Biological properties of VEGF/VPF receptors (original) (raw)
References
Gospodarowicz D, Abraham FA, Schilling J: Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells. Proc Natl Acad Sci USA 86: 7311–7315, 1989 Google Scholar
Shweiki D, Itin A, Soffer D Keshet E: Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359: 843–845, 1992 Google Scholar
Millauer B, Shawver LK, Plate KH, Risau W, Ullrich A: Glioblastoma growth inhibited in vivo by a dominant-negative Flk1 mutant. Nature 367: 576–579, 1994 Google Scholar
Kim J, Li B, Winer J, Armaninum M, Gillet N, Phiips HS, Ferrara N: Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo. Nature 262: 841–844, 1993 Google Scholar
Terman BI, Carrion ME, Kovacs E, Rasmussen R, Eddy RL, Shows TB: Identification of a new endothelial cell growth factor receptor tyrosine kinase. Oncogene 6: 1677–1683, 1991 Google Scholar
Terman BI, Dougher-Vermanzen M, Carrion ME, Dimitrov D, Armellino DC, Gospodarowicz D, Bohlen P: Identification of the KDR tyrosine kinase as a receptor for vascular endothelial growth factor. Biochem Biophys Res Com 187: 1579–1586, 1992 Google Scholar
Mattews W, Jordan CT, Gavin M, Jenkins NA, Copeland NG, Lemischka IR, A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit. Proc Natl Acad Sci USA 88: 9026–9030, 1991 Google Scholar
Millauer B, Wizigmann-Voos S, Schnurch H, Martinez R, Moller NPH, Risau W, Ullrich A: High affinity VEGF binding and developmental expression suggest FLK-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72: 835–846, 1993 Google Scholar
Shibuya M, Yamaguchi S, Yamane A, Ikeda T, Tojo A, Matsushime H, Sato M: Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. Oncogene 5: 519–524, 1990 Google Scholar
De Vries C, Escobedo JA, Ueno H, Houck K, Ferrara N, Williams LT: The _fms_-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255: 989–991, 1992 Google Scholar
Fantl WJ, Johnson DE, Williams LT: Signalling by receptor tyrosine kinases. Ann Rev Biochem 62: 453–481, 1993 Google Scholar
Pajusola K, Aprlikova O, Korhonen J, Kaipainen A, Pertovaara L, Alitalo R, Alitalo K: FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines. Cancer Res 52: 5738–5743, 1992 Google Scholar
Galland F, Karamysheva A, Pebusque M-J, Borg J-P, Rottapel R, Dubreuil P, Rosnet O, Birnbaum D: The FL4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor. Oncogene 8: 1233–1240, 1993 Google Scholar
Keck PJ, Hauser SD, Krivi G, Sanzo K, Warren T, Feder J, Connolly DT: Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246: 1309–1312, 1989 Google Scholar
Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N: Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246: 1306–1309, 1989 Google Scholar
Conn G, Bayne ML, Soderman DD, Kwok PW, Sullivan KA, Palisi TM, Hope DA, Thomas KA: Amino acid and cDNA sequence of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor. Proc Natl Acad Sci USA 87: 2628–2632, 1990 Google Scholar
Maglione D, Guerriero V, Viglietto G, Delli-Bovi P, Persico MG: Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. Proc Natl Acad Sci USA 88: 9267–9271, 1991 Google Scholar
Kendall RL, Wang G, DiSalvo J, Thomas KA: Specificity of vascular endothelial cell growth factor receptor ligand binding domains. Biochem Biophys Res Commun 201: 326–330, 1994 Google Scholar
Park JE, Chen HH, Winer J, Houck KA, Farrara N: Placenta growth factor. J Biol Chem 269: 25646–25654, 1994 Google Scholar
Terman BI, Khandke L, Dougher-Vermazon M, Maglione D, Lassam NJ, Gospodarowicz D, Persico MG, Bohlen P, Eisinger M: VEGF receptor subtypes KDR and FLT1 show different sensitivities to heparin and placenta growth factor. Growth Factors 11: 187–195, 1994 Google Scholar
DiSalvo J, Bayne ML, Conn G, Kwok PW, Trivedi PG, Soderman DD, Palisi TM, Sullivan KA, Thomas KA: Purification and characterization of a naturally occurring vascular growth factor/placenta growth factor heterodimer. J Biol Chem 270: 7717–7723, 1995 Google Scholar
