Abnormal cytoskeletal pathology peculiar to corticobasal degeneration is different from that of Alzheimer's disease or progressive supranuclear palsy (original) (raw)

Abstract

An autopsy case of clinically diagnosed “corticobasal degeneration (CBD)” was investigated. In addition to status spongiosus and neuronal achormasia around the central sulcus, cortical pyramidal neurons and thread-like structures were densely stained by Gallyas stain and tau immunohistochemistry, but apparent fibrillary structures like Alzheimer's disease neurofibrillary tangle were absent. Bodian, methenamine-Bodian, Congo red, thioflavin S, or Bielshowsky stains failed to visualize these structures. They were not stained by immunohistochemical stain with anti-ubiquitin antibody. The widespread cytoskeletal pathology, which is distinct from that in Alzheimer's disease or progressive supranuclear palsy, is suggestive of CBD.

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Authors and Affiliations

  1. Department of Neurology, Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, 113, Bunkyo-ku, Tokyo, Japan
    Toshiki Uchihara, Kazuko Mitani & Masahito Yamada
  2. Department of Neurology, Kakeyu Rehabilitation Center Hospital, 1308 Nishiuchi, Maruko-machi, Chiisagata-gun, 386-03, Nagano, Japan
    Kazuko Mitani
  3. Department of Psychiatry, Asai Hospital, 38 Yatoku, 283, Tougane-City, Chiba, Japan
    Hiroshi Mori
  4. Department of Neuropathology, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa, 156, Setagaya-ku, Tokyo, Japan
    Toshiki Uchihara, Hiromi Kondo & Kenji Ikeda

Authors

  1. Toshiki Uchihara
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  2. Kazuko Mitani
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  3. Hiroshi Mori
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  4. Hiromi Kondo
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  5. Masahito Yamada
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  6. Kenji Ikeda
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Uchihara, T., Mitani, K., Mori, H. et al. Abnormal cytoskeletal pathology peculiar to corticobasal degeneration is different from that of Alzheimer's disease or progressive supranuclear palsy.Acta Neuropathol 88, 379–383 (1994). https://doi.org/10.1007/BF00310383

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