Influence of food and diet on gastrointestinal drug absorption: A review (original) (raw)
T. R. Bates and M. Gibaldi. Gastrointestinal absorption of drugs. In J. Swarbrick (ed.),Current Concepts in the Pharmaceutical Sciences: Biopharmaceutics, Lea and Febiger, Philadelphia, 1970, pp. 57–99. Google Scholar
M. Rowland. Effect of some physiological factors on bioavailability of oral dosage forms. In J. Swarbrick (ed.),Current Concepts in the Pharmaceutical Sciences: Dosage Form Design and Bioavailability, Lea and Febiger, Philadelphia, 1973, pp. 181–222. Google Scholar
J. L. Brandt, L. Castleman, H. D. Ruskin, J. Greenwald, J. J. Kelly, and A. Jones. The effect of oral protein and glucose feeding on splanchnic blood flow and oxygen utilization in normal and cirrhotic subjects.J. Clin. Invest.34:1017–1025 (1955). ArticleCASPubMed CentralPubMed Google Scholar
D. I. Abramson and S. M. Fierst, Peripheral vascular responses in man during digestion.Am. J. Physiol.133:686–693 (1941). Google Scholar
E. J. Reininger and L. A. Sapirstein. Effect of digestion on distribution of blood flow in the rat.Science126:1176 (1957). ArticleCASPubMed Google Scholar
M. Gibaldi, R. N. Boyes, and S. Feldman. Influence of first-pass effect on availability of drugs on oral administration.J. Pharm. Sci.60:1338–1340 (1971). ArticleCASPubMed Google Scholar
M. Rowland. Influence of route of administration on drug bioavailability.J. Pharm. Sci.61:70–74 (1972). ArticleCASPubMed Google Scholar
T. J. DeMarco and R. R. Levine. The role of the lymphatics in the intestinal absorption and distribution of drugs.J. Pharmacol. Exp. Ther.169:142–151 (1969). CAS Google Scholar
J. N. Hunt and M. T. Knox. Regulation of gastric emptying. In C. F. Code (ed.),Handbook of Physiology, Sect. 6, Vol. 4:Alimentary Canal, American Physiological Society, Washington, D.C., 1968, pp. 1917–1935. Google Scholar
J. N. Hunt. Gastric emptying and secretion in man.Physiol. Rev.39:491–533 (1959). CASPubMed Google Scholar
A. Hopkins. The pattern of gastric emptying: A new review of old results.J. Physiol. (Land.)182:144–149 (1966). ArticleCAS Google Scholar
J. N. Hunt and I. MacDonald. The influence of volume on gastric emptying.J. Physiol. (Land.)126:459–474 (1954). ArticleCAS Google Scholar
H. W. Davenport.Physiology of the Digestive Tract, Chicago Year Book Publishers, Chicago, 1961, pp. 50, 149. Google Scholar
G. Levy and W. Jusko. Effect of viscosity on drug absorption.J. Pharm. Sci.54:219–225 (1965). ArticleCASPubMed Google Scholar
W. H. Bachrach. Physiology and pathologic physiology of the stomach.Ciba Found. Symp.11:3–28 (1959). CAS Google Scholar
C. S. Marcus and F. W. Lengemann. Absorption of45Ca and85Sr from solid and liquid food at various levels of the alimentary tract of the rat.J. Nutr.77:155–160 (1962). CASPubMed Google Scholar
M. Gibaldi and S. Feldman. Mechanisms of surfactant effects on drug absorption.J. Pharm. Sci.59:579–589 (1970). ArticleCASPubMed Google Scholar
E. H. Dearborn, J. T. Litchfield, Jr., H. J. Eisner, J. J. Corbett, and C. W. Dunnett. The effects of various substances on the absorption of tetracycline in rats.Antibiot. Med.4:627–641 (1957). CASPubMed Google Scholar
K. W. Kohn. Mediation of divalent metal ions in the binding of tetracycline to macromolecules.Nature191:1156–1158 (1961). ArticleCASPubMed Google Scholar
E. Fingl and D. M. Woodbury. In L. S. Goodman and A. Gilman (eds.),The Pharmacological Basis of Therapeutics, Macmillan, New York, 1970, p. 5. Google Scholar
H. C. Ferguson. Dilution of dose and oral toxicity.Toxicol. Appl. Pharmacol.4:759–762 (1962). ArticleCASPubMed Google Scholar
