Eccrine sweat glands are not innervated in hereditary sensory neuropathy type IV (original) (raw)

Summary

The ultrastructural study of a skin biopsy in a patient afflicted with hereditary sensory neuropathy type IV (congenital insensitivity to pain with anhidrosis) did not reveal any unmyelinated axons or axonal terminals around eccrine sweat glands but only proccsses, partially covered by a basement membrane and therefore resembling Schwann cell processes. The absence of such unmyelinated axons in close proximity to eccrine sweat glands where they normally occur appears to be the morphological equivalent to the anhidrosis and also corresponds to the deficiency of unmyelinated axons in the sural nerve of the same patient, as previously reported.

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Authors and Affiliations

1. Division of Neuropathology, University of Göttingen, Robert-Koch-Str. 40, D-3400, Göttingen, Germany
   J. Langer & H. H. Goebel
2. Department of Pediatrics, Medical School of Hannover, D-3000, Hannover, Germany
   S. Veit

Authors

1. J. Langer
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2. H. H. Goebel
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3. S. Veit
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Supported by the Deutsche Forschungsgemeinschaft, grant no. Go 185/3

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Langer, J., Goebel, H.H. & Veit, S. Eccrine sweat glands are not innervated in hereditary sensory neuropathy type IV.Acta Neuropathol 54, 199–202 (1981). https://doi.org/10.1007/BF00687742

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• Received: 16 February 1981
• Accepted: 13 March 1981
• Issue Date: September 1981
• DOI: https://doi.org/10.1007/BF00687742

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