Specific inhibition of epidermal growth factor receptor tyrosine kinase by 4-anilinoquinazolines (original) (raw)
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References
- Sainsbury JRC, Malcolm AJ, Appleton DR, Farndon JR, Harris AL: Presence of epidermal growth factor receptor as an indicator of poor prognosis in patients with breast cancer. J Clin Pathol 38:1225–1228, 1985.
PubMed Google Scholar - Gullick WJ: Prevalence of aberrant expression of the epidermal growth factor receptor in human cancers. Br Med Bull 47:87–98, 1991.
Google Scholar - Rajkumar T, Gullick WJ: The Type I growth factor receptors in human breast cancer. Breast Cancer Res Treat 29:3–9, 1994.
PubMed Google Scholar - Yarden Y, Ullrich A: Growth factor receptor tyrosine kinases. Ann Rev Biochem 57:443–478, 1998.
Google Scholar - Schlessinger J: How receptor tyrosine kinases activate Ras. Trends Biochem Sci 18:273–275, 1993.
PubMed Google Scholar - Ennis BW, Lippman ME, Dickson RB: The EGF receptor system as a target for antitumor therapy. Cancer Investigation 9:553–562, 1991.
PubMed Google Scholar - Workman P: The potential for molecular oncology to define new drug targets.In Kerr DJ, Workman P (eds) New Molecular Targets for Cancer Chemotherapy. CRC Press, London, 1994, pp 1–29.
Google Scholar - Burke TR Jr: Protein-tyrosine kinase inhibitors. Drugs of the Future 17:119–131, 1992.
Google Scholar - Hanks SK: Eukaryotic protein kinases. Current Opin Struct Biol 1:369–383, 1991.
Google Scholar - Yaish P, Gazit A, Gilon C, Levitzki A: Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science 242:933–935, 1988.
PubMed Google Scholar - Ward WHJ, Cook PN, Slater AM, Davies DH, Holdgate GA, Green LR: Epidermal growth factor receptor tyrosine kinase. Investigation of catalytic mechanism, structure-based searching and discovery of a potent inhibitor. Biochem Pharmacol 48:659–666, 1994.
PubMed Google Scholar - Mosmann T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 56:55–63, 1983.
PubMed Google Scholar - Posner I, Engel M, Levitzki A: Kinetic model of the epidermal growth factor (EGF)-receptor tyrosine kinase and a possible mechanism of its activation by EGF. J Biol Chem 267:20638–20647, 1992.
PubMed Google Scholar - Levitzki A: Tyrphostins — potential antiproliferative agents and novel molecular tools. Biochem Pharmacol 40:913–918, 1990.
PubMed Google Scholar - Thompson AM, Rewcastle GW, Tercel M, Dobrusin EM, Fry DW, Kraker AJ, Denny WA: Tyrosine kinase inhibitors. 1. Structure-activity relationships for inhibition of epidermal growth factor receptor tyrosine kinase activity by 2,4-dihydro-2-thioxo-1_H_-indole-3-alkanoic acids and 2,2'-dithiobis(1_H_-indole-3-alkanoic acids). J Med Chem 36:2459–2469, 1993.
PubMed Google Scholar - Buchdunger E, Trinks U, Mett H, Regenass U, Muller M, Meyer T, McGlynn E, Pinna LA, Traxler P, Lydon NB: 4,5-dianilinophthalimide: a protein-tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent_in vivo_ antitumor activity. Proc Natl Acad Sci USA 91:2334–2338, 1994.
PubMed Google Scholar - Fry DW, Kraker AJ, McMichael A, Ambroso LA, Nelson JM, Leopold WR, Connors RW, Bridges AJ: A specific inhibitor of epidermal growth factor receptor tyrosine kinase. Science 265:1093–1095, 1994.
PubMed Google Scholar - Osherov N, Gazit A, Gilon C, Levitzki A: Selective inhibition of the epidermal growth factor and HER2/Neu receptors by tyrphostins. J Biol Chem 268: 11134–11142, 1993.
PubMed Google Scholar - Vignon F, Bouton M-M, Rochefort H: Antiestrogens inhibit the mitogenic effect of growth factors on breast cancer cells in the total absence of estrogens. Biochem Biophys Res Commun 146:1502–1508, 1987.
PubMed Google Scholar - Koga M, Sutherland RL: Epidermal growth factor partially reverses the inhibitory effects of antioestrogens on T47D human breast cancer cell growth. Biochem Biophys Res Commun 146:739–747, 1987.
PubMed Google Scholar - Wakeling AE, Newboult E, Peters SW: Effects of antioestrogens on the proliferation of MCF-7 human breast cancer cells. J Molec Endocr 2:225–234, 1989.
Google Scholar - Ignar-Trowbridge DM, Nelson KG, Bidwell MC, Curtis SW, Washburn TF, McLachlan JA, Korach KS: Coupling of dual signalling pathways: Epidermal growth factor action involves the estrogen receptor. Proc Natl Acad Sci USA 89:4658–4662, 1992.
PubMed Google Scholar - Newton CJ, Buric R, Trapp T, Brockmeier S, Pagotto U, Stalla GK: The unliganded estrogen receptor (ER) transduces growth factor signals. J Steroid Biochem Mol Biol 48:481–486, 1994.
PubMed Google Scholar - Reddy KB, Mangold GL, Tandon AK, Yoneda T, Mundy GR, Zilberstein A, Osborne CK: Inhibition of breast cancer cell growth_in vitro_ by a tyrosine kinase inhibitor. Cancer Res 52:3636–3641, 1992.
PubMed Google Scholar - Yoneda T, Lyall RM, Alsina MM, Persons PE, Spada AP, Levitzki A, Zilberstein A, Mundy GR: The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma_in vitro_ and in nude mice. Cancer Res 51:4430–4435, 1991.
PubMed Google Scholar