Foreign-protein-mediated immunodeficiency in hemophiliacs with and without HIV (original) (raw)
References
AIDS-Hemophilia French Study Group, 1985. Immunologic and virologic status of multitransfused patients: Role of type and origin of blood products. Blood 66: 896–901. Google Scholar
Aledort, L.M., 1988. Blood products and immune changes: impacts without HIV infection. Sem. Hematol. 25: 14–19. Google Scholar
Anderson, R.M. & R.M. May, 1988. Epidemiological parameters of HIV transmission. Nature (London) 333: 514–519. Google Scholar
Anonymous, 1984. The cause of AIDS? Lancet i: 1053–1054.
Antonaci, S., E. Jirillo, D. Stasi, V. De Mitrio, M.R. La Via & L. Bonomo, 1988. Immunoresponsiveness in hemophilia: Lymphocyte-and Phagocyte-mediated functions. Diagn. Clin. Immunol. 5: 318–325. PubMed Google Scholar
Aronson, D.L., 1983. Pneumonia deaths in haemophiliacs. Lancet ii: 1023. Google Scholar
Associated Press, 1994. Red Cross knew of AIDS blood threat. San Francisco Chronicle, May, 16.
Auerbach, D.M., W.W. Darrow, H.W. Jaffe & J.W. Curran, 1984. Cluster of cases of the Acquired Immune Deficiency Syndrome patients linked by sexual contact. Am. J. Med. 76: 487–492. PubMed Google Scholar
Bagasra, O., S.P. Hauptman, H.W. Lischner, M. Sachs & R.J. Pomerantz, 1992. Detection of human immunodeficiency virus type 1 provirus in mononuclear cells by in situ polymerase chain reaction. N. Engl. J. Med. 326: 1385–1391. PubMed Google Scholar
Becherer, P.R., M.L. Smiley, T.J. Matthews, K.J. Weinhold, C.W. McMillan & G.C.I. White, 1990. Human immunodeficiency virus-1 disease progression in hemophiliacs. Am. J. Hematol. 34: 204–209. PubMed Google Scholar
Biggar, R.J. & the International Registry of Seroconverters, 1990. AIDS incubation in 1891 HIV seroconverters from different exposure groups. AIDS 4: 1059–1066. PubMed Google Scholar
Blattner, W.A., (1991). HIV epidemiology: past, present, and future. FASEB J. 5: 2340–2348. PubMed Google Scholar
Blattner, W.A., R.C. Gallo & H.M. Temin, 1988. HIV causes AIDS. Science 241: 514–515. PubMed Google Scholar
Booth, W., 1988. A rebel without a cause for AIDS. Science 239: 1485–1488. PubMed Google Scholar
Brettler, D.B., A.D. Forsberg, F. Brewster, J.L. Sullivan & P.H. Levine, 1986. Delayed cutaneous hypersensitivity reactions in hemophiliac subjects treated with factor concentrate. Am. J. Med. 81: 607–611. PubMed Google Scholar
Brettler, D.B. & P.H. Levine, 1989. Factor concentrates for treatment of hemophilia: which one to choose? Blood 73: 2067–2073. PubMed Google Scholar
Cairns, J., 1978. Cancer: Science and Society. W.H. Freeman and Company, San Francisco. Google Scholar
Carr, R., E. Edmond, R.J. Prescott, S.E. Veitch, J.F. Peutherer & C.M. Steel, 1984. Abnormalities of circulating lymphocyte subsets in haemophiliacs in an AIDS-free population. Lancet i: 1431–1434. Google Scholar
Centers for Disease Control, 1982. Pneumocystis carinii pneumonia among persons with hemophilia A. Morbid. Mort. Weekly Report 31: 365–367. Google Scholar
Centers for Disease Control (eds), 1986. Reports on AIDS published in the Morbidity and Mortality Weekly Report, June 1981 through February 1986.
Centers for Disease Control and Prevention, 1994.HIV/AIDS Surveillance Report, Year-end Edition 4: 1–33. Google Scholar
U.S. Dept. of Health and Human Services, National Technical Information Service, Springfield, VA.
Centers for Disease Control, 1992a. HIV/AIDS Surveillance Report — January Issue.
