Transport defects as the physiological basis for eye color mutants of Drosophila melanogaster (original) (raw)
Abstract
Kynurenine-H_3_ transport and conversion to 3-hydroxykynurenine were studied in organ culture using the Malpighian tubules and developing eyes from wild type and the eye color mutants w, st, 1td, ca, and cn of Drosophila melanogaster. Malpighian tubules from wild type have the ability to concentrate kynurenine and convert it to 3-hydroxykynurenine. The tubules from w, st, 1td, and ca are deficient in the ability to transport kynurenine, as are the eyes of the mutants w, st, and 1td. This defect in kynurenine transport provides a physiological explanation for the phenotypic properties of the mutants. The relationship of these measurements to previous observations on these eye color mutants is discussed and the transport defect hypothesis is consistently supported. We have concluded that several of the eye color mutants in Drosophila are transport mutants.
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Authors and Affiliations
- Department of Biology, Syracuse University, Syracuse, New York
David T. Sullivan & Marie C. Sullivan
Authors
- David T. Sullivan
- Marie C. Sullivan
Additional information
Supported by Grant GB-38645 from N.S.F. and Grant GM-21286-01 from N.I.H.
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Sullivan, D.T., Sullivan, M.C. Transport defects as the physiological basis for eye color mutants of Drosophila melanogaster.Biochem Genet 13, 603–613 (1975). https://doi.org/10.1007/BF00484918
- Received: 15 November 1974
- Revised: 24 March 1975
- Issue date: October 1975
- DOI: https://doi.org/10.1007/BF00484918