Abnormalities in lipogenesis and triglyceride secretion by perfused livers of obese-hyperglycaemic (ob/ob) mice: Relationship with hyperinsulinaemia (original) (raw)

References

  1. Shigeta, Y., Shreeve, W. W.: Fatty acid synthesis from glucose-1-3H and gluoose-1-14C in obese hyperglycaemic mice. Amer. J. Physiol.206, 1085–1090 (1964)
    Google Scholar
  2. Bates, M. W., Zomzely, C., Mayer, J.: Fat metabolism in three forms of experimental obesity. IV. Instantaneous rates of lipogenesis_in vivo_. Amer. J. Physiol.181, 187–190 (1955)
    Google Scholar
  3. Jansen, G.R., Zanetti, M.E., Hutchison, C.F.: Studies on lipogenesis_in vivo._ Fatty acid and cholesterol synthesis in hyperglycaemic-obese mice. Biochem. J.102, 870–877 (1967)
    Google Scholar
  4. Winand, J.: Aspects qualitatifs et quantitatifs du métabolisme lipidique de la souris normale et de la souris congénitalement obèse. Bruxelles: Editions Arscia S.A. 1970
  5. Bray, G.A., York, D.A.: Genetically transmitted obesity in rodents. Physiol. Rev.51, 598–646 (1971)
    Google Scholar
  6. Chang, H.C., Seidman, I., Teebor, G., Lane, M.D.: Liver acetyl CoA carboxylase and fatty acid synthetase: relative activities in the normal state and in hereditary obesity. Biochem. biophys. Res. Commun.28, 682–686 (1967)
    Google Scholar
  7. Kornacker, M.S., Lowenstein, J.M.: Citrate cleavage enzyme in livers of obese and non obese mice. Science144, 1027–1028 (1964)
    Google Scholar
  8. Assimacopoulos-Jeannet, F., Exton, J.H., Jeanrenaud, B.: Control of gluconeogenesis and glycogenolysis in perfused livers of normal mice. Amer. J. Physiol.225, 25–32 (1973)
    Google Scholar
  9. Chen, R.F.: Removal of fatty acids from serum albumin by charcoal treatment. J. biol. Chem.242, 173–181 (1967)
    Google Scholar
  10. Le Marchand, Y., Singh, A., Assimacopoulos-Jeannet, F., Orci, L., Rouiller, Ch., Jeanrenaud, B.: A role for the microtubular system in the release of very low density lipoproteins by perfused mouse livers. J. biol. Chem.248, 6862–6870 (1973)
    Google Scholar
  11. Hohorst, H.J.: Methods of enzymatic analysis, pp. 266–270. (Ed. Bergmeyer, H.U.). Weinheim-New York-London: Verlag Chemie and Academic Press 1963
    Google Scholar
  12. Bücher, T., Czok, R., Lamprecht, W., Latzko, E.: Methods of enzymatic analysis, pp. 253–259. (Ed. Bergmeyer, H.U.). Weinheim-New York-London Verlag Chemie and Academic Press 1963
    Google Scholar
  13. Mellanby, J., Williamson, D.H.: Methoden der Enzymatischen Analyse, pp. 1776–1779. (Ed. Bergmeyer, H.U.). Ed. 2. Weinheim: Verlag Chemie 1970
    Google Scholar
  14. Williamson, D.H., Mellanby, J.: Methoden der Enzymatischen Analyse, pp. 1772–1775. (Ed. Bergmeyer, H.U.). Ed. 2. Weinheim: Verlag Chemie 1970
    Google Scholar
  15. Ho, R.J.: Radiochemical assay of long chain fatty acids using63Ni as tracer. Analyt. Biochem.36, 105–113 (1970)
    Google Scholar
  16. Heindel, J.J., Cushman, S.W., Jeanrenaud, B.: Cell associated fatty acid levels and energy-requiring processes in mouse adipocytes. Amer. J. Physiol.224, 16–24 (1974)
    Google Scholar
  17. Folch, J., Lees, M., Sloane-Stanley, G.H.: A simple method for the isolation and purification of total lipids from animal tissues. J. biol. Chem.226, 497–509 (1957)
    Google Scholar
  18. Abraham, R.R., Dade, E., Elliott, J., Hems, D.A.: Hormonal control of intermediary metabolism in obese hyperglycemic mice. II. Levels of plasma free fatty acid and immunoreactive insulin and liver glycogen. Diabetes20, 535–541 (1971)
    Google Scholar
  19. Seidman, I., Horland, A.A., Teebor, G. W.: Glycolytic and gluconeogenic enzyme activities in the hereditary obese-hyperglycemic syndrome and in acquired obesity. Diabetologia6, 313–316 (1970)
    Google Scholar
  20. Jungas, R.L.: Fatty acid synthesis in adipose tissue incubated in tritiated water. Biochemistry7, 3708–3717 (1968)
    Google Scholar
  21. Brunengraber, H., Boutry, M., Lowenstein, J.M.: Fatty acid and 3-β-hydroxysterol synthesis in the perfused rat liver. J. biol. Chem.248, 2656–2669 (1973)
    Google Scholar
  22. Kohout, M., Kohoutova, B., Heimberg, M.: The effect of chain length and degree of unsaturation of the fatty acid substrate on the output of triglycerides by the liver. Biochim. biophys. Acta (Amst.)210, 177–179 (1970)
    Google Scholar
  23. Nikkilä, E. A.: Control of plasma and liver triglyceride kinetics by carbohydrate metabolism and insulin. Advances Lipid Res.7, 63–134 (1969)
    Google Scholar
  24. Lowenstein, J.M.: Is insulin involved in regulating the rate of fatty acid synthesis? In: Handbook of Physiology. Section 7: Endocrinology. Vol. 1. Endocrine pancreas, pp. 415–424. (Eds. Greep, R.O., Astwood, E.B.). Amer. Physiol. Soc, Washington D.C. 1972
    Google Scholar
  25. Topping, D.L., Mayes, P.A.: The immediate effects of insulin and fructose on the metabolism of the perfused liver. Changes in lipoprotein secretion, fatty acid oxidation and esterification, lipogenesis and carbohydrate metabolism. Biochem. J.126, 295–311 (1972)
    Google Scholar
  26. Letarte, J., Fraser, T. R.: Stimulation by insulin of the incorporation of U14C-glucose into lipids released by the liver. Diabetologia5, 358–359 (1969)
    Google Scholar
  27. Hetenyi, G., Norwich, K.H., Studney, D.R., Hall, J. D.: The exchange of glucose across the liver cell membrane. Can. J. Physiol. Pharmacol.47, 361–367 (1969)
    Google Scholar
  28. Takeda, Y., Inoue, H., Honjo, K., Tanioka, H., Daikuhara, Y.: Dietary response of various key enzymes related to glucose metabolism in normal and diabetic rat liver. Biochim. biophys. Acta (Amst.)136, 214–222 (1967)
    Google Scholar
  29. Elliott, J., Hems, D.A., Beloff-Chain, A.: Carbohydrate metabolism of the isolated perfused liver of normal and genetically obese-hyperglycaemic (objob) mice. Biochem. J.125, 773–780 (1971)
    Google Scholar

Download references