J. L. Borowitz, P. F. Moore, G. K. W. Yim, and T. S. Miya. Mechanism of enhanced drug effects produced by dilution of the oral dose.Toxicol. Appl. Pharmacol.19:164–168 (1971). ArticleCASPubMed Google Scholar
B. K. Martin. The formulation of aspirin. In H. S. Bean, A. H. Beckett, and J. E. Carless (eds.),Advances in Pharmaceutical Sciences, Vol. 3, Academic Press, New York, 1971, pp. 107–171. Google Scholar
H. Ochsenfahrt and D. Winne. The contribution of solvent drag to the intestinal absorption of the acidic drugs benzoic acid and salicylic acid from the jejunum of the rat.Naunyn-Schmiedeberg's Arch. Pharmacol.281:197–217 (1974). ArticleCAS Google Scholar
C. G. McCarthy and M. Finland. Absorption and excretion of four penicillins; penicillin G, penicillin V, phenethicillin and Phenymercaptomethyl penicillin.New Engl. J. Med.263:315–326 (1960). Article Google Scholar
G. A. Cronk, W. B. Wheatley, G. F. Fellers, and H. Albright. The relationship of food intake to the absorption of potassium alpha-phenoxyethyl penicillin and potassium phenoxymethyl penicillin from the gastrointestinal tract.Am. J. Med. Sci.240:219–225 (1960). ArticleCASPubMed Google Scholar
G. A. Cronk, D. E. Naumann, H. Albright, and W. B. Wheatley. Laboratory and clinical studies with potassium penicillin-152 (potassium (_α_-phenoxyethyl)-penicillin).Antibiotics Annual, 1959–1960, Med. Encycl. Inc., 1960, pp. 133–145.
H. Berlin and G. Brante, Studies on oral utilization of penicillin V.Antibiotics Annual, 1958–1959. Med. Encycl. Inc., 1959, pp. 149–157.
F. B. Peck, Jr., and R. S. Griffith. Comparative clinical laboratory studies of potassium penicillin V with acid penicillin V.Antibiotics Annual, 1957–1958, Med. Encycl. Inc., 1958, pp. 1004–1014.
C.-C. Lee, R. O. Froman, R. C. Anderson, and K. K. Chen. Gastric and intestinal absorption of potassium penicillin V and the free acid.Antibiot. Chemother.8:354–360 (1958). CAS Google Scholar
R. C. Gordon, C. Regamy, and W. M. M. Kirby. Comparative clinical pharmacology of amoxicillin and ampicillin administered orally.Antimicrob. Agents Chemother.1:504–507 (1972). ArticleCASPubMed CentralPubMed Google Scholar
H. C. Neu. Antimicrobial activity and human pharmacology of amoxicillin.J. Infect. Dis. (Suppl.)129:S123–8131 (1974). Article Google Scholar
P. G. Welling, H. Huang, P. A. Koch, W. A. Craig, and P. O. Madsen. Bioavailability of ampicillin and amoxicillin in fasted and nonfasted subjects.J. Pharm. Sci.66:549–552 (1977). ArticleCASPubMed Google Scholar
T. G. Vitti, M. J. Gurwith, and A. R. Ronald. Pharmacologic studies of amoxicillin in nonfasting adults.J. Infect. Dis. (Suppl.)129:S149-S153 (1974). Article Google Scholar
W. von Daehne, W. O. Godtfredsen, K. Roholt, and L. Tybring. Pivampicillin a new orally active ampicillin ester.Antimicrob. Agents Chemother.1970:431–437 (1971). Google Scholar
E. L. Foltz, J. W. West, I. H. Breslow, and H. Wallick. Clinical pharmacology of pivampicillin.Antimicrob. Agents Chemother.1970:442–453 (1971). Google Scholar
T. Bergan. Pivampicillin (Pondocillin) a new alternative to ampicillin.Tidsskr. Nor. Laegeforen.92:503–504 (1972). Google Scholar
L. Magni and J. Sjovall. Absorption of ampicillin and pivampicillin in relation to food intake.Farmaceutisk Tidende32:645–648 (1972). Google Scholar
C. A. Fernandez, J. P. Menezes, and J. Ximenes. The effect of food on the absorption of pivampicillin and a comparison with the absorption of ampicillin potassium.J. Int. Med. Res.1:530–533 (1973). CAS Google Scholar
P. J. Neuvonen, G. Gothini, R. Hackman, and K. Björksten. Interference of iron with the absorption of tetracyclines in man.Br. Med. J.4:532–534 (1970). ArticleCASPubMed CentralPubMed Google Scholar
