A new serologically defined locus,Qa-1, in theTla-region of the mouse (original) (raw)

Abstract

A new cell-surface antigen, specified by a gene between_H-2D_ and_Tla_ is described. The provisional notation_Qa-1_ is suggested for the locus determining this newly recognized cell surface component. Qa-1 is distinguished from known TL antigens by the following two criteria. Its expression is not confined to thymocytes — it occurs on lymph node cells (LNC) also; and the phenotypes of the new congenic recombinant strains B6.K1 and B6.K2, derived from_H-2D/Tla_ crossovers, are Qa-1+ Qa-2−TL− and Qa-l+Qa-2+TL−. Qa-1 antigen is defined by reaction of the standard TL typing serum, (B6 × A -Tla b)F1 anti-A strain leukemia ASL1, with lymph node cells (LNC) in the cytotoxicity assay. Qa-1 antigen evidently is expressed, at least, on a subpopulation of T cells as well as on thymocytes. The gene order is_H-2D, Qa-1, Qa-2, Tla_.

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Abbreviations

LNC:

lymph node cells pooled from inguinal, axillary, brachial, and mesentric nodes

BA+:

(C57BL/6-TlaaxA)F1

BA−:

(C57BL/6 × A -Tla b)F1

PBS:

phosphate buffered saline pH 7.2

Thy:

thymocytes

RαMIg:

Rabbit anti-mouse immunoglobulin

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Authors and Affiliations

1. Memorial Sloan-Kettering Cancer Center, 10021, New York, New York
   Thomas H. Stanton & Edward A. Boyse

Authors

1. Thomas H. Stanton
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2. Edward A. Boyse
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Please address proofs and communications concerning this paper to Dr. Thomas Stanton, Sloan Kettering Institute, 1275 York Ave., New York, N.Y. 10021

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Stanton, T.H., Boyse, E.A. A new serologically defined locus,Qa-1, in the_Tla_-region of the mouse.Immunogenetics 3, 525–531 (1976). https://doi.org/10.1007/BF01576982

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• Received: 30 March 1976
• Revised: 24 May 1976
• Issue Date: December 1976
• DOI: https://doi.org/10.1007/BF01576982

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