Keshan disease-an endemic cardiomyopathy in China (original) (raw)

Summary

Keshan disease, an endemic cardiomyopathy in China, was prevalent in rural areas located in a long belt region where the selenium content was low in foods. Intervention studies with well controled subjects revealed a prophylactic effect of sodium selenite. Multifocal necrosis and fibrous replacement of the myocardium characterized the histopathological features and myocytolysis was present in most cases. Ultrastructural observations on twelve postmortem cases revealed remarkable changes in many organelles of which mitochondria appeared to be most important in the development of myocardial lesions. Three kinds of specific granules, which have not been found in other reports on cardiomyopathies, were represented and other factors which might also contribute to the aetiology are discussed.

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Keshan Disease

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Authors and Affiliations

1. Institute of Health, Chinese Academy of Medical Sciences, 29 Nan Wei Road, Beijing, The People's Republic of China
   Keyou Ge, Anna Xue, Jin Bai & Shuqin Wang

Authors

1. Keyou Ge
2. Anna Xue
3. Jin Bai
4. Shuqin Wang

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Ge, K., Xue, A., Bai, J. et al. Keshan disease-an endemic cardiomyopathy in China.Vichows Archiv A Pathol Anat 401, 1–15 (1983). https://doi.org/10.1007/BF00644785

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• Accepted: 19 April 1983
• Issue date: January 1983
• DOI: https://doi.org/10.1007/BF00644785

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