Maternal aggression in rats: Lack of interaction between chlordiazepoxide and fluprazine (original) (raw)

Abstract

In a paradigm of female aggression, maternal aggression, low doses of chlordiazepoxide (CDP) enhanced aggression, whereas the serenic drug fluprazine dose-dependently decreased aggression.

In this study one selected dose of CDP (5 mg/kg PO) clearly enhanced aggression of female lactating rats against a naive male intruder. This dose of CDP however, was not able to antagonize the dose-dependent decrease observed after fluprazine treatment (5, 10, 20 mg/kg IP). These data suggest that fluprazine and CDP do not simply have opposite effects at the same site of action. It is suggested that fluprazine decreased the offensive motivation of animals, whereas CDP increased attacks indirectly by reduction of the approach-avoidance conflict in a social context.

Access this article

Log in via an institution

Subscribe and save

• Starting from 10 chapters or articles per month
• Access and download chapters and articles from more than 300k books and 2,500 journals
• Cancel anytime View plans

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

• Arnone M, Dantzer R (1980) Effects of diazepam on extinction induced aggression in pigs. Pharmacol Biochem Behav 13:27–30
  Google Scholar
• Benton D, Brain PF, Jones S, Colebrook E, Grimm V (1983) Behavioural examinations of the anti-aggressive drug Fluprazine. Behav Brain Res 10:325–338
  Google Scholar
• Blanchard DC, Takushi R, Blanchard RJ, Flannelly KJ, Kemble ED (1985) Fluprazine hydrochloride does not decrease defensive behaviors of wild and septal syndrome rats. Physiol Behav (in press)
• Bradford LD, Olivier B, Van Dalen D, Schipper J (1984) Serenics: the pharmacology of fluprazine and DU 28412. In: Miczek KA, Kruk MR, Olivier B (eds) Ethopharmacological aggression research, Alan R. Liss, Inc, New York, pp 191–208
  Google Scholar
• File SE, Hyde JRG (1978) Can social interaction be used to measure anxiety? Br J Pharmacol 62:19–24
  Google Scholar
• Krsiak M (1979) Effects of drugs on behaviour of aggressive mice. Br J Pharmacol 65:525–533
  Google Scholar
• Krsiak M, Sulcova A, Tomasikova Z, Dlohozkova N, Kosar E, Masek K (1981) Drug effects on attack, defense and escape in mice. Pharmacol Biochem Behav 14 (Suppl 1):47–52
  Google Scholar
• Miczek KA (1974) Intraspecies aggression in rats: effects of _d_-amphetamine and chlordiazepoxide. Psychopharmacologia 39:275–301
  Google Scholar
• Miczek KA, O'Donnell JM (1980) Alcohol and chlordiazepoxide increase suppressed aggression in mice. Psychopharmacology 69:39–44
  Google Scholar
• Olivier B, Van Dalen D (1982) Social behaviour in rats and mice: an ethologically based model for differentiating psychoactive drugs. Aggress Behav 8:163–168
  Google Scholar
• Olivier B, van Aken H, Jaarsma I, van Oorschot R, Zethof T, Bradford LD (1984a) Behavioural effects of psychoactive drugs on agonistic behaviour of male territorial rats (resident-intruder model). In: Miczek KA, Kruk MR, Olivier B (eds) Ethopharmacological aggression research, Alan R Liss, Inc, New York, pp 137–156
  Google Scholar
• Olivier B, Mos J, Van der Poel AM, Krijzer FNC, Kruk MR (1984b) Effect of a new psychoactive drug (DU 27716) on different models of agonistic behaviour and EEG. In: Blanchard DC, Flannelly KJ, Blanchard RJ (eds) Biological perspectives on aggression, Alan R Liss, Inc, New York, pp 261–279
  Google Scholar
• Olivier B, Mos J, Van Oorschot R (1985) Maternal aggression in rats: effects of chlordiazepoxide and fluprazine. Psychopharmacology 86:68–76
  Google Scholar
• Racine MA, Flannelly KJ, Blanchard DC (1984) Anti-aggressive effects of DU 27716 on attack and defensive behaviors in male mice. In: Blanchard DC, Flannelly KJ, Blanchard RJ (eds) Biological perspectives on aggression, Alan R Liss, Inc, New York, pp 281–293
  Google Scholar
• Van der Poel AM, Olivier B, Mos J, Kruk MR, Meelis W, Van Aken JHM (1982) The anti-aggressive effect of a new phenylpiperazine compound (DU 27716) on hypothalamically induced behavioural activities. Pharmacol Biochem Behav 17:147–153
  Google Scholar

Download references

Author information

Authors and Affiliations

1. Department of Pharmacology, Duphar B.V., P.O. Box 2, 1380 AA, Weesp, The Netherlands
   Berend Olivier & Ruud van Oorschot
2. Institute for Experimental Gerontology, Lange Kleiweg 151, 2280 HV, Rijswijk, The Netherlands
   Jan Mos

Authors

1. Berend Olivier
2. Jan Mos
3. Ruud van Oorschot

Rights and permissions

About this article

Cite this article

Olivier, B., Mos, J. & van Oorschot, R. Maternal aggression in rats: Lack of interaction between chlordiazepoxide and fluprazine.Psychopharmacologia 88, 40–43 (1986). https://doi.org/10.1007/BF00310510

Download citation

• Received: 01 May 1985
• Revised: 17 July 1985
• Issue date: January 1986
• DOI: https://doi.org/10.1007/BF00310510

Key words