P. G. Neuvonen and H. Turakka. Inhibitory effect of various iron salts on the absorption of tetracycline in man.Eur. J. Clin. Pharmacol.7:357–360 (1974). ArticleCASPubMed Google Scholar
G. E. Schumacher. Drug diffusion and bioavailability: Tetracycline metallic chelation.Am. J. Hosp. Pharm.32:625–629 (1975). Google Scholar
K. W. Price, Z. Zolli, Jr., J. C. Atkinson, and H. G. Luther. Antibiotic inhibitors. II. Studies on the inhibitory action of selected divalent cations for oxytetracycline.Antibiot. Chemother.1:689–701 (1957). Google Scholar
M. P. Braybrooks, B. W. Barry, and E. T. Abbs. The effect of mucin on the bioavailability of tetracycline from the gastrointestinal tract;in vivo-in vitro correlations.J. Pharm. Pharmacol.27:504–515 (1975). Article Google Scholar
P. Neuvonen, M. Mattila, G. Gothini, and R. Hackman. Interference of iron and milk with absorption of tetracycline.Scand. J. Clin. Lab. Invest. (Suppl.)27:76 (1971). Google Scholar
J. Schreiner and W. A. Altemeier. Experimental study of factors inhibiting absorption and effective therapeutic levels of declomycin.Surg. Gynecol. Obstet.114:9–14 (1962). Google Scholar
M. Schach von Wittenau. Some pharmacokinetic aspects of doxycycline metabolism in man.Chemotherapy (Suppl.)13:41–51 (1968). Google Scholar
J. E. Rosenblatt, J. E. Barrett, J. L. Brodie, and W. M. M. Kirby. Comparison of_in vitro_ activity and clinical pharmacology of doxycycline with other tetracyclines.Antimicrob. Agents Chemother.1966:134–141 (1967). Google Scholar
W. M. M. Kirby, C. E. Roberts, and R. E. Burdick. Comparison of two new tetracyclines with tetracycline and demethylchlortetracycline.Antimicrob. Agents Chemother.1961:286–292 (1962). CAS Google Scholar
P. G. Welling, P. A. Koch, C. C. Lau, and W. A. Craig. Bioavailability of tetracycline and doxycycline in fasted and nonfasted subjects.Antimicrob. Agents Chemother.11:462–469 (1977). ArticleCASPubMed CentralPubMed Google Scholar
A. S. D. Spiers and H. R. Malone. Effect of food on aspirin absorption.Lancet1:440 (1967). Article Google Scholar
J. H. Wood. Effect of food on aspirin absorption.Lancet2:212 (1967). Article Google Scholar
M. Rowland, S. Riegelman, P. A. Harris, and S. D. Sholkoff. Absorption kinetics of aspirin in man following oral administration of an aqueous solution.J. Pharm. Sci.61:379–385 (1972). ArticleCASPubMed Google Scholar
M. Gibaldi and B. Grundhofer. Biopharmaceutic influences on the anticholinergic effects of propantheline.Clin. Pharmacol. Ther.18:457–461 (1975). CASPubMed Google Scholar
A. K. Granerus, R. Jagenburg, S. Rödjer, and A. Svanborg. Phenylalanine absorption and metabolism in parkinsonian patients.Br. Med. J.4:262–264 (1971). ArticleCASPubMed CentralPubMed Google Scholar
J. J. Richter and A. Wainer. Evidence for separate systems for the transport of neutral and basic amino acids across the blood-brain barrier.J. Neurochem.18:613–620 (1971). ArticleCASPubMed Google Scholar
N. G. Gillespie, I. Mena, G. C. Cotzias, and M. A. Bell. Diets affecting treatment of parkinsonism with levodopa.J. Am. Diet Assoc.62:525–528 (1973). CASPubMed Google Scholar
S. Furesz, R. Scotti, R. Pallanzer, and E. Mapelli. Rifampicin: A new rifamycin.Arzneim. Forsch.17:534–537 (1967). CAS Google Scholar
L. Verbist and A. Gyselen. Antituberculous activity of rifampin_in vitro_ and_in vivo_ and the concentrations attained in human blood.Am. Rev. Resp. Dis.98:923–932 (1968). CASPubMed Google Scholar
P. E. Dans, R. F. McGehee, C. Wilcox, and M. Finland. Rifampin: Antibacterial activity_in vitro_ and absorption and excretion in normal young men.Amer. J. Med. Sci.259:120–132 (1970). ArticleCASPubMed Google Scholar
