Randomized study of chemoembolization as an adjuvant therapy for primary liver carcinoma after hepatectomy (original) (raw)

Abstract

From April 1990 to December 1993, 140 patients were recruited to a randomized study to evaluate transcatheter hepatic arterial chemoembolization (TACE) as an adjuvant therapy for primary liver carcinoma after hepatectomy. This study investigated the principle, techniques and results of TACE. The results showed that the intrahepatic recurrence rate was 48.9% in the patients who underwent radical resection only, but only 21.3% in the patients who also underwent TACE 3–4 weeks after hepatectomy (P<0.01). The 1-, 2-, 3-, and 4-year survival rates were 72.3%, 52.7%, 35.1%, and 35.1% respectively for the patients who underwent radical resection only, and were 97.9%, 85.5%, 69.5%, and 56.9% for the patients who also underwent TACE 3–4 weeks after radical resection_P_<0.001). The 1-, 2-, 3-, and 4-year survival rates were 38.9%, 0%, 0%, and 0% for the patients who underwent palliative resection only, and were 68.3%, 32.3%, 21.5%, and 21.5% respectively for the patients undergoing TACE 3–4 weeks after palliative hepatectomy_P_<0.001).

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Abbreviations

TACE :

transcatheter hepatic arterial chemoembolization

PLC :

primary liver carcinoma

References

• Kojiro M, Nakashima T (1987) Pathology of hepatocellular carcinoma. In: Okuda K (ed) Neoplasms of the liver. Springer, Tokyo Berlin Heidelberg New York, pp 353–104
  Google Scholar
• Li GH, Li JQ (1989) Subclinical primary liver carcinoma. J Surg Oncol 42: 181–183
  PubMed Google Scholar
• Nagasue N, Galizia G, Kohno H, et al (1989) Adverse effects of preoperative hepatic artery chemoembolization for resectable hepatocellular carcinoma: a restrospective comparison of 138 liver resections. Surgery 106: 81–86
  PubMed Google Scholar
• Tang ZY (1985) Subclinical hepatocellular carcinoma historical aspects and general consideration. In: Tang ZY (ed) Subclinical hepatocellular carcinoma. Springer, Berlin Heidelberg New York Tokyo, pp 1–11
  Google Scholar
• Wu MC, Chen H, Zhang XH (1984) Hepatic resection: a 24-year experience (in Chinese). Acta Acad Med Wuhan 6: 379–383
  Google Scholar
• Yamanaka N, Okmoto, Toyosaka A, et al (1990) Prognostic factors after hepatectomy for hepatocellular carcinomas. A univariate and multivariate analysis. Cancer 65: 1104–1110
  PubMed Google Scholar
• Yuki K, Hirohashi S, Sakamoto M, et al (1990) Growth and spread of hepatocellular carcinoma. Cancer 66:2174–2179
  PubMed Google Scholar

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Authors and Affiliations

1. Department of Abdominal Surgery, Tumor Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou, P. R. China
   Jin-qing Li, Ya-qi Zhang, Wei-zhang Zhang, Yun-fei Yuan & Guo-hui Li

Authors

1. Jin-qing Li
2. Ya-qi Zhang
3. Wei-zhang Zhang
4. Yun-fei Yuan
5. Guo-hui Li

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Li, Jq., Zhang, Yq., Zhang, Wz. et al. Randomized study of chemoembolization as an adjuvant therapy for primary liver carcinoma after hepatectomy.J Cancer Res Clin Oncol 121, 364–366 (1995). https://doi.org/10.1007/BF01225689

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• Received: 05 August 1994
• Accepted: 03 January 1995
• Issue date: June 1995
• DOI: https://doi.org/10.1007/BF01225689

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