Prognostic implications of chromosome 17p deletions in human medulloblastomas (original) (raw)

Abstract

DNA derived from medulloblastoma biopsies was analyzed to determine if deletions of the 17p region, mutations of the_TP53_ gene, or amplification of the c-myc, N-myc, EGFR (epidermal growth factor receptor), or_MDM2_ (murine double-minute-2) genes was indicative of a poor prognosis. Loss of heterozygosity for 17p, observed in 8/28 (29%) paired samples, was associated with a shortened survival period (p=0.045 by the logrank test).TP53 mutations occurred in 2/46 (4.3%) tumor samples. c-myc Amplification was seen in 3/43 (6.9%) cases, while none of the tumors contained amplified N-myc, EGFR, or_MDM2_ genes. These results demonstrate that, while only rare medulloblastomas contain_TP53_ gene mutations or amplification of the c-myc gene, loss of heterozygosity on chromosome 17p is indicative of a significantly worse prognosis among patients with these tumors. Further, these results provide a strong impetus for a prospective analysis of loss of heterozygosity in a cooperative group setting, which would include tumor staging, a selection of treatment modalities, and multivariate analyses.

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Authors and Affiliations

  1. Department of Pathology, Duke University Medical Center, Durham, North Carolina
    Surinder K. Batra, Roger E. McLendon, Ja Seok Koo, Shobha Castelino-Prabhu, Henry S. Friedman, Darell D. Bigner & Sandra H. Bigner
  2. Department of Surgery (Neurosurgery), Duke University Medical Center, Durham, North Carolina
    Herbert E. Fuchs
  3. Department of Pediatrics, Duke University Medical Center, Durham, North Carolina
    Henry S. Friedman
  4. Department of Preuss Laboratory for Brain Tumor Research, Duke University Medical Center, Durham, North Carolina
    Henry S. Friedman & Darell D. Bigner
  5. H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida, USA
    Jeffrey P. Krischer

Authors

  1. Surinder K. Batra
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  2. Roger E. McLendon
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  3. Ja Seok Koo
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  4. Shobha Castelino-Prabhu
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  5. Herbert E. Fuchs
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  6. Jeffrey P. Krischer
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  7. Henry S. Friedman
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  8. Darell D. Bigner
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  9. Sandra H. Bigner
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Batra, S.K., McLendon, R.E., Koo, J.S. et al. Prognostic implications of chromosome 17p deletions in human medulloblastomas.J Neuro-Oncol 24, 39–45 (1995). https://doi.org/10.1007/BF01052657

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