Yeast SCO1 protein is required for a post-translational step in the accumulation of mitochondrial cytochrome c oxidase subunits I and II (original) (raw)
Summary
Biogenesis of functional cytochrome c oxidase in yeast requires the product of the nuclear gene SCO1. Strains deleted for this gene fail to accumulate the mitochondrially-synthesized cytochrome c oxidase subunits I and II, despite the presence of the respective mRNAs. Here we present data which demonstrate that the observed phenotype does not result from a failure to translate the mRNAs, but from a preferential degradation of the newly synthesized subunits. The SCO1 protein is therefore involved in a post-translational step in the accumulation of cytochrome c oxidase subunits I and II. We propose that the SCO1 protein is required for the correct assembly of both subunits into the cytochrome c oxidase complex.
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Authors and Affiliations
- Labor für Molekulare Biologie und Allgemeine Pathologie des Instituts für Pathologie der Universität Ulm, Neuherbergstrasse 11, D-8000, München 45, Federal Republic of Germany
G. Krummeck & G. Rödel
Authors
- G. Krummeck
- G. Rödel
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Communicated by R. J. Schweyen
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Krummeck, G., Rödel, G. Yeast SCO1 protein is required for a post-translational step in the accumulation of mitochondrial cytochrome c oxidase subunits I and II.Curr Genet 18, 13–15 (1990). https://doi.org/10.1007/BF00321109
- Received: 05 March 1990
- Issue date: July 1990
- DOI: https://doi.org/10.1007/BF00321109