K. L. Radenbach. Results of clinical studies with capreomycin, ethambutol and rifampicin in the Heckeshorn Hospital Berlin.Scand. J. Resp. Dis.69:43–54 (1969). CAS Google Scholar
D. I. Siegler, M. Bryant, D. M. Burley, K. M. Citron, and S. M. Standen. Effect of meals on rifampicin absorption.Lancet2:197–198 (1974). ArticleCASPubMed Google Scholar
C. Harvengt, P. de Schepper, F. Lamy, and J. Hansen. Cephradine absorption and excretion in fasting and nonfasting volunteers.J. Clin. Pharmacol.13:36–40 (1973). CAS Google Scholar
T. W. Mischler, A. A. Sugerman, D. A. Willard, L. J. Brannick, and E. S. Neiss. Influence of probenecid and food on the bioavailability of cephradine in normal male subjects.J. Clin. Pharmacol.14:604–611 (1974). ArticleCASPubMed Google Scholar
O. L. Peterson, M. Finland, and A. N. Ballou. The effect of food and alkali on the absorption and excretion of sulfonamide drugs after oral and duodenal administration.Am. J. Med. Sci.204:581–588 (1942). ArticleCAS Google Scholar
H. MacDonald, V. A. Place, H. Falk, and M. A. Darken. Effect of food on absorption of sulfonamides in man.Chemotherapia12:282–285 (1967). ArticleCAS Google Scholar
J. N. Hunt. Gastric emptying in relation to drug absorption.Am. J. Digest. Dis.8:885–894 (1963). ArticleCASPubMed Google Scholar
J. J. Jaffe, J. L. Colaizzi, and H. Barry. Effects of dietary components on GI absorption of acetaminophen tablets in man.J. Pharm. Sci.60:1646–1650 (1971). ArticleCASPubMed Google Scholar
N. Sanchez, L. B. Sheiner, H. Halkin, and K. L. Melmon. Pharmacokinetics of digoxin: Interpreting bioavailability.Br. Med. J.4:132–134 (1973). ArticleCASPubMed CentralPubMed Google Scholar
D. J. Greenblatt, D. W. Duhme, J. Koch-Weser, and T. W. Smith. Bioavailability of digoxin tablets and elixir in the fasting and postprandial states.Clin. Pharmacol. Ther.16:444–448 (1974). CASPubMed Google Scholar
R. J. White, D. A. Chamberlain, M. Howard, and T. W. Smith. Plasma concentrations of digoxin after oral administration in the fasting and postprandial state.Br. Med. J.1:380–381 (1971). ArticleCASPubMed CentralPubMed Google Scholar
M. R. Kelly, R. E. Cutler, A. W. Forrey, and B. M. Kimpel. Pharmacokinetics of orally administered furosemide.Clin. Pharmacol. Ther.15:178–186 (1974). CASPubMed Google Scholar
D. Ben-Ishay and K. Engelman. Bioavailability of potassium from a slow-release tablet.Clin. Pharmacol. Ther.14:250–258 (1973). CASPubMed Google Scholar
R. E. Cutler, A. W. Forrey, T. G. Christopher, and B. M. Kimpel. Pharmacokinetics of furosemide in normal subjects and functionally anephric patients.Clin. Pharmacol. Ther.15:588–596 (1974). CASPubMed Google Scholar
S. Kojima, R. B. Smith, and J. T. Doluisio. Drug absorption. V. Influence of food on oral absorption of phenobarbital in rats.J. Pharm. Sci.60:1639–1641 (1971). ArticleCASPubMed Google Scholar
S. Kojima. Factors influencing absorption and excretion of drugs. I. Effect of food on gastrointestinal absorption of amobarbital in rats.Chem. Pharm. Bull.21:2432–2437 (1973). ArticleCASPubMed Google Scholar
J. M. Orr and L. Z. Benet. The effect of fasting on the rate of intestinal drug absorption in rats: Preliminary studies.Am. J. Digest. Dis.20:858–865 (1975). ArticleCASPubMed Google Scholar
P. G. Welling, L. L. Lyons, W. A. Craig, and G. A. Trochta. Influence of diet and fluid on bioavailability of theophylline.Clin. Pharmacol. Ther.17:475–480 (1975). CASPubMed Google Scholar
P. A. Mitenko and R. I. Ogilvie. Pharmacokinetics of intravenous theophylline.Clin. Pharmacol. Ther.14:509–513 (1973). CASPubMed Google Scholar
An annotated list of drugs with potential for therapeutic inequivalence based on current evidence of drug product bioavailabiiity inequivalence.J. Am. Pharm. Assoc.NS13:279–280 (1972).