Centers for Disease Control, 1992b. The second 100,000 cases of Acquired Immunodeficiency Syndrome — United States, June 1981-December 1991. Morbid. Mort. Weekly Report 41: 28–29. Google Scholar
Centers for Disease Control and Prevention, 1992. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. Morb. Mort. Weekly Rep. 41 (No. RR17) 1–19. Google Scholar
Chorba, T.L., R.C. Holman, T.W. Strine, M.J. Clarke & B.L. Evatt, 1994. Changes in longevity and causes of death among persons with hemophilia A. Am. J. Hematol. 45: 112–121. PubMed Google Scholar
Cohen, J., 1993. Keystone's blunt message: 1 It's the virus, stupid'. Science 260: 292–293. PubMed Google Scholar
Curran, J.W., M.W. Morgan, A.M. Hardy, H.W. Jaffe, W.W. Darrow & W.R. Dowdle, 1985. The epidemiology of AIDS: current status and future prospects. Science 229: 1352–1357. PubMed Google Scholar
Darby, S.C., C.R. Rizza, R. Doll, R.J.D. Spooner, I.M. Stratton & B. Thakrar, 1989. Incidence of AIDS and excess mortality associated with HIV in haemophiliacs in the United Kingdom: report on behalf of the directors of haemophilia centers in the United Kingdom. Br. Med. J. 298: 1064–1068. Google Scholar
de Biasi, R., A. Rocino, E. Miraglia, L. Mastrullo & A.A. Quirino, 1991. The impact of a very high purity of factor VIII concentrate on the immune system of human immunodeficiency virus-infected hemophiliacs: a randomized, prospective, two-year comparison with an intermediate purity concentrate. Blood 78: 1919–1922. PubMed Google Scholar
Detels, R., P.A. English, J.V. Giorgi, B.R. Visscher, J.L. Fahey, J.M.G. Taylor, J.P. Dudley, P. Nishanian, A. Munoz, J.P. Phair, B.F. Polk & C.R. Rinaldo, 1988. Patterns of CD4+ cell changes after HIV-1 infection indicate the existence of a codeterminant of AIDS. Journal of Acquired Immune Deficiency Syndromes 1: 390–395. PubMed Google Scholar
Dickson, D., 1994. Critic still lays blame for AIDS on lifestyle, not HIV. Nature (London) 369: 434. Google Scholar
Duesberg, P.H., 1990. Quantification of human immunodeficiency virus in the blood. N. Engl. J. Med. 322: 1466. PubMed Google Scholar
Duesberg, P.H., 1991. AIDS epidemiology: inconsistencies with human immunodeficiency virus and with infectious disease. Proc. Natl. Acad. Sci. USA 88: 1575–1579. PubMed Google Scholar
Duesberg, P.H., 1992a. AIDS acquired by drug consumption and other noncontagious risk factors. Pharmacology & Therapeutics 55: 201–277. Google Scholar
Duesberg, P.H., 1992b. HIV as target for zidovudine. Lancet 339: 551. Google Scholar
Duesberg, P.H., 1992c. HIV, AIDS, and zidovudine. Lancet 339: 805–806. PubMed Google Scholar
Fauci, A.S., 1993. CD4+ T-lymphocytopenia without HIV infection — no lights, no camera, just facts. N. Engl. J. Med. 328: 429–431. PubMed Google Scholar
Fields, B.N., 1994. AIDS: time to turn to basic science. Nature (London) 369: 95–96. Google Scholar
Fischl, M.A., D.D. Richman, M.H. Grieco, M.S. Gottlieb, P.A. Volberding, O.L. Laskin, J.M. Leedon, J.E. Groopman, D. Mildvan, R.T. Schooley, G.G. Jackson, D.T. Durack, D. King & the AZT Collaborative Working Group, 1987. The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. N. Engl. J. Med. 317: 185–191. PubMed Google Scholar
