawksworth G, Betts T, Crowe A, Knight R, Nyemitei-Addo I, Parry K, Petrie JC, Raffle A, Parsons A (1984) Diazepam/β-adrenoceptor antagonist interactions. Br J Clin Pharmacol 17: 69–76S
Google Scholar - Hirayama H, Kosuya Y (1983) High performance liquid chromatographic determination of bromazepam in human plasma. J Chromat 277: 414–418
Google Scholar - Hindmarch I (1979) Effects of hypnotic and sleep inducing drugs on objective assessments of human psychomotor performance and subjective appraisals of sleep and early morning behaviour. Br J Clin Pharmacol 8: 43S-46S
Google Scholar - McDevitt DG (1985) β-blockers and psychometric performance: Studies in normal volunteers. Eur J Clin Pharmacol 28 [Suppl]: 35–38
Google Scholar - Miners JO, Attwood J, Birkett DJ (1984) Determinants of acetaminophen metabolism: effect of inducers and inhibitors of drug metabolism on acetaminophen's metabolic pathways. Clin Pharmacol Ther 35: 480–486
Google Scholar - Ochs HR, Greenblatt DJ, Verburg-Ochs B (1984) Propranolol interactions with diazepam, lorazepam and alprazolam. Clin Pharmacol Ther 36: 451–455
Google Scholar - Ochs HR, Greenblatt DJ, Friedman H, Burstein ES, Lochniskar BS, Harmatz JS, Shader RI (1987) Bromazepam pharmacokinetics: Influence of age, gender, oral contraceptives, cimetidine and propranolol. Clin Pharmacol Ther 41: 562–570
Google Scholar - Patwardhan RV, Yarborough GW, Desmond PV, Johnson RF, Schenker S, Speeg KV (1980) Cimetidine spares the gluruconidation of lorazepam and oxazepam. Gastroenterology 79: 912–916
Google Scholar - Prescott LF, Crithcley JAJH, Balali-Mood M, Pentland B (1981) Effects of microsomal enzyme induction on paracetamol metabolism in man. Br J Clin Pharmacol 12: 149–153
Google Scholar - Scott AK, Khir ASM, Steele WH, Hawksworth GM, Petrie JC (1983) Oxazepam pharmacokinetics in patients with epilepsy treated long term with phenytoin alone or in combination with phenobarbitone. Br J Clin Pharmacol 16: 441–444
Google Scholar - Scott AK, Khir ASM, Bewsher PD, Hawksworth GM (1984) Oxazepam pharmacokinetics in thyroid disease. Br J Clin Pharmacol 17: 49–53
Google Scholar
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Author notes
- A. K. Scott
Present address: Department of Pharmacology and Therapeutics, University of Liverpool, L69 3BX, Liverpool, UK
Authors and Affiliations
- Clinical Pharmacology Unit, Department of Medicine and Therapeutics, University of Aberdeen, AB9 2ZD, Aberdeen, United Kingdom
A. K. Scott, G. A. Cameron & G. M. Hawksworth
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- A. K. Scott
You can also search for this author inPubMed Google Scholar - G. A. Cameron
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Scott, A.K., Cameron, G.A. & Hawksworth, G.M. Interaction of metoprolol with lorazepam and bromazepam.Eur J Clin Pharmacol 40, 405–409 (1991). https://doi.org/10.1007/BF00265852
- Received: 16 July 1990
- Accepted: 24 October 1990
- Issue Date: April 1991
- DOI: https://doi.org/10.1007/BF00265852