Fludarabine- and gemcitabine-induced apoptosis: incorporation of analogs into DNA is a critical event (original) (raw)
References
Arends MJ, Morris RG, Wyllie AH (1990) Apoptosis, the role of the endonuclease. Am J Pathol 136:593 Google Scholar
Barry MA, Behnke CA, Eastman A (1990) Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia. Biochem Pharmacol 40:2353 Google Scholar
Cohen JJ, Duke RC (1984) Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J Immunol 132:38 Google Scholar
Evans DL, Dive C (1993) Effects of cisplatin on the induction of apoptosis in proliferating hepatoma cells and nonproliferating immature thymocytes. Cancer Res 53:2133 Google Scholar
Fairbairn LJ, Cowling GJ, Reipert BM, Dexter TM (1993) Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors. Cell 74:823 Google Scholar
Fesus L, Davis PJA, Piacentini M (1991) Apoptosis: molecular mechanisms in programmed cell death. Eur J Cell Biol 56:170 Google Scholar
Gandhi V, Plunkett W (1988) Modulation of arabinosylnucleoside metabolism by arabinosylnucleotides in human leukemia cells. Cancer Res 48:329 Google Scholar
Gorczyca W, Gong J, Ardelt B, Traganos F, Darzynkiewicz Z (1993) The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents. Cancer Res 53:3186 Google Scholar
Gunji H, Kharbanda S, Kufe D (1991) Induction of internucleosomal DNA fragmentation in human myeloid leukemia cells by 1-β-d-arabinofuranosylcytosine. Cancer Res 51:741 Google Scholar
Heinemann V, Xu Y-Z, Chubb S, Sen A, Hertel LW, Grindey GB, Plunkett W (1990) Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2′,2′-difluorodeoxycytidine. Mol Pharmacol 38:567 Google Scholar
Huang P, Plunkett W (1992) A quantitative assay for fragmented DNA in apoptotic cells. Anal Biochem 207:163 Google Scholar
Huang P, Plunkett W (1993) Replicon-sized DNA fragmentation induced by nucleoside analogs. Proc Am Assoc Cancer Res 34:289 Google Scholar
Huang P, Plunkett W (1994) Drug-induced apoptosis: relationship between DNA fragmentation and cell death. Proc Am Assoc Cancer Res 35:313 Google Scholar
Huang H, Siciliano MJ, Plunkett W (1989) Gene deletion, a mechanism of induced mutation by arabinosyl nucleosides. Mutat Res 210:291 Google Scholar
Huang P, Chubb S, Plunkett W (1990) Termination of DNA synthesis by 9-β-d-arabinofuranosyl-2-fluoroadenine, a mechanism for cytotoxicity. J Biol Chem 265:16617 Google Scholar
Huang P, Chubb S, Hertel LW, Grindey GB, Plunkett W (1991) Action of 2′,2′-difluorodeoxycytidine on DNA synthesis. Cancer Res 51:6110 Google Scholar
Itoh N, Yonehara S, Ishii A, Yonehara M, Mizushima S-I, Sameshima M, Hase A, Seto Y, Nagata S (1991) The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66:233 Google Scholar
Kamiya K, Huang P, Plunkett W (1993) Excision of incorporated fludarabine from DNA by human DNA polymerase ɛ. Proc Am Assoc Cancer Res 34:349 Google Scholar
Kaufmann SH (1989) Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. Cancer Res 49:5870 Google Scholar
Kaufmann SH, Karp JE, Jones RJ, Miler KB, Schneider E, Zwelling LA, Cowan K, Wendel K, Burke PJ (1994) Topoisomerase II levels and drug sensitivity in adult acute myelogenous leukemia. Blood 83:517 Google Scholar
Major PP, Egan EM, Beardsley GP, Minden MD, Kufe DW (1981) Lethality of human myeloblasts correlates with the incorporation of arabinofuranosylcytosine into DNA. Proc Natl Acad Sci USA 78:3235 Google Scholar