Fletcher, M.A., J.W. Mosley, J. Hassett, G.F. Gjerset, J. Kaplan, J.W. Parker, E. Donegan, J.M. Lusher, H. Lee & Transfusion Safety Study Group, 1992. Effect of Age on Human Immunodeficiency Virus Type 1-Induced Changes in Lymphocyte Populations Among Persons with Congenital Clotting Disorders. Blood 80: 831–840. PubMed Google Scholar
Froebel, K.S., R. Madhok, C. Forbes, S.E. Lennie, G.D. Lowe & R.D. Sturrock, 1983. Immunological abnormalities in haemophilia: are they caused by American factor VIII concentrate? Br. Med. J. 287: 1091–1093. Google Scholar
Gill, J.C., M.D. Menitove, P.R. Anderson, J.T. Casper, S.G. Devare, C. Wood, S. Adair, J. Casey, C. Scheffel & M.D. Montgomery, 1986. HTLV-III serology in hemophilia: Relationship with immunologic abnormalities. J. Pediatr. 108: 511–516. PubMed Google Scholar
Gjerset, G.F., M.C. Pike, J.W. Mosley, J. Hassett, M.A. Fletcher, E. Donegan, J.W. Parker, R.B. Counts, Y. Zhou, C.K. Kasper, E.A. Operskalski & The Transfusion Safety Study Group, 1994. Effect of Low- and Intermediate-Purity Clotting Factor Therapy on Progression of Human Immunodeficiency Virus Infection in Congenital Clotting Disorders. Blood 84: 1666–1671. PubMed Google Scholar
Goedert, J.J., C.M. Kessler, L.M. Aledort, R.J. Biggar, W.A. Andes, G.C. White II, J.E. Drummond, K. Vaidya, D.L. Mann, M.E. Eyster, M.V. Ragni, M.M. Lederman, A.R. Cohen, G.L. Bray, P.S. Rosenberg, R.M. Friedman, M.W. Hilgartner, W.A. Blattner, B. Kroner & M.H. Gail, 1989. A prospective study of human immunodeficiency virus type 1 infection and the development of AIDS in subjects with hemophilia. N. Engl. J. Med. 321: 1141–1148. PubMed Google Scholar
Goedert, J.J., A.R. Cohen, C.M. Kessler, S. Eichinger, S.V. Seremetis, C.S. Rabkin, F.J. Yellin, P.S. Rosenberg & L.M. Aledort, 1994. Risks of immunodeficiency, AIDS, and death related to purity of factor VIII concentrate. Lancet 344: 791–792. PubMed Google Scholar
Goldsmith, J.M., J. Deutsche, M. Tang & D. Green, 1991. CD4 Cells in HIV-1 Infected Hemophiliacs: Effect of Factor VIII Concentrates. Thromb. Haemost. 66: 415–419. PubMed Google Scholar
Gomperts, E.D., R. De Biasi & R. De Vreker, 1992. The Impact of Clotting Factor Concentrates on the Immune System in Individuals with Hemophilia. Transfus. Med. Rev. 6: 44–54. PubMed Google Scholar
Gordon, R.S., 1983. Factor VIII products and disordered immune regulation. Lancet i: 991. Google Scholar
Hardy, A.M., J.R. Allen, W.M. Morgan & J.W. Curran, 1985. The incidence rate of acquired immunodeficiency syndrome in selected populations. J. Am. Med. Assoc. 253: 215–220. Google Scholar
Hassett, J., G.F. Gjerset, J.W. Mosley, M.A. Fletcher, E. Donegan, J.W. Parker, R.B. Counts, L.M. Aledort, H. Lee, M.C. Pike & Transfusion Safety Study Group, 1993. Effect on Lymphocyte Subsets of Clotting Factor Therapy in Human Immunodeficiency Virus-1-Negative Congenital Clotting Disorders. Blood 82: 1351–1357. PubMed Google Scholar
Haverkos, H.W. & J.A. Dougherty, (eds), 1988. Health Hazards of Nitrite Inhalants. NIDA Research Monograph 83, US. Dept. Health & Human Services, Washington, DC. Google Scholar
Haverkos, H.W., P.F. Pinsky, D.P. Drotman & D.J. Bregman, 1985. Disease manifestation among homosexual men with acquired immunodeficiency syndrome: a possible role of nitrites in Kaposi's sarcoma. J. Sex. Trans. Dis. 12: 203–208. Google Scholar
