Size of neurons and glial cells in the enteric ganglia of mice, guinea-pigs, rabbits and sheep (original) (raw)
Summary
A quantitative light microscopic study has been carried out on the myenteric and submucosal ganglia of the stomach, duodenum, ileum, proximal colon and rectum of the guinea-pig; the enteric ganglia of the ileum were studied also in the mouse, rabbit and sheep. The area of the profiles of nerve cells, of nerve cell nuclei and of glial nuclei, and the proportion of the area of ganglia occupied by neuropil were measured, and the relative numbers of neurons and glial cells were estimated. The myenteric ganglia were found to be firmly anchored to the stroma of the muscle coat; their shape and the shape of their component cells varied with contraction and distension of the musculature. The range of neuronal sizes in the myenteric ganglia was extremely wide. In the guinea-pig, the myenteric neurons were on average largest in the stomach and duodenum and smallest in the ileum, with intermediate values in the colon and rectum; the submucosal neurons showed little variation in average size along the length of the gut. The average size of ganglion neurons in the ileum was greatest in the sheep and smallest in the mouse, and had intermediate values in the guinea-pig and rabbit. The percentage volume of neuropil in the myenteric ganglia was 51% in the mouse, 65% in the guinea-pig, 70% in the rabbit, and 74% in the sheep. The number of glial cells relative to the number of neurons was also ranked in the same order. In all the species examined the submucosal ganglia, when compared with the corresponding myenteric ganglia, had a smaller percentage volume of neuropil, a much smaller number of glial cells and (except in the mouse ileum) neurons of smaller average size. In all the ganglia there was a positive correlation between size of neurons and size of glial cells. The results are discussed in the light of possible relations between body size (and length of the intestine), numerical density of ganglion neurons, average size of neurons, amount of musculature, average distance between neurons, and amount of neuropil.
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References
- Dupont, J. -R., Jervis, H. R. &Sprinz, H. (1965) Auerbach's plexus of the rat cecum in relation to the germfree state.Journal of Comparative Neurology 125, 11–18.
Google Scholar - Furness, J. B. &Costa, M. (1980) Types of nerves in the enteric nervous system.Neuroscience 5, 1–20.
PubMed Google Scholar - Gabella, G. (1971) Neuron size and number in the myenteric plexus of the newborn and adult rat.Journal of Anatomy 109, 81–95.
PubMed Google Scholar - Gabella, G. (1981) On the musculature of the gastro-intestinal tract of the guinea-pig.Anatomy and Embryology 163, 135–56.
Google Scholar - Gabella, G. (1982) Structure of muscles and nerves in the gastrointestinal tract. In_Physiology of the Gastrointestinal Tract_ (edited byJohnson, L. L.), pp. 197–241. New York: Raven Press.
Google Scholar - Gabella, G. (1984) Size of neurons and glial cells in the intramural ganglia of the hypertrophic intestine of the guinea-pig.Journal of Neurocytology 13, 73–84.
PubMed Google Scholar - Gershon, M. D. &Erde, S. M. (1981) The nervous system of the gut.Gastroenterology 80, 1571–94.
PubMed Google Scholar - Gunn, M. (1968) Histological and histochemical observations on the myenteric and submucous plexuses of mammals.Journal of Anatomy 102, 223–39.
PubMed Google Scholar - Hendry, I. A. &Campbell, J. (1976) Morphometric analysis of rat superior cervical ganglion after axotomy and nerve growth factor treatment.Journal of Neurocytology 5, 351–60.
PubMed Google Scholar - Henneman, E., Somjen, G. &Carpenter, D. O. (1964) Functional significance of cell size in spinal motoneurons.Journal of Neurophysiology 28, 560–80.
Google Scholar - Irwin, D. A. (1931) The anatomy of Auerbach's plexus.American Journal of Anatomy 49, 141–66.
Google Scholar - Konigsmark, B. W. (1970) Methods for the counting of neurons. In_Contemporary Research Methods in Neuroanatomy_ (edited byNauta, W. J. H. andEbbeson, S. O. E.), pp. 315–80. New York: Springer Verlag.
Google Scholar - Matsuo, H. (1934) A contribution on the anatomy of Auerbach's plexus.Japanese Journal of Medical Sciences. I. Anatomy 4, 417–28.
Google Scholar - Matthews, M. R. (1974) Ultrastructure of ganglionic junctions. In_The Peripheral Nervous System_ (edited byHubbard, J. I.) pp. 111–50. New York: Plenum Press.
Google Scholar - Ohkubo, K. (1936a) Studies on the intrinsic nervous system of the digestive tract. The submucous plexus of the guinea-pig.Japanese Journal of Medical Sciences. I. Anatomy 6, 1–20.
Google Scholar - Ohkubo, K. (1936b) Studien über das intramurale Nervensystem des Verdauungskanals. II. Die Plexus myentericus und Plexus subserosus des Meerschweinchens.Japanese Journal of Medical Sciences. I. Anatomy 6, 21–37.
Google Scholar - Prestige, M. C. (1974) Axon and cell numbers in the developing nervous system.British Medical Bulletin 30, 107–11.
PubMed Google Scholar - Stöhr, P. Jr (1930) Mikroskopische Studien zur Innervation des Magen-Darmkanales.Zeitschrift für Zellforschung und mikroskopische Anatomie 12, 66–154.
Google Scholar - Tafuri, W. I. (1957) Auerbach's plexus in the guinea-pig. I. A quantitative study of the ganglia and nerve cells in the ileum, caecum and colon.Acta anatomica 31, 522–30.
PubMed Google Scholar - Tafuri, W. L. &Almeida Campos, F. D. (1958) Der Auerbachsche Plexus bei der Maus.Zeitschrift für Naturforschung 13b, 816–19.
Google Scholar - Wilson, A. J., Furness, J. B. &Costa, M. (1981) The fine structure of the submucous plexus of the guinea-pig ileum. I. The ganglia, neurons, Schwann cells and neuropil.Journal of Neurocytology 10, 759–84.
PubMed Google Scholar - Wood, J. D. (1981) Physiology of the enteric nervous system. In_Physiology of the Gastrointestinal Tract_ (edited byJohnson, L. L.), pp. 1–37. New York: Raven Press.
Google Scholar
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- Department of Anatomy, University College London, WC1E 6BT, UK
Giorgio Gabella & Peter Trigg
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- Giorgio Gabella
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Gabella, G., Trigg, P. Size of neurons and glial cells in the enteric ganglia of mice, guinea-pigs, rabbits and sheep.J Neurocytol 13, 49–71 (1984). https://doi.org/10.1007/BF01148318
- Received: 30 March 1983
- Revised: 14 July 1983
- Accepted: 29 July 1983
- Issue Date: February 1984
- DOI: https://doi.org/10.1007/BF01148318