Lithium effects on active and passive avoidance behavior in the rat (original) (raw)
Abstract
Lithium chloride reduced the rate of acquisition of a passive-avoidance response and decreased the rats' reaction to the shock delivery. Acquisition of an active-avoidance response was unimpaired by lithium, although lithium-administered rats responded predominantly to the cue stimulus, making significantly fewer precue avoidance responses than did controls. Lithium's efficacy in the treatment of manic disorders may, therefore, be the result of a decrease in the individual's reactivity to low-intensity stimulation.
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- Department of Psychology, University of Arkansas at Little Rock, 72204, Little Rock, AR, USA
Garth Hines & Tommy H. Poling
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- Garth Hines
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Hines, G., Poling, T.H. Lithium effects on active and passive avoidance behavior in the rat.Psychopharmacology 82, 78–82 (1983). https://doi.org/10.1007/BF00426385
- Received: 21 September 1982
- Accepted: 30 September 1983
- Issue Date: December 1983
- DOI: https://doi.org/10.1007/BF00426385