Hilgartner, M.W., J.D. Buckley, E.A. Operskalski, M.C. Pike & J.W. Mosley, 1993. Purity of factor VIII concentrates and serial CD4 counts. Lancet 341: 1373–1374. PubMed Google Scholar
Hollan, S.R., G. Fuest, K. Nagy, A. Horvath, G. Krall, K. Verebelyi, E. Ujhelyi, L. Varga & V. Mayer, 1985. Immunological alterations in anti-HTLV-III negative haemophiliacs and homosexual men in Hungary. Immunol. Letters 11: 305–310. Google Scholar
Hughes, M.D., D.S. Stein, H.M. Gundacker, F.T. Valentine, J.P. Phair & P.A. Volberding, 1994. Within-Subject Variation in CD4 Lymphocyte Count in Asymptomatic Human Immunodeficiency Virus Infection: Implications for Patient Monitoring. The Journal of Infectious Diseases 169: 28–36. PubMed Google Scholar
Institute of Medicine, 1988. Confronting AIDS—Update 1988. National Academy Press, Washington, DC. Google Scholar
Institute of Medicine and National Academy of Sciences, 1986. Confronting AIDS. National Academy Press, Washington, DC. Google Scholar
Jason, J., R.C. Holman, B.L. Evatt & the Hemophilia-AIDS Collaborative Study Group, 1990. Relationship of partially purified factor concentrates to immune tests and AIDS. Am. J. Hematol. 34: 262–269. PubMed Google Scholar
Jason, J.M., J.S. McDougal, G. Dixon, D.N. Lawrence, M.S. Kennedy, M. Hilgartner, L. Aledort & B.L. Evatt, 1986. HTLV-III/LAV antibody and immune status of household contacts and sexual partners of persons with hemophilia. J. Am. Med. Assoc. 255: 212–215. Google Scholar
Jin, Z., R.P. Cleveland & D.B. Kaufman, 1989. Immunodeficiency in patients with hemophilia: an underlying deficiency and lack of correlation with factor replacement therapy or exposure to human immunodeficiency virus. Allergy Clin. Immunol. 83: 165–170. Google Scholar
Johnson, R.E., D.N. Lawrence, B.L. Evatt, D.J. Bregman, L.D. Zyla, J.W. Curran, L.M. Aledort, M.E. Eyster, A.P. Brownstein & C.J. Carman, 1985. Acquired immunodeficiency syndrome among patients attending hemophilia treatment centers and mortality experience of hemophiliacs in the United States. Am. J. Epidemiol. 121: 797–810. PubMed Google Scholar
Jones, C., 1994. AIDS: Words from the Front. SPIN, October: 7: 103–104. Google Scholar
Jones, P., S. Proctor, A. Dickinson & S. George, 1983. Altered immunology in haemophilia. Lancet i: 120–121. Google Scholar
Kessler, C.M., R.S. Schulof, A.L. Goldstein, P.H. Naylor, N.L. Luban, J.F. Kelleher & G.H. Reaman, 1983. Abnormal T-lymphocyte subpopulations associated with transfusions of blood-derived products. Lancet i: 991–992. Google Scholar
Koerper, M.A., 1989. AIDS and Hemophilia. In: AIDS: Pathogenesis and Treatment, pp. 79–95, J.A. Levy (ed.) Marcel Dekker, Inc., New York. Google Scholar
Kreiss, J.K., C.K. Kasper, J.L. Fahey, M. Weaver, B.R. Visscher, J.A. Steward & D.N. Lawrence, 1984. Nontransmission of T-cell subset abnormalities from hemophiliacs to their spouses. J. Am. Med. Assoc. 251: 1450–1454. Google Scholar
Kreiss, J.K., L.W. Kitchen, H.E. Prince, C.K. Kasper, A.L. Goldstein, P.H. Naylor, O. Preble, J.A. Stewart & M. Essex, 1986. Human T cell leukemia virus type III antibody, lymphadenopathy, and acquired immune deficiency syndrome in hemophiliac subjects. Am. J. Med. 80: 345–350. PubMed Google Scholar
