Altered frequency of initiation sites of DNA replication in Werner's syndrome cells (original) (raw)

Summary

DNA replication of cultured fibroblasts of early passage derived from Werner's syndrome (adult progeria) patients and from normal subjects were compared by DNA fiber autoradiography. The frequency of replication initiation was decreased in Werner's syndrome cells derived from five patients compared with that in normal cells derived from three persons of different ages. The rate of DNA chain elongation did not differ between Werner's syndrome cells and normal cells.

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Authors and Affiliations

1. Department of Internal Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, 113, Hongo, Tokyo, Japan
   Fujio Takeuchi, Makoto Goto & Terumasa Miyamoto
2. Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, University of Tokyo, 113, Hongo, Tokyo, Japan
   Fumio Hanaoka & Masa-atsu Yamada
3. 2nd Department of Internal Medicine, Faculty of Medicine, University of Teikyo, 173, Itabashi, Tokyo, Japan
   Ieo Akaoka
4. Division of Genetics, National Institute of Radiological Sciences, Anagawa, 260, Chiba, Japan
   Tada-aki Hori

Authors

1. Fujio Takeuchi
2. Fumio Hanaoka
3. Makoto Goto
4. Ieo Akaoka
5. Tada-aki Hori
6. Masa-atsu Yamada
7. Terumasa Miyamoto

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Takeuchi, F., Hanaoka, F., Goto, M. et al. Altered frequency of initiation sites of DNA replication in Werner's syndrome cells.Hum Genet 60, 365–368 (1982). https://doi.org/10.1007/BF00569220

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• Received: 05 January 1982
• Issue date: December 1982
• DOI: https://doi.org/10.1007/BF00569220

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