Fine mapping of the Huntington disease linked D4S10 locus by non-radioactive in situ hybridization (original) (raw)

Summary

The chromosomal localization of a unique DNA fragment, closely linked to Hintington disease (HD), was assessed in situ by hybridization with 2-acetylaminofluorene (AAF) modified probes. In these experiments, a cosmid cloned genomic fragment (c5.5) was used for hybridization. Here we present evidence that confirms the mapping of the D4S10 locus to the p16 region of chromosome 4 and assigns it to the telomere of the short arm.

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Authors and Affiliations

1. Department of Histochemistry and Cytochemistry, Sylvius Laboratories, University of Leiden, P. O. Box 9503, NL-2333 AL, Leiden, The Netherlands
   J. E. Landegent, N. Jansen in de Wal & M. van der Ploeg
2. Department of Anthropogenetics, Sylvius Laboratories, University of Leiden, P. O. Box 9503, NL-2333 AL, Leiden, The Netherlands
   Y. M. Fisser-Groen, E. Bakker & P. L. Pearson

Authors

1. J. E. Landegent
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2. N. Jansen in de Wal
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3. Y. M. Fisser-Groen
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4. E. Bakker
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5. M. van der Ploeg
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6. P. L. Pearson
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Landegent, J.E., Jansen in de Wal, N., Fisser-Groen, Y.M. et al. Fine mapping of the Huntington disease linked D4S10 locus by non-radioactive in situ hybridization.Hum Genet 73, 354–357 (1986). https://doi.org/10.1007/BF00279100

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• Received: 17 March 1986
• Issue Date: August 1986
• DOI: https://doi.org/10.1007/BF00279100

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