Lang, D.J., A.A.S. Kovacs, J.A. Zaia, G. Doelkin, J.C. Niland, L. Aledort, S.P. Azen, M.A. Fletcher, J. Gauderman, G.J. Gjerst, J. Lusher, E.A. Operskalski, J.W. Parker, C. Pegelow, G.N. Vyas, J.W. Mosley & the Transfusion Safety Group, 1989. Seroepidemiologic studies of cytomegalovirus and Eptsein-Barr virus infections in relation to human immunodeficiency virus type 1 infection in selected recipient populations. J. AIDS 2: 540–549. Google Scholar
Lauritsen, J. & H. Wilson, 1986. Death, Rush, Poppers and AIDS. Pagan Press, New York. Google Scholar
Lawrence, D.N., J.M. Jason, R.C. Holman & J.J. Murphy, 1990. HIV transmission from hemophilic men to their heterosexual partners. In: Heterosexual Transmission of AIDS, pp. 35–53. N.J. Alexander, H.L. Gabelnick & Spieler, J.M. (eds.) Wiley-Liss, New York. Google Scholar
Lee, C.A., A.N. Phillips, J. Elford, G. Janossy, Janossy, P., Griffiths & P. Kernoff, 1991. Progressio of HIV disease in a haemophiliac cohort followed for 11 years and the effect of treatmen. Br. Med. J. 303: 1093–1096. Google Scholar
Lemp, G.F., S.F. Payne, G.W. Rutherford, N.A. Hessol, W. Winkelstein Jr., J.A. Wiley, A.R. Moss, R.E. Chaisson, R.T. Chen, D.W. Feigal, P.A. Thomas & Werdegar, D., 1990. Projections of AIDS morbidity and mortality in San Francisco. J. Am. Med. Assoc. 263: 1497–1501. Google Scholar
Lenderking, W.R., R.D. Gelber, D.J. Cotton, B.F. Cole, A. Goldhirsch, P.A. Volberuding & M.A. Testa, 1994. Evaluation of the quality of life associated with Zidovudine treatment in asymptomatic Human Immunodeficiency Virus Infection. N. Engl. J. Med. 330: 738–743. PubMed Google Scholar
Leonhard, H.-W., 1992. Alles nurein Irrtum? neue praxis: Zeitschrift für Sozialarbeit, Sozialpädogogik und Sozialpolitik 22: 14–29. Google Scholar
Lewis, A., 1994. Down the tabloid slope. New York Times, July, 4, Monday.
Ludlam, C.A., J. Tucker, C.M. Steel, R.S., Tedder, R. Cheingsong-Popov, R. Weiss, D.B.L. McClelland, I. Phillip & R.J. Prescott, 1985. Human T-lymphtropic virus type III (HTLV-III) infection in seronegative hemophiliacs after transfusion of factor VIII. Lancet ii: 233–236. Google Scholar
Lui, K.-J., W.W. Darrow & G.W. Rutherford III, 1988. A modelbased estimate of the mean incubation period for AIDS in homosexual men. Science 240: 1333–1335. PubMed Google Scholar
Lundgren, J.D., A.N. Philips, C. Pedersen, N. Clumeck, J.M. Gatell, A.M. Johnson, B. Ledergerber, S. Vella & J.O. Nielsen, 1994. Comparison of long-term prognosis of patients with AIDS treated and not treated with Zidovudine. J. Am. Med. Assoc. 271: 1088–1092. Google Scholar
Macilwain, C., 1994. AAAS criticized over AIDS sceptics' meeting. Nature (London) 369: 265. Google Scholar
Madhok, R., A. Gracie, G.D.O. Lowe, A. Burnett, K. Froebel, E. Follett & C.D. Forbes, 1986. Impaired cell mediated immunity in haemophilia in the absence of infection with human immunodeficiency virus. Br. Med. J. 293: 978–980. Google Scholar
Mahir, W.S., R.E. Millard, J.C. Booth & P.T. Flute, 1988. Functional studies of cell-mediated immunity in haemophilia and other bleeding disorders. Br. J. Haematol. 69: 367–370. PubMed Google Scholar
