Craniosynostosis in hyper-IgE-syndrome (original) (raw)

Abstract

A 9-year-old boy with hyperimmunoglobulin-E-syndrome (HIE) and craniosynostosis is reported. Premature fusion of the sagittal and lambdoid suture led to scaphocephaly. A partial optic atrophy without clinical signs of raised intracranial pressure was observed. This is the fourth reported case of craniosynostosis in HIE. Bone anomalies like osteoporosis are frequent findings in HIE. Apart from their clinical impact they could be related to factors involved in the pathogenesis of HIE, such as impairment of chemotaxis in tissues or monocyte differentiation.

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Abbreviations

HIE:

hyperimmunoglobulin-E-syndrome

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Author notes

  1. P. H. Höger
    Present address: Universitäts-Kinderklinik, Josef-Schneider-Str. 2, D-8700, Würzburg, Federal Republic of Germany

Authors and Affiliations

  1. Department of Pediatrics, Divisions of Immunology/Hematology and Neuropediatrics, University of Zürich, Zürich, Switzerland
    P. H. Höger, E. Boltshauser & W. H. Hitzig

Authors

  1. P. H. Höger
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  2. E. Boltshauser
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  3. W. H. Hitzig
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Höger, P.H., Boltshauser, E. & Hitzig, W.H. Craniosynostosis in hyper-IgE-syndrome.Eur J Pediatr 144, 414–417 (1985). https://doi.org/10.1007/BF00441793

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