Intermediate-sized filament proteins (prekeratin, vimentin, desmin) in the normal parotid gland and parotid gland tumours (original) (raw)

Summary

Antibodies to different intermediate-sized filament proteins can distinguish cells and tissues of epithelial, mesenchymal, muscle, astrocytic and neural origin. Antibodies to prekeratin, vimentin and desmin have been used to distinguish cells of epithelial, mesenchymal and muscle origin in the normal human parotid gland, and in addition to study some common tumors of this gland. Prekeratin-positive and vimentin-positive cells are found among the tumor cells in the pleomorphic adenomas. In contrast the tumor cells of the mucoepidermoid tumors and squamous cell carcinomas are prekeratin-positive but vimentin-negative.

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Authors and Affiliations

1. Institute of Pathology, University of Hamburg, Martinistraße 52, D-2000, Hamburg 20, Federal Republic of Germany
   J. Caselitz & G. Seifert
2. Max Planck Institute for Biophysical Chemistry, D-3400, Göttingen, Federal Republic of Germany
   M. Osborn & K. Weber

Authors

1. J. Caselitz
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2. M. Osborn
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3. G. Seifert
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4. K. Weber
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Supported by the Deutsche Forschungsgemeinschaft (Ca 93/1-1) and by the Hamburger Stiftung zur Förderung der Krebsbekämpfung

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Caselitz, J., Osborn, M., Seifert, G. et al. Intermediate-sized filament proteins (prekeratin, vimentin, desmin) in the normal parotid gland and parotid gland tumours.Virchows Arch. A Path. Anat. and Histol. 393, 273–286 (1981). https://doi.org/10.1007/BF00430827

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• Accepted: 13 July 1981
• Issue Date: November 1981
• DOI: https://doi.org/10.1007/BF00430827

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