Matherly LH, Schuetz JD, Westin E, Goldman ID (1989) A method for the synchronization of cultured cells with aphidicolin: application to the large-scale synchronization of L1210 cells and the study of the cell cycle regulation of thymidylate synthase and dihydrofolate reductase. Anal Biochem 182:338 Google Scholar
McConkey DJ, Hartzell P, Duddy SK, Hakansson H, Orrenius S (1988) 2,3,7,8-Tetrachlorodibenzo-_p_-dioxin kills immature thymocytes by Ca2+-mediated endonuclease activation. Science 242:256 Google Scholar
Michaelson J (1991) The significance of cell death. In: Tomei LD, Cope FO (eds) Apoptosis, the molecular basis of cell death. Cold Spring Harbor Laboratory Press, New York, p 31 Google Scholar
Oberhammer F, Wilson JW, Dive C, Morris ID, Hickman JA, Wakeling AE, Walker PR, Sikorska M (1993) Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO J 12:3679 Google Scholar
Parker WB, Bapat AR, Shen J-X, Townsend AJ, Cheng C-Y (1988) Interaction of 2-halogenated dATP analogs (F, Cl, and Br) with human DNA polymerases, DNA primase, and ribonucleotide reductase. Mol Pharmacol 34:485 Google Scholar
Robertson LE, Chubb S, Meyn RE, Story M, Ford R, Hittelman WN, Plunkett W (1993) Induction of apoptotic cell death in chronic lymphocytic leukemia by 2-chloro-2′-deoxyadenosine and 9-β-d-arabinosyl-2-fluoroadenine. Blood 81:143 Google Scholar
Sandoval A, Plunkett W (1994) Inhibition of UV-induced DNA repair in quiescent human peripheral blood lymphocytes by fludarabine stimulates apoptosis. Proc Am Assoc Cancer Res 35:395 Google Scholar
Sassanfar M, Roberts JW (1990) Nature of the SOS-inducing signal in Escherichia coli, the involvement of DNA replication. J Mol Biol 212:79 Google Scholar
Sellins KS, Cohen JJ (1987) Gene induction by γ-irradiation leads to DNA fragmentation in lymphocytes. J Immunol 139:3199 Google Scholar
Tartaglia LA, Ayres TM, Wong GH, Goeddel DV (1993) A novel domain within the 55 kd TNF receptor signals cell death. Cell 74:845 Google Scholar
Thompson HJ, Strange R, Schedin PJ (1992) Apoptosis in the genesis and prevention of cancer. Cancer Epidemiol Biomarkers Prev 1:597 Google Scholar
Trauth BC, Klas C, Peters AMJ, Matzku S, Moller P, Falk W, Debatin K-M, Krammer PH (1989) Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 245:301 Google Scholar
Walker GC (1984) Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. Microbiol Rev 48:60 Google Scholar
Walker PR, Smith C, Youdale T, Leblanc J, Whitfield JF, Sikorska M (1991) Topoisomerase II-reactive chemotherapeutic drugs induce apoptosis in thymocytes. Cancer Res 51:1078 Google Scholar
Walker PR, Kokileva L, LeBlanc J, Sikorska M (1993) Detection of the initial stages of DNA fragmentation in apoptosis. Biotechniques 15:1032 Google Scholar
Wang Z, Wu X, Friedberg EC (1993) Nucleotide-excision repair of DNA in cell-free extracts of the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci USA 90:4907 Google Scholar
Warters RL (1990) Radiation-induced apoptosis in a murine T-cell hybridoma. Cancer Res 52:883 Google Scholar
Williams GT, Smith CA, Spooncer E, Dexter TM, Taylor TR (1990) Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis. Nature 343:76 Google Scholar
Wyllie AH, Kerr JFR, Currir AR (1980) Cell death: the significance of apoptosis. Int Rev Cytol 68:251 Google Scholar
Yang SW, Huang P, Plunkett W, Becker FF, Chan JYH (1992) Dual mode of inhibition of purified DNA ligase I from human cells by 9-β-D-arabinofuranosyl-2-fluoroadenine triphosphate. J Biol Chem 267:2345 Google Scholar