Antigen-induced protection against infection withToxocara vitulorum larvae in mice (original) (raw)
Abstract
Larvae of_Toxocara vitulorum_ hatched and migrated in the tissues of normal mice. Larvae survived in reasonable numbers, particularly in the liver and, to a lesser extent, in the lungs and kidneys, for at least 4–7 days and in muscles, albeit only in low numbers, for at least 3 weeks. Oral infection of mice on three or more occasions with_T. vitulorum_ eggs induced protection against a challenge infection with eggs of_T. vitulorum_. Prior parenteral immunization of mice with a variety of_T. vitulorum_ soluble antigens (extracts, excretions/secretions, or perienteric fluid and their fractions) from adult parasites and/or infective larvae induced statistically significant protection against infection. The most effective protective immunogens were three or more injections with perienteric fluid from adults (100% protection) and excretions/secretions from infective larvae of_T. vitulorum_ (>92% protection).
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Authors and Affiliations
- Faculties of Veterinary Medicine and Animal Science and Zoology, University of Peradeniya, Peradeniya, Sri Lanka
P. H. Amerasinghe, R. P. V. J. Rajapakse & S. T. Fernando - Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Rd., CB3 OES, Cambridge, UK
S. Lloyd
Authors
- P. H. Amerasinghe
- R. P. V. J. Rajapakse
- S. Lloyd
- S. T. Fernando
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Amerasinghe, P.H., Rajapakse, R.P.V.J., Lloyd, S. et al. Antigen-induced protection against infection with_Toxocara vitulorum_ larvae in mice.Parasitol Res 78, 643–647 (1992). https://doi.org/10.1007/BF00931514
- Accepted: 01 September 1992
- Issue date: August 1992
- DOI: https://doi.org/10.1007/BF00931514