Gitay-Goren H, Soker S, Vlodavsky I, Neufeld: The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules. J Biol Chem 267: 6093–6098, 1992 Google Scholar
Tessler S, Rockwell P, Hicklin D, Cohen T, Levi B-Z, Witte L, Lemischka IR, Neufeld G: Heparin modulates the interaction of VEGF165 with soluble and cell associated _flk_-1 receptors. J Biol Chem 269: 12456–12461, 1994 Google Scholar
Kaplan J, Dougher-Vermazen M, Terman BI: Manuscript in preparation
Ornitz D, Yayon A, Flanagan JG, Svahn CM, Levi E, Leder P: Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells. Mol Cell Biol 12: 240–247, 1992 Google Scholar
Kan M, Wang F, Xu F, Crabb JW, Hou J, Mckeehan WL: An essential heparin-binding domain in the fibroblast growth factor receptor kinase. Science 259: 1918–1921, 1993 Google Scholar
Burgess WH, Maciag T: The heparin-binding (fibroblast) growth factor family of proteins. Ann Rev Biochem 58: 575–606, 1989 Google Scholar
Soker S, Goldstaub D, Svahn CM, Vlodavsky I, Levi B-Z, Neufeld G. Variations in the size of sulfation of heparin modulate the effect of heparin on the binding of VEGF165 to its receptors. Biochem Biophys Res Commun 203: 1339–1347, 1994 Google Scholar
Cohen T, Gitay-Goren H, Sharon R, Shibuya M, Halaban R, Levi B-Z, Neufeld G: VEGF121, a vascular endothelial growth factor (VEGF) isoform lacking heparin binding ability, requires cell-surface heparan sulfates for efficient binding to the VEGF receptors of human melanoma cells. J Biol Chem 270: 11322–11326, 1995 Google Scholar
Klagsbrun M, Baird A: A dual receptor system is required for basic fibroblast growth factor activity. Cell 67: 229–231, 1991 Google Scholar
Tischer E, Mitchell R, Hartman T, Silva M, Gospodarowicz D, Fiddes JC, Abraham JA: The human gene for vascular endothelial growth factor. J Biol Chem 266: 11947–11954, 1991 Google Scholar
Houck KA, Farrara N, Winer J, Cachianes G, Li B, Leung DW: The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol 5: 1806–1814, 1991 Google Scholar
Waltenberger J, Claesson-Welsh L, Siegnahn A, Shibuya S, Heldin C-H: Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J Biol Chem 269: 26988–26995, 1994 Google Scholar
Dougher-Vermazen M, Holmes J, Bohlen P, Terman BI: Biological activity of autophosphorylation sites of the bacterially expressed cytosolic domain of the KDR VEGF receptor. Biochem Biophys Res Commun 205: 728–738, 1994 Google Scholar
Seetharam L, Gotoh N, Maru Y, Neufeld G, Yamaguchi S, Shibuya M: A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF. Oncogene 10: 135–147, 1995 Google Scholar
Cunningham SA, Waxham MN, Arrate PM, Brock TA: Interaction of the FLT-1 tyrosine kinase receptor with the p85 subunit of phosphatidylinositol 3-kinase. J Biol Chem 270: 20254–20257, 1995 Google Scholar
Takahashi Y, Kitadai Y, Bucana CD, Cleary KR, Ellis LM: Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res 55: 3964–3968, 1995 Google Scholar
Wizigmann-Voos S, Breier G, Risau W, Plate KH: Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas. Cancer Res 55: 1358–1364, 1995 Google Scholar
Plate KH, Breier G, Weich HA, Risau W: Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 359: 845–848, 1992 Google Scholar
Warren RS, Yuan H, Matli MR, Gillett NA, Ferrara N: Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis. J Clin Invest 95: 1789–1797, 1995 Google Scholar
Peters KG, De Vries C, Williams LT: Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth. Proc Natl Acad Sci USA 90: 8915–8919, 1993 Google Scholar
Brown LF, Olbricht SM, Berse B, Jackman RW, Matsueda G, Tognazzi KA, Manseau EJ, Dvorak HF, Van De Water L: Overexpression of vascular permeability factor (VPF/VEGF) and its endothelial cell receptors in delayed hypersensitivity skin reactions. J Immunology 22: 2801–2807, 1995 Google Scholar