Regional localization of the phosphoglycerate kinase gene and pseudogene on the human X chromosome and assignment of a related DNA sequence to chromosome 19 (original) (raw)
Summary
We have used a cDNA clone for human phosphoglycerate kinase (PGK) to examine the chromosomal localization of three members of the human PGK gene family. Using somatic cell hybrids segregating portions of several X-autosome translocations as well as a clone panel of hybrids segregating radiation-induced fragments of the human X chromosome, we assign a PGK pseudogene to the region Xq11–Xq13, proximal to the functional X-linked PGK gene located in Xq13. In addition, using a panel of 24 somatic cell hybrids, we assign an autosomal PGK-related DNA sequence to human chromosome 19.
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Authors and Affiliations
- Department of Medical Genetics, University of Toronto, M5S 1A8, Toronto, Ontario, Canada
H. F. Willard, M. T. Holmes & D. L. Munroe - Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE, Oxford, England
S. J. Goss
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- H. F. Willard
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Willard, H.F., Goss, S.J., Holmes, M.T. et al. Regional localization of the phosphoglycerate kinase gene and pseudogene on the human X chromosome and assignment of a related DNA sequence to chromosome 19.Hum Genet 71, 138–143 (1985). https://doi.org/10.1007/BF00283369
- Received: 01 May 1985
- Revised: 01 June 1985
- Issue Date: October 1985
- DOI: https://doi.org/10.1007/BF00283369