Clonidine produces a conditioned place preference in rats (original) (raw)

Abstract

The possibility that the α-adrenergic agonist clonidine can act as a reinforcing agent was investigated using the conditioned place preference paradigm. Using two different variants of this method we were able to demonstrate reinforcing properties of clonidine at doses of 200 and 400 μg/kg. These results are consistent with those obtained by other investigators using the self-administration technique, and support the view that adrenergic mechanisms may be involved in reinforcement.

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Authors and Affiliations

1. Dept. Psychology, University of Illinois-Chicago, P.O. Box 4348, 60680, Chicago, II, USA
   Karen E. Asin & David Wirtshafter

Authors

1. Karen E. Asin
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2. David Wirtshafter
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Asin, K.E., Wirtshafter, D. Clonidine produces a conditioned place preference in rats.Psychopharmacology 85, 383–385 (1985). https://doi.org/10.1007/BF00428206

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• Received: 27 August 1984
• Accepted: 01 November 1984
• Issue Date: March 1985
• DOI: https://doi.org/10.1007/BF00428206

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