Effect of vasopressin on hepatocytic and ductal bile formation in the dog (original) (raw)

Zusammenfassung

In Studien an 8 cholecystektomierten, mit einerThomas-Kanüle versehenen, nicht-anaesthesierten Hunden konnte nach i.v. Injektion von 0,5 E pro kg Körpergewicht Lysin-8-Vasopressin eine Erhöhung des Gallenflusses um durchschnittlich 55% beobachtet werden. Da die biliäre Clearance von14C-Erythritol — ein Mass des canaliculären Gallenflusses — gleichzeitig anstieg, die Cholerese aber als Zusatz einer HCO3 —und Cl− reichen Flüssigkeit imponierte, scheint es wahrscheinlich, dass Vasopressin hepatocytäre und ductuläre Mechanismen der Gallenbildung beeinflusst.

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Authors and Affiliations

1. Department of Clinical Pharmacology, University of Berne, Friedbühlstr. 49, CH-3008, Bern, Switzerland
   R. Preisig, H. Strebel, G. Egger & V. Macarol

Authors

1. R. Preisig
2. H. Strebel
3. G. Egger
4. V. Macarol

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Preisig, R., Strebel, H., Egger, G. et al. Effect of vasopressin on hepatocytic and ductal bile formation in the dog.Experientia 28, 1436–1437 (1972). https://doi.org/10.1007/BF01957835

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• Published: 01 December 1972
• Issue date: December 1972
• DOI: https://doi.org/10.1007/BF01957835

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