Effect of mouse genotype on interferon production. I. Lines congenic at theIf-1 locus (original) (raw)

Abstract

The level of circulating Interferon induced in mice by Newcastle disease virus is controlled by a single codominant locus,If-1, with two alleles,If-1 l for low and_If-1_ h for high production. This locus is linked to the histocompatibility locus_H-28_. Of three C57BL/6By lines congenic for the BALB/cBy allele at_H-28_, two are carrying the BALB/cBy allele and one, the C57BL/6By allele at_If-1_. Thus, mouse strains that are genetically very similar but different in their production of NDV-induced circulating Interferon now are available.

Access this article

Log in via an institution

Subscribe and save

• Get 10 units per month
• Download Article/Chapter or eBook
• 1 Unit = 1 Article or 1 Chapter
• Cancel anytime Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

• Baney, D. W. Recombinant-inbred strains: An aid to finding identity, linkage, and function of histocompatibility and other genes.Transplantation 11: 325–327, 1971.
  PubMed Google Scholar
• De Maeyer, E. and De Maeyer-Guignard, J.: Gene with quantitative effect on ckculating interferon induced by Newcastle disease virus.J. Virol. 3: 506–512, 1969.
  PubMed Google Scholar
• De Maeyer, E. and De Maeyer-Guignard, J.: A gene with quantitative effect on circulating interferon. Further studies.Ann. N. Y. Acad. Sci. 173: 228–238, 1970.
  Google Scholar
• De Maeyer, E. and De Maeyer-Guignard, J., and Bailey, D. W.: Loci with quantitative effect on ckculating interferon.Mouse News Letter, 48: 39, 1973.
  Google Scholar
• De Maeyer, E. and De Maeyer-Guignard, J., Hall, W. T., and Bailey, D. W.: A locus affecting ckculating interferon levels induced by mouse mammary tumor virus.J. Gen. Virol. 23: 209–211, 1974b.
  PubMed Google Scholar
• De Maeyer, E., Mobraaten, L., and De Maeyer-Guignard, J.: Prolongation of allograft survival in mice by interferon inducers and interferon preparations.Gulbenkian Symposium on Interferon. Academic Press,in press 1974a.
• Martelly, I., Bailey, D. W., and De Maeyer-Guignard, J.; Poids moleculaires de l'interferon serique induit par les virus de la maladie de Newcastle dans des lignees de souris hautes et basses productrices.Ann. Inst. Pasteur 123: 835–848, 1972.
  Google Scholar
• Snell, D. G.: Methods for the study of histocompatibility genes.Genetics 49: 87–108, 1948.
  Google Scholar
• Steel, R. G. D. and Torrie, J. H.: In_Principles and Procedures of Statistics_, pp. 110–114, McGraw-Hill, New York, 1960.
  Google Scholar

Download references

Author information

Authors and Affiliations

1. Institut du Radium-Universite de Paris-Sud, 91405, Orsay, France
   E. De Maeyer & J. De Maeyer-Guignard
2. The Jackson Laboratory, 04609, Bar Harbor, Maine
   Donald W. Bailey

Authors

1. E. De Maeyer
   You can also search for this author inPubMed Google Scholar
2. J. De Maeyer-Guignard
   You can also search for this author inPubMed Google Scholar
3. Donald W. Bailey
   You can also search for this author inPubMed Google Scholar

Rights and permissions

About this article

Cite this article

De Maeyer, E., De Maeyer-Guignard, J. & Bailey, D.W. Effect of mouse genotype on interferon production. I. Lines congenic at the_If-1_ locus.Immunogenetics 1, 438–443 (1974). https://doi.org/10.1007/BF01564081

Download citation

• Received: 21 June 1974
• Issue Date: December 1974
• DOI: https://doi.org/10.1007/BF01564081

Keywords