Peptide nucleic acid (PNA): A model structure for the primordial genetic material? (original) (raw)
Article summary
AI generated
The origin of genetic material is a critical question in understanding the evolution of life, with traditional theories focusing on RNA as the precursor to DNA. This study proposes peptide nucleic acids (PNA) as a potential primordial genetic material, demonstrating that PNA can form stable duplexes and suggesting a PNA/RNA world where PNA serves as the genetic template for RNA, thereby expanding our understanding of the molecular foundations of life.
This is an AI-generated summary, check important information.
References
- Cherny, D. Y., Belotserkovskii, B. P., Frank-Kamenetskii, M. D., Egholm, M., Buchardt, O., Berg., R. H., and Nielsen, P. E.: 1993,Proc. Natl. Acad. Sci. USA 90, 1667–1670.
Google Scholar - Cech, T.: 1986,Proc. Natl. Acad, Sci. USA 83, 4360–4363.
Google Scholar - Cech, T.: 1987,Science 236, 1532–1539.
Google Scholar - Eschenmoser, A. and Lowenthal, E.: 1992,Chem. Soc. Rev. 21, 1–16.
Google Scholar - Egholm, M., Buchardt, O., Nielsen, P. E., and Berg, R.H.: 1992a,J. Amer. Chem. Soc. 114, 1895–1897.
Google Scholar - Egholm, M., Buchardt, O., Nielsen, P. E., and Berg, R. H.: 1992b,J. Amer. Chem. Soc. 114, 9677–9678.
Google Scholar - Egholm, M., Behrens, C, Christensen, L., Berg, R. H., Nielsen, P. E., and Buchardt, O.: 1993a,J. Chem. Soc. Chem. Commun., pp. 800–801.
- Egholm, M., Buchardt, O., Christensen, L., Behrens, C, Freier, S. M., Berg, R. H., Kim, S., Nordén, B., and Nielsen, P. E.: 1993b, submitted.
- Ferris, J. P.: 1987,CSH Symp. Quant. Biol. 52, 29–35.
Google Scholar - Gedulin, B. and Arrhenius, G.: 1992,Early Life on Earth. Nobel Symposium 84. Bengtson, S. (ed.), Columbia University Press (in press).
- Hyrup, B., Egholm, M., Berg, R. H., Nielsen, P. E., and Buchardt, O.: 1993,J. Chem. Soc. Chem. Commun., pp. 518–519.
- Joyce, G. F., Schwartz, A. W., Miller, S. L., and Orgel, L. E.: 1987,Proc. Natl. Acad. Sci. USA 84, 4398–4402.
Google Scholar - Lahaw, N., and White, D. H.: 1980,J. Mol. Evol 16, 11–21.
Google Scholar - Miller, S. L.: 1953,Science 117, 528–529.
Google Scholar - Miller, S. L.: 1987,CSH Symp. Quant. Biol. 52, 17–27.
Google Scholar - Nielsen, P. E., Egholm, M., Berg, R. H., and Buchardt, O.: 1991,Science 254, 1497–1500.
Google Scholar - Noller, H. F., Hoffarth, V., and Zimniak, L.: 1992,Science 256, 1416–1419.
Google Scholar - Orgel, L.: 1987,CSH Symp. Quant. Biol. 52, 9–16.
Google Scholar - Orgel, L.: 1992,Nature,358, 203–209.
Google Scholar - Oro, J.: 1960,Biochem. Biophy. Res. Commun. 2, 407–412.
Google Scholar - Watson, J. D. and Crick, F. H. C.: 1953,Nature 171, 964–967.
Google Scholar - Wong, J. T.-F: 1991,Origins Life Evol. Biosphere 21, 165–176.
Google Scholar