Interaction between accumbens D1 and D2 receptors regulating rat locomotor activity (original) (raw)

Abstract

The effect of intra-accumbens injections of various dopaminergic agonists and antagonists on the rat locomotor activity has been evaluated in automated open fields. Locomotor stimulation has been observed after local administration of_d_-amphetamine (10 μg), apomorphine (10 μg), as well as of solution containing the D1 agonist SKF 38 393 and D2 receptor agonist LY 171 555 (quinpirole) in doses (10 and 4 μg, respectively) which were inactive when both drugs were administered separately. On the other hand separate injections of metoclopramide (0.1 μg) and SCH 23 390 (0.5 μg) (D2 and D1 receptor antagonists) very potently inhibited animals' locomotor activity. The data indicate that concomitant stimulation of both accumbens D1- and D2-receptor related mechanisms is a necessary condition to increase rat motility. Moreover, it seems that accumbens D1 receptors may be differently involved in the control of facilitatory versus inhibitory motor processes.

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Authors and Affiliations

1. Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Al. Sobieskiego 1/9, PL-02-953, Warsaw, Poland
   Adam Plaznik, Roman Stefanski & Wojciech Kostowski

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1. Adam Plaznik
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2. Roman Stefanski
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3. Wojciech Kostowski
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Plaznik, A., Stefanski, R. & Kostowski, W. Interaction between accumbens D1 and D2 receptors regulating rat locomotor activity.Psychopharmacology 99, 558–562 (1989). https://doi.org/10.1007/BF00589908

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• Received: 05 January 1989
• Accepted: 25 May 1989
• Issue Date: December 1989
• DOI: https://doi.org/10.1007/BF00589908

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