Development of the origin of the coronary arteries, a matter of ingrowth or outgrowth? (original) (raw)

• A. C. Gittenberger-de Groot2,

• R. E. Poelmann2,

• B. M. Péault3 &

• …

• H. A. Huysmans4

• 321 Accesses

• 252 Citations

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Summary

Inconsistencies still exist with regard to the exact mode of development of proximal coronary arteries and coronary orifices. In this regard 15 quail embryos were investigated using a monoclonal anti-endothelium antibody, enabling a detailed study of the development of endothelium-lined vasculature. Coronary orifices emerged at 7–9 days of incubation (Zacchei stages 24–26) and were invariably present at 10 days of incubation (Zacchei stage 27).

We never observed more than 2 coronary orifices; these were always single in either of the facing sinuses of the aorta. A coronary orifice was always observed being connected to an already developed proximal coronary artery, which belonged to a peritruncal ring of coronary arterial vasculature. We did not find any coronary orifice without a connection to a proximal coronary artery. Moreover, at 7–9 days of incubation (Zacchei stages 24–26) we observed coronary arteries from the peritruncal ring penetrating the aortic media. In 2 specimen this coronary artery, with a lumen, was in contact with the still intact endothelial lining of the aorta.

We conclude that coronary arteries do not grow out of the aorta, but grow into the aorta from the peritruncal ring of coronary arterial vasculature. This throws new light on normal and abnormal development of proximal coronary arteries and coronary orifices.

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References

• Abrikosoff A (1911) Aneurysma des linken Ventrikels mit abnormer Abgangstelle der linken Koronararterie von der Pulmonalis bei einem fünfmonatlichen Kinde. Virchows Arch Pathol Anat 2203:413–420
  Google Scholar
• Aikawa E, Kawano J (1982) Formation of coronary arteries sprouting from the primitive aortic sinus wall of the chick embryo. Experientia 38:816–818
  Google Scholar
• Bartelings MM, Gittenberger-de Groot (1988) The arterial orifice level in the early human embryo. Anat Embryol 177:537–542
  Google Scholar
• Bland EF, White PD, Garland J (1933) Congenital anomalies of the coronary arteries: report of an unusual case associated with cardiac hypertrophy. Am Heart J 8:787–801
  Google Scholar
• Bogers AJJC, Gittenberger-de Groot AC, Dubbeldam JA, Huysman HA (1988a) The inadequacy of existing theories on development of the proximal coronary arteries and their connections with the arterial trunks. Int J Cardiol 20:117–123
  Google Scholar
• Bogers AJJC, Quaegebeur JM, Huysmans HA (1988b) The need for follow-up after surgical correction of anomalous left coronary artery arising from the pulmonary artery. J Cardiovasc Surg 29:339–342
  Google Scholar
• Corone P, Corone A, Dor X, Binet JP (1984) Les artères coronaires et leurs variations, une explication embryologique. C R Acad Sc Paris 299 [III]:451–458
  Google Scholar
• Dbaly J, Ostadal B, Rychter Z (1968) Development of the coronary arteries in rat embryos. Acta Anat 71:209–222
  Google Scholar
• Gittenberger-de Groot AC, Sauer U, Oppenheimer-Dekker A, Quaegebeur JM (1983) Coronary arterial anatomy in transposition of the great arteries: a morphological study. Pediatr Cardiol 4 [Suppl 1]:15–24
  Google Scholar
• Gittenberger-de Groot AC, Bogers AJJC, Bartelings MM (1987) Aspects of normal and abnormal development of the main coronary arteries. In: Spaan JAE, Bruschke AVG, Gittenberger-de Groot AC (eds) Coronary circulation. Dordrecht, Nyhoff, pp 32–42
  Google Scholar
• Hackensellner A (1956) Akzessorische Kranzgefäßanlagen der Arteria pulmonalis unter 63 menschlichen Embryonen-Serien mit einer größten Länge von 12 bis 36 mm. Z Mikrosk Anat Forsch 62:153–164
  Google Scholar
• Heintzberger CFM (1983) Development of myocardial vascularization in the rat. Acta Morphol Neerl Scand 21:267–284
  Google Scholar
• Hirakow R (1983) Development of the cardiac blood vessels in staged human embryos. Acta Anat 15:220–230
  Google Scholar
• Hutchins GM, Kessler-Hanna A, Moore GW (1988) Development of the coronary arteries in the embryonic human heart. Circulation 77:1250–1257
  Google Scholar
• Labastie MC, Poole TJ, Péault BM, Le Douarin NM (1986) MB1, a quail leukocyte-endothelium antigen: partial characterization of the cell surface and secreted forms in cultured endethelial cells. Proc Natl Acad Sci USA 83:9016–9020
  Google Scholar
• Ogden JA (1988) The origin of the coronary arteries [Abstr]. Circulation 38[Suppl 4]:150
  Google Scholar
• Péault BM (1987) MB1, a quail leukocyte/vascular endothelium antigen: characterization of the lymphocyte-surface form and identification of its secreted counterpart as alpha-2-macroglobulin. Cell Differ 21:175–187
  Google Scholar
• Péault BM, Thiery JP, Le Douarin NM (1983) Surface marker for hemopoietic and endothelial cell lineages in quail that is defined by a monoclonal antibody. Proc Natl Acad Sci USA 80:2976–2980
  Google Scholar
• Péault BM, Coltey M, Le Douarin NM (1988) Ontogenic emergence of a quail leukocyte/endothelium cell surface antigen. Cell Differ 23:165–174
  Google Scholar
• Quaegebeur JM, Rohmer J, Ottenkamp J, Buis T, Kirklin JW, Blackstone EH, Brom AG (1986) The arterial switch operation, an eight-year experience. J Thor Cardiovasc Surg 92:361–384
  Google Scholar
• Zacchei AM (1961) Sviluppo embrionale della quaglia giapponese (Coturnix coturnix japonica). Arch Ital Anat Embriol 66:36–63
  Google Scholar
• Zuber M, Wortmann J (1984) Untersuchung zur Entwicklung des Koronargefäßsystems bei der Maus. Verh Anat Ges 78:269–270
  Google Scholar

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Authors and Affiliations

1. Department of Thoracic Surgery, Thoraxcenter, University Hospital Dijkzigt, Rotterdam, The Netherlands
   A. J. J. C. Bogers
2. Department of Anatomy and Embryology, State University, Leiden, The Netherlands
   A. J. J. C. Bogers, A. C. Gittenberger-de Groot & R. E. Poelmann
3. Institut d'Embryologie du CNRS et du College de France, Nogent-sur-Marne, France
   B. M. Péault
4. Department of Thoracic Surgery, University Hospital, Leiden, The Netherlands
   H. A. Huysmans

Authors

1. A. J. J. C. Bogers
2. A. C. Gittenberger-de Groot
3. R. E. Poelmann
4. B. M. Péault
5. H. A. Huysmans

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Bogers, A.J.J.C., Gittenberger-de Groot, A.C., Poelmann, R.E. et al. Development of the origin of the coronary arteries, a matter of ingrowth or outgrowth?.Anat Embryol 180, 437–441 (1989). https://doi.org/10.1007/BF00305118

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• Accepted: 13 June 1989
• Issue date: October 1989
• DOI: https://doi.org/10.1007/BF00305118

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