Mannucci, P.M., A. Gringeri, R. De Biasi, F. Baudo, M. Morfini & N. Ciavarella, 1992. Immune status of asymptomatic HIV-infected hemophiliacs: randomised, prospective, two-year comparison of treatment with a high-priority of an intermediate purity factor VIII concentrate. Thromb. Haemost. 67: 310–313. PubMed Google Scholar
Marmor, M., A.E. Friedman-Kien, L. Laubenstein, R.D. Byrum, D.C. William, S. D'Onofrio & N. Dubin, 1982. Risk factors for Kaposi's sarcoma in homosexual men. Lancet i: 1083–1087. Google Scholar
Matheson, D.S., B.J. Green, M.J. Fritzler, M.-C. Poon, T.J. Bowen & D.I. Hoar, 1987. Humoral immune response in patients with hemophilia. Clin. Immunol Immunopathol. 4: 41–50. Google Scholar
Mathur-Wagh, U., R.W. Enlow, I. Spigland, R.J. Winchester, H.S. Sacks, E. Rorat, S.R. Yancovitz, M.J. Klein, D.C. William & D. Mildwan, 1984. Longitudinal study of persistent generalized lyumphadenopathy in homosexual men: Relation to acquired immunodeficiency syndrom. Lancet i: 1033–1038. Google Scholar
Mathur-Wagh, U., D. Mildvan & R.T. Senie, 1985. Follow-up of 4 1/2 years on homosexual men with generalized lymphadenopathy. N. Engl. J. Med. 313: 1542–1543. PubMed Google Scholar
Maynard, T., 1994. Factor concentrate is a co-factor. Aids News (Hemophilia Council of California) 8: 1. Google Scholar
McGrady, G.A., J.M. Jason & B.L. Evatt, 1987. The course of the epidemic of acquired immunodeficiency syndrome in the United States hemophilia population. Am. J. Epidemiol. 126: 25–80. PubMed Google Scholar
Menitove, J.E., R.H. Aster, J.T. Casper, S.J. Lauer, J.L. Gottschall, J.E. Williams, J.C. Gill, D.V. Wheeler, V. Piaskowski, P. Kirchner & R.R. Montgomery, 1983. T-lymphocyte subpopulations in patients with classic hemophilia treated with cryoprecipitate and lyophilized concentrates. N. Engl. J. Med. 308: 83–86. PubMed Google Scholar
Merrian-Webster (eds), 1965 Webster's Third International Dictionary. G. & C. Merriam Co., Springfield, MA. Google Scholar
Moffat, E.H. & Bloom, A.L., 1985. HTLV-III antibody status and immunological abnormalities in haemophiliac patients. Lancet i: 935. Google Scholar
Morgan, M., J.W. Curran & R.L. Berkelman, 1990. The future course of AIDS in the United States. J. Am. Med. Assoc. 263: 1539–1540. Google Scholar
Newell, G.R., P.W.A. Mansell, M.B. Wilson, H.K. Lynch, M.R. Spitz & E.M. Hersh, 1985. Risk factor analysis among men referred for possible acquired immune deficiency syndrome. Preventive Med. 14: 81–91. Google Scholar
Mussbaum, B., 1990. Good Intentions: How Big Business, Politics, and Medicine are Corrupting the Fight Against AIDS. Atlantic Monthly Press, New York. Google Scholar
Oddone, E.Z., P. Cowper, J.D. Hamilton, D.B. Matchar, P. Hartigan, G. Samsa, M. Simberkoff & J.R. Feussner, 1993. Costeffectiveness analysis of early zidovudine treatment of HIV infected patients. Br. Med. J. 307: 1322–1325. Google Scholar
Oppenheimer, G.M. 1992. Causes, cases, and cohorts: The role of epidemiology in the historical construction of AIDS. In: AIDS: The Making of a Chronic Disease, pp. 49–83, E. Fee & D.M. Fox, (eds.) University of California Press, Berkeley. Google Scholar
Papadopulos-Eleopulos, E., V.F. Turner, J.M. Papdimitriou & D. Causer, 1994. Factor VIII, HIV and AIDS in haemophiliacs: an analysis of their relationship. Genetica in press.