A. V. Tembo, E. Sakmar, M. R. Hallmark, D. J. Weidler, and J. G. Wagner. Effect of food on the bioavailability of prednisone.J. Clin. Pharmacol.16:620–624 (1976). ArticleCASPubMed Google Scholar
J. M. Tukey. Comparing individual means in the analysis of variance.Biometrics5:99–114 (1949). ArticleCASPubMed Google Scholar
R. G. Crounse. Human pharmacology of griseofulvin: The effect of fat intake on gastrointestinal absorption.J. Invest. Dermatol.37:529–533 (1961). ArticleCASPubMed Google Scholar
P. Kabasakalian, M. Katz, B. Rosenkrantz, and E. Townley. Parameters affecting absorption of griseofulvin in a human subject using urinary metabolite excretion data.J. Pharm. Sci.59:595–600 (1970). ArticleCASPubMed Google Scholar
T. R. Bates, M. Gibaldi, and J. L. Kanig. Solubilizing properties of bile salt solutions. I. Effect of temperature and bile salt concentration on solubilization of glutethimide, griseofulvin and hexestrol.J. Pharm. Sci.55:191–199 (1966). ArticleCASPubMed Google Scholar
T. R. Bates, M. Gibaldi, and J. L. Kanig. Solubilizing properties of bile salt solutions. II. Effect of inorganic electrolyte, lipids, and a mixed bile salt system on solubilization of glutethimide, griseofulvin and hexestrol.J. Pharm. Sci.55:901–906 (1966). ArticleCASPubMed Google Scholar
T. R. Bates, J. A. Sequeira, and A. V. Tembo. Effect of food on nitrofurantoin absorption.Clin. Pharmacol. Ther.16:63–68 (1974). CASPubMed Google Scholar
P. G. Welling, L. L. Lyons, F. L. S. Tse, and W. A. Craig. Propoxyphene and norpropoxyphene: Influence of diet and fluid on plasma levels.Clin. Pharmacol. Ther.19:559–565 (1975). Google Scholar
J. G. Wagner, P. G. Welling, S. B. Roth, E. Sakmar, K. P. Lee, and J. E. Walker. Plasma concentrations of propoxyphene in man. I. Following oral administration of drug in solution and capsule forms.Int. J. Clin. Pharmacol.5:371–380 (1972). CAS Google Scholar
G. Levy and W. J. Jusko. Factors affecting the absorption of riboflavin in man.J. Pharm. Sci.55:285–289 (1966). ArticleCASPubMed Google Scholar
W. J. Jusko and G. Levy. Absorption, metabolism and excretion of riboflavin-5'-phosphate in man.J. Pharm. Sci.56:58–62 (1967). ArticleCASPubMed Google Scholar
J. Jeppson and J. Sjögren. The influence of food on side effects and absorption of lithium.Acta Psychiat. Scand.51:285–288 (1975). Article Google Scholar
W. J. Jusko and G. P. Lewis. Comparison of ampicillin and hetacillin pharmacokinetics in man.J. Pharm. Sci.62:69–76 (1973). ArticleCASPubMed Google Scholar
R. Sutherland and O. P. W. Robinson. Laboratory and pharmacological studies in man with hetacillin and ampicillin.Br. Med. J.2:804–808 (1967). ArticleCASPubMed CentralPubMed Google Scholar
J. M. McGuire, R. L. Bunch, R. C. Anderson, H. E. Boaz, H. E. Flynn, H. M. Powell, and J. W. Smith. “Ilotycin,” a new antibiotic.Antibiot. Chemother.2:281–283 (1952). CAS Google Scholar
L. E. Josselyn and J. C. Sylvester. Absorption of erythromycin.Antibiot. Chemother.3:63–66 (1952). Google Scholar
J. W. Smith, R. W. Dyke, and R. S. Griffith. Absorption following oral administration of erythromycin.J. Am. Med. Assoc.151:805–810 (1953). CASPubMed Google Scholar
