Mosaic trisomies in human spontaneous abortions (original) (raw)
Summary
Data from a cytogenetic survey of spontaneous abortions were examined to determine the incidence and origin of mosaic trisomies in this population. The overall frequency of mosaicism among trisomies was approximately 5%, but the level of mosaicism varied significantly among trisomies, being much higher for the nonacrocentric than for the acrocentric trisomies. Evidence from chromosome heteromorphism analysis suggests that the extra chromosome in mosaic trisomies usually has a meiotic origin.
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Authors and Affiliations
- John A. Burns School of Medicine, Department of Anatomy and Reproductive Biology, University of Hawaii, 1960 East-West Road, 96822, Honolulu, HI, USA
Terry Hassold
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This work was supported by Grant HD 07879 and Fellowship HD 05576 from the National Institutes of Health
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Hassold, T. Mosaic trisomies in human spontaneous abortions.Hum Genet 61, 31–35 (1982). https://doi.org/10.1007/BF00291327
- Received: 21 January 1982
- Revised: 19 March 1982
- Issue date: August 1982
- DOI: https://doi.org/10.1007/BF00291327