Philips, A.N., C.A. Sabin, J. Elford, M. Bofill, V. Emery, P.D. Griffiths, G. Janossy & C.A. Lee, 1994a. Viral burden in HIV infection. Nature (London) 367: 124. Google Scholar
Phillips, A.N., C.A. Sabin, J. Elford, M. Bofill, G. Janossy & C.A. Lee, 1994b. Use of CD4 lymphocyte count to predict long term survival free of AIDS after HIV infection Br. Med. J. 309: 309–313. Google Scholar
Piatak, M., L.C. Saag, S.C. Yang, S.J. Clark, J.C. Kappes, K.-C. Luk, B.H. Hahn, G.M. Shaw & J.D. Lifson, 1993. High levelds of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science 259: 1749–1754. PubMed Google Scholar
Pollack, S., D. Atias, G. Yoffe, R. Katz, Y. Shechter & I. Tatarsky, 1985. Impaired immune function in hemophilia patients treated exclusively with cryoprecipitate: relation to duration of treatment. Am. J. Hematol 20: 1–6. PubMed Google Scholar
Prince, H., 1992. The significance of T lymphocytes in transfusion medicine. Transfus. Med. Rev. 16: 32–43. Google Scholar
Richman, D.D., M.A. Fischl, M.H. Grieco, M.S. Gottlieb, P.A. Volberding, O.L. Laskin, J.M. Leedom, J.E. Groopman, D. Mildvan, M.S. Hirsch, G.G. Jackson, D.T. Durack, S. Nusinoff-Lehrman & the AZT Collaborative Working Group 1987. The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. N. Engl. J. Med. 317: 192–197. PubMed Google Scholar
Schulman, S., 1991. Effects of factor VIII concentrates on the immune system in hemophilic patients. Annals of Hematology 63: 145–151. PubMed Google Scholar
Schwartlaender, B., O. Hamouda, M.A. Koch, W. Kiehl & C. Baars, 1992. AIDS/HIV 1991, AZ Hefte.
Schwarz, H.P., M. Kunschak, W. Engl & J. Eibl, 1994. High-purity Factor Concentrates in Prevention of AIDS. Lancet 343: 478–479. Google Scholar
Seligmann, M., D.A. Warrell, J.-P. Aboulker, C., Carbon, J.H. Darbyshire, J. Dormont, E. Eschwege, D.J. Girling, D.R. James, J.-P. Levy, P.T.A. Peto, D. Schwarz, A.B. Stone, I.V.D. Weller, R. Withnall, K. Gelmon, E. Lafon, A.M. Swart, V.R. Aber, A.G. Babiker, S. Lhoro, A.J. Nunn & M. Vray, 1994. Concorde: MCR/ANRS randomised double-blind controlled trial of immediate and deferred zidovudine in symptom-free HIV infection. Lancet 343: 871–881. PubMed Google Scholar
Selik, R.M., E.T. Starcher & J.W. Curran, 1987. Opportunistic diseases reported in AIDS patients: frequencies, associations, and trends. AIDS 1: 175–182. PubMed Google Scholar
Seremetis, S.V., L.M. Aledort, G.E. Bergman, R. Bona, G. Bray, D. Brettler, M.E. Eyster, C. Kessler, T.-S. Lau, J. Lusher & F. Rickles, 1993. Three-year randomised study of high-purity or intermediate-purity factor VIII concentrates in symptomfree HIV-seropositive haemophiliacs: effects on immune status. Lancet 342: 700–703. PubMed Google Scholar
Sharp, R.A., S.M. Morley, J.S. Beck & G.E.D. Urquhart, 1987. Unresponsiveness to skin testing with bacterial antigens in patients with haemophilia A not apparently infected with human immunodeficiency virus (HIV). J. Clin. Pathol 40: 849–852. PubMed Google Scholar
Sheppard, H.W., M.S. Ascher & J.F. Krowka, 1993. Viral burden and HIV disease. Nature (London) 364: 291–292. Google Scholar
Shilts, R., 1985. And the Band Played On. St. Martin's Press, New York. Google Scholar
