Hyperinsulinemia in pre-weaning diabetes (db) mice (original) (raw)

Summary

Two new strains of diabetes mice (C57BL/ KsJ-m db and C57BL/6J-m db) have been developed with diabetes (db) and the closely linked misty (m) gene coupled on the same chromosome. This permits identification of diabetes mice (m db/m db) by their gray coat color and white feet as early as age 4 days, well before obesity or signs of diabetes are visible. Hyperinsulinemia was evident in diabetes mice of both strains at 10 days of age and the severity increased progressively with age. These elevated concentrations of plasma insulin were associated with mild hypoglycemia. No significant differences were observed with respect to the degrees of hyperinsulinemia or hypoglycemia between diabetes mice of the two strains. The mild hypoglycemia observed in diabetes mice in the presence of a pronounced hyperinsulinemia suggests that insulin resistance occurs as early as age 10 days and may itself be a factor in causing hyperinsulinemia. The sequence of early events occurring in diabetes mice appears to be hyperinsulinemia leading to mild hypoglycemia, followed by compensatory hyperphagia which in turn results in enhanced insulin secretion and obesity.

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  1. Coleman, D.L.: Effects of parabiosis of obese with diabetes and normal mice. Diabetologia9, 294–298 (1973)
    PubMed Google Scholar
  2. Coleman, D.L., Hummel, K.P.: Studies with the mutation, diabetes, in the mouse. Diabetologia3, 238–248 (1967)
    PubMed Google Scholar
  3. Coleman, D.L., Hummel, K.P.: The mutation, diabetes, in the mouse. Proc. of the VIth Congress of the Int. Diabetes Federation. Excerpta med. Ser.172, 813–820 (1968)
    Google Scholar
  4. Coleman, D.L., Hummel, K.P.: The influence of genetic background on the expression of the obese gene (ob) in the mouse. Diabetologia9, 287–293 (1973)
    PubMed Google Scholar
  5. Genuth, S.M., Przybylski, R.J., Rosenberg, D.M.: Insulin resistance in genetically obese, hyperglycemic mice. Endocrinology88, 1230–1236 (1971)
    PubMed Google Scholar
  6. Hummel, K.P., Coleman, D.L., Lane, P.W.: The influence of genetic background on the expression of mutations at the diabetes locus in the mouse. Biochem. Genet.7, 1–13 (1972)
    PubMed Google Scholar
  7. Joosten, H.F.P., van der Kroon, P.H.W.: Enlargment of epididymal adipocytes in relation to hyperinsulinemia in obese hyperglycemic mice (ob/ob). Metabolism23, 59–66 (1974)
    PubMed Google Scholar

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Authors and Affiliations

  1. The Jackson Laboratory Bar Harbor, 04609, Maine, USA
    D. L. Coleman & Katharine P. Hummel

Authors

  1. D. L. Coleman
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  2. Katharine P. Hummel
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Supported in part by NTH Research Grant AM 14461 from the National Institute of Arthritis, Metabolism, and Digestive Diseases.

The Jackson Laboratory is fully accredited by the American Association for Accreditation of Laboratory Animal Care.

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Coleman, D.L., Hummel, K.P. Hyperinsulinemia in pre-weaning diabetes (db) mice.Diabetologia 10 (Suppl 1), 607–610 (1974). https://doi.org/10.1007/BF01221993

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