Serum intact parathyroid hormone in a random population sample of men and women: Relationship to anthropometry, life-style factors, blood pressure, and vitamin D (original) (raw)

Abstract

Intact parathyroid hormone (PTH) in serum was determined in a random population sample and was related to age, sex, body composition, life-style factors, blood pressure, blood lipids, plasma fibrinogen, and serum IGF-1, osteocalcin, and vitamin D. Within the framework of the WHO MONICA Project in the city of Göteborg, Sweden, 181 men and 166 women aged 25–64 years were studied. Intact PTH concentrations varied with age but were similar in both sexes trange 4–82 ng/liter) [mean (±SD) 23.8±10.4 ng/liter in men and 25.1±10.6 ng/liter in women]. Intact PTH concetrations increased with increasing age, body mass index, systolic blood pressure, and 1,25(OH)2D3 and decreased with increasing 25(OH)D3 in all subjects. Additionally, in men, intact PTH correlated positively to diastolic blood pressure and negatively to coffee consumption. In women, PTH also correlated negatively to smoking and IGF-1. In a multivariate analysis including all variables, age lost its significance. In both sexes there were independent positive relations between intact PTH and body mass index and 1,25(OH)2D3, and negative relations between PTH and smoking habits as well as 25(OH)D3; among men there was also negative relations between PTH and coffee consumption. The results indieate that life-style factors such as smoking and coffee consumption decrease the serum concentration of intact PTH, and the same effects is seen in individuals with low body mass index. Coffee intake, smoking, and low body mass index are also known to adversely affect bone mineral content, high-lingting the relationship between PTH and bone metabolism.

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References

  1. Nussbaum SR, Zahradnik RJ, Lavigne JR, Brennan GL, Nozawa-Ung K, Kim LY, Keutmann HT, Wang C-A, Potts Jr JT, Segre GV (1987) Highly sensitive two-site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients with hypercalcemia. Clin Chem 33:1364–1367
    Google Scholar
  2. Kuulasmaa K (1989) WHO MONICA Project: risk factors. Int J Epidemiol (suppl 1) 18:46–65
    Google Scholar
  3. Rosengren A, Tibblin G, Wilhelmsen L (1991) Self-perceived psychological stress and incidence of coronary artery disease in middle-aged men. Am J Cardiol 68:1171–1175
    Google Scholar
  4. Harmsen P, Rosengren A, Tsipogianni A, Wilhelomsen L (1990) Risk factors for stroke in a cohort of middle-aged men in Göteborg, Sweden. Stroke 21:223–229
    Google Scholar
  5. Saltin B, Grimby G (1968) Physiological analysis of middle-aged and old former athletes. Comparison with still active athletes of the same age. Circulation 38:1104–1115
    Google Scholar
  6. Allain CC, Poon LS, Chan CS, Richmond W, Fu PC (1974) Enzymatic determination of total serum cholesterol. Clin Chem 20:470–475
    Google Scholar
  7. Warnick GR, Benderson J, Albers JJ (1982) Dextran Sulfate-Mg2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol. Clin Chem 28:1379–1388
    Google Scholar
  8. Fossati P, Prencipe L (1982) Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin Chem 28:2077–2080
    Google Scholar
  9. von Clauss A (1957) Gerinnerungsphysiologishche Schnellmethode zur Bestimmung des Fibrinogens. Acta Haematol 17:237–246
    Google Scholar
  10. Brickman A, Nyby M, von Hungen K, Eggena P, Tuck M (1991) Parathyroid hormone, platelet calcium, and blood pressure in normotensive subjects. Hypertension 18:176–182
    Google Scholar
  11. Sherman SS, Hollis BW, Tobin JD (1990) Vitamin D status and related parameters in a healthy population: the effects of age, sex and season. J Clin Endocrinol Metab 71:405–413
    Google Scholar
  12. Endres DB, Morgan CH, Garry PJ, Omdahl JL (1987) Agerelated changes in serum immunoreactive parathyroid hormone and its biological action in healthy men and women. J Clin Endocrinol Metab 65:724–731
    Google Scholar
  13. Marcus R, Madvig P, Young G (1984) Age-related changes in parathyroid hormone and parathyroid hormone action in normal humans. J Clin Endocrinol Metab 58:223–230
    Google Scholar
  14. Chapuy MC, Durr F, Chapuy P (1983) Age-related changes in parathyroid hormone and 25 hydroxycholecalciferol levels. J Gerontol 38:19–22
    Google Scholar
  15. Riggs BL, Melton LJ (1986) Involutional osteoporosis. N Engl J Med 314:1676–1686
    Google Scholar
  16. Havarfner A, Ljunghall S, Mörlin C, Wide L, Bergström R (1986) Indices of mineral metabolism in relation to blood pressure in a sample of a healthy population. Acta Med Scand 219:461–468
    Google Scholar
  17. Mellström D, Johansson C, Johnell O, Lindstedt G, Lundberg P-A, Obrant K, Schöön I-M, Toss G, Ytterberg B-O (1993) Osteoporosis, metabolic aberrations and increased risk for vertebral fractures after partial gastrectomy. Calcif Tissue Int 53: 370–377
    Google Scholar
  18. Johansson C, Mellström D, Lerner U, Österberg T (1992) Coffee drinking: a minor risk factor for bone loss and fractures. Age Ageing 21:20–26
    Google Scholar
  19. Barret-Connor E, Chun Chang J, Edelstein SL (1994) Coffee-associated osteoporosis offset by daily milk consumption. The Rancho Bernardo Study. JAMA 271:280–283
    Google Scholar

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Authors and Affiliations

  1. Department of Medicine, University of Göteborg, Göteborg, Sweden
    K. Landin-Wilhelmsen, T. Rosén, J. Wilske & B. -Å. Bengtsson
  2. Department of Heart and Lung Diseases, University of Göteborg, Göteborg, Sweden
    L. Wilhelmsen & G. Lappas
  3. Department of Clinical Chemistry, University of Göteborg, Göteborg, Sweden
    G. Lindstedt & P. -A. Lundberg

Authors

  1. K. Landin-Wilhelmsen
  2. L. Wilhelmsen
  3. G. Lappas
  4. T. Rosén
  5. G. Lindstedt
  6. P. -A. Lundberg
  7. J. Wilske
  8. B. -Å. Bengtsson

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The WHO MONICA Project in Göteborg.

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Landin-Wilhelmsen, K., Wilhelmsen, L., Lappas, G. et al. Serum intact parathyroid hormone in a random population sample of men and women: Relationship to anthropometry, life-style factors, blood pressure, and vitamin D.Calcif Tissue Int 56, 104–108 (1995). https://doi.org/10.1007/BF00296339

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