A. R. DiSanto. Bioavailability data: Protocols CS 071 and CS 076, Upjohn Co., Kalamazoo, Mich., 1976. Google Scholar
H. A. Hirsch and M. Finland. Effect of food on the absorption of erythromycin propionate, erythromycin stearate and triacetyloleandomycin.Am. J. Med. Sci.237:693–708 (1959). ArticleCASPubMed Google Scholar
W. E. Clapper, M. Mostyn, and G. H. Meade. An evaluation of erythromycin stearate and propionyl erythromycin in normal and hospitalized subjects.Antibiot. Med. Clin. Ther.7:91–96 (1960). CAS Google Scholar
P. G. Welling. Unpublished data.
R. S. Griffith and H. R. Black. Comparison of the blood levels obtained after single and multiple doses of erythromycin estolate and erythromycin stearate.Am. J. Med. Sci.247:69–74 (1964). ArticleCASPubMed Google Scholar
J. C. Sylvester and L. E. Josselyn. Absorption of erythromycin. II. Erythromycin stearate.Antibiot. Chemother.3:930–932 (1953). CAS Google Scholar
R. S. Griffith, M. Joiner, and H. Kottlowski. Comparison of antibacterial activity in the sera of subjects ingesting propionyl erythromycin lauryl sulfate and erythromycin ethyl carbonate.Antibiot. Med. Clin. Ther.7:320–326 (1960). CAS Google Scholar
H. A. Hirsch, C. V. Pryles, and M. Finland. Effect of food on absorption of a new form of erythromycin propionate.Am. J. Med. Sci.239:198–202 (1960). ArticleCASPubMed Google Scholar
Bioavailability data: Studies 73–190 and 75–103, Abbott Laboratories, North Chicago, 1976.
R. G. Wiegand and A. H. C. Chun. Serum protein binding of erythromycin and erythromycin-2′-propionate ester.J. Pharm. Sci.61:425–428 (1972). ArticleCASPubMed Google Scholar
K.-Y. Tserng and J. G. Wagner. Fluorometric determination of erythromycin and erythromycin propionate in whole blood or plasma and correlation of results with microbiological assay.Anal. Chem.48:348–353 (1976). ArticleCASPubMed Google Scholar
Y.-J. Lin, D. J. Weidler, D. C. Garg, and J. G. Wagner. Effects of solid food on blood levels of alcohol in man.Res. Commun. Chem. Pathol. Pharmacol.13:713–722 (1976). CASPubMed Google Scholar
J. G. Wagner, P. K. Wilkinson, A. J. Sedman, D. R. Kay, and D. J. Weidler. Elimination of alcohol from human blood.J. Pharm. Sci.65:152–154 (1976). ArticleCASPubMed Google Scholar
P. G. Welling, L. L. Lyons, R. Elliott, and G. L. Amidon. Pharmacokinetics of alcohol following single low doses to fasted and nonfasted subjects.J. Clin. Pharmacol.17:199–206 (1977). ArticleCASPubMed Google Scholar
A. R. Cooke. The simultaneous emptying and absorption of alcohol from the human stomach.Am. J. Digest. Dis.15:449–454 (1970). ArticleCASPubMed Google Scholar
H. W. Haggard, L. A. Greenberg, and G. Lolli. The absorption of alcohol with special reference to its influence on the concentration of alcohol appearing in the blood.Quart. J. Stud. Alcohol1:684–726 (1941). CAS Google Scholar
A. Krondl. Present understanding of the interaction of drugs and food during absorption.Can. Med. Assoc. J.103:360–364 (1970). CASPubMed CentralPubMed Google Scholar