Simmonds, P., P. Balfe, J.F. Peutherer, C.A. Ludlam, J.P. Bishop & A.J. Leigh-Brown, 1990. Human immunodeficiency virusinfected individuals contain provirus in small numbers of peripheral mononuclear cells at low copy numbers. J. Virol. 64: 864–872. PubMed Google Scholar
Simmonds, P., D. Beatson, R.J.G. Cuthbert, H. Watson, B. Reynolds, J.F. Peutherer, J.V. Parry, C.A. Ludlam & C.M. Steel, 1991. Determinants of HIV disease progression: six-year longitudinal study in the Edinburgh haemophilia/HIV cohort. Lancet 338: 1159–1163. PubMed Google Scholar
Smith, D.K., J.J. Neal, S.D. Holmberg & Centers for Disease Control Idiopathic CD4+T-lymphocytopenia Task Force, 1993. Unexplained opportunistic infections and CD4+T-lymphocytopenia without HIV infection. N. Engl. J. Med. 328: 373–379. PubMed Google Scholar
Stehr-Green, J.K., R.C. Holman, J.M. Jason & B.L. Evatt, 1988. Hemophilia-associated AIDS in the United States, 1981 to September 1987. Am. J. Public Health 78: 439–442. PubMed Google Scholar
Stehr-Green, J.K., J.M. Jason, B.L. Evatt & the Hemophilia-Associated AIDS Study Group 1989. Geographic variability of hemophilia-associated AIDS in the United States: effect of population characteristics. Am. J. Hematol. 32: 178–183. PubMed Google Scholar
Sullivan, J.L., F.E. Brewster, D.B. Brettler, A.D. Forsberg, S.H. Cheeseman, K.S. Byron, S.M. Baker, D.L. Willitts, R.A. Lew & P.H. Levine, 1986. Hemophiliac immunodeficiency: influence of exposure to factor VIII concentrate, LAV/HTLV-III, and herpesviruses. J. Pediatr. 108: 504–510. PubMed Google Scholar
Thomas Jr., C.A., K.B. Mullis & P.E. Johnson, 1994. What causes AIDS? Reason 26, June: 18–23. Google Scholar
Tokars, J.I., R. Marcus, D.H. Culver, C.A. Schable, P.S. McKibben, C.I. Bandea and D.M. Bell, 1993. Surveillance of HIV Infection and Zidovudine Use among Health Care Workers after Occupational Exposure to HIV-infected Blood. Ann. Intern. Med. 118: 913–919. PubMed Google Scholar
Tsoukas, C., F. Gervais, J. Shuster, P. Gold, M. O'Shaughnessy & M. Robert-Guroff, 1984. Association of HTLIV-III antibodies and cellular immune status of hemophiliacs. N. Engl. J. Med. 31: 1514–1515. Google Scholar
Volberding, P.A., S.W. Lagakos, M.A. Koch, C. Pettinelli, M.W. Myers, D.K. Booth, H.H. Balfour Jr., R.C. Reichman, J.A. Bartlett, M.S. Hirsch, R.L. Murphy, W.D. Hardy, R. Soeiro, M.A. Fischl, J.G. Bartlett, T.C., Merigan, N.E. Hyslop, D.D. Richman, F.T. Valentine, L. Corey & the AIDS Clinical Trial Group of the National Institute of Allergy and Infectious Disease, 1990. Zidovudine in asymptomatic human immunodeficiency virus infection: A controlled trial in persons with fewer than 500 CD4-positive cells percubic millimeter. N. Engl. J. Med. 322: 941–949. PubMed Google Scholar
Weiss, R., 1991. Provenance of HIV strains. Nature (London) 349: 374. Google Scholar
Weiss, R. & Jaffe, H., 1990. Duesberg, HIV and AIDS. Nature (London) 345: 659–660. Google Scholar
Weiss, R.A., 1993. How does HIV cause AIDS? Science 260: 1273–1279. PubMed Google Scholar
Wells, J., 1993. We have to question the so-called ‘facts’. Capital Gay, August 20th: 14–15. Google Scholar
World Health Organization, 1992a. Acquired Immunodeficiency Syndrome (AIDS)—Data as of 1 January 1992. World Health Organization, Geneva. Google Scholar
World Health Organization, 1992b. WHO-Report No. 32: AIDS Surveillance in Europe (Situation by 31 st December 1991). Worl Health Organization, Geneva. Google Scholar