Cimetidine interaction with amitriptyline (original) (raw)
Summary
The interaction of cimetidine with amitriptyline was assessed by means of amitriptyline and nortriptyline plasma concentration measurements, standing blood pressure and pulse rate, digit symbol substitution, and visual analogue scales. Cimetidine increased plasma amitriptyline concentrations and decreased plasma nortriptyline concentrations, apparently by inhibiting presystemic metabolism. The changes in blood pressure, pulse rate and digit symbol substitution correlated with changes in concentrations of amitriptyline in plasma and expected changes based on a dose ranging preliminary experiment. Changes in subjective ratings of effects correlated with changes in nortriptyline concentrations in plasma.
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Authors and Affiliations
- Colleges of Pharmacy and Medicine, University of Florida, 32610, Gainesville, Florida, USA
S. H. Curry, C. L. DeVane & M. M. Wolfe
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- S. H. Curry
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Curry, S.H., DeVane, C.L. & Wolfe, M.M. Cimetidine interaction with amitriptyline.Eur J Clin Pharmacol 29, 429–433 (1985). https://doi.org/10.1007/BF00613457
- Received: 09 April 1985
- Accepted: 27 August 1985
- Issue Date: July 1985
- DOI: https://doi.org/10.1007/BF00613457