Effect of meropenem on the intestinal microflora (original) (raw)

Abstract

Ten healthy volunteers were given 500 mg of meropenem by intravenous infusion over 30 min three times daily for seven days. Stool specimens were collected before, during and after meropenem administration. The numbers of enterobacteria and streptococci decreased during the administration period, while the numbers of enterococci increased. There was a decrease in the numbers of clostridia, bacteroides and gramnegative cocci, while the numbers of gram-positive cocci and rods were not changed by the administration of meropenem. The intestinal flora returned to normal in all volunteers within two weeks after the termination of meropenem administration.

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References

  1. Edwards JR, Turner PJ, Wannop C, Withnell ES, Grindey AJ, Nairn K: In vitro antibacterial activity of SM 7338, a carbapenem antibiotic with stability to dehydropeptidase I. Antimicrobial Agents and Chemotherapy 1989, 33: 215–222.
    PubMed Google Scholar
  2. Nord CE, Heimdahl A, Kager L: Antimicrobial induced alterations by the oropharyngeal and intestinal microflora. Scandinavian Journal of Infectious Diseases 1986, 49: 64–72.
    PubMed Google Scholar
  3. Nord CE: Studies on the ecological impact of antibiotics. European Journal of Clinical Microbiology and Infectious Diseases 1990, 9: 517–518.
    Google Scholar
  4. Heimdahl A, Nord CE: Effect of phenoxymethyl-penicillin and clindamycin on the oral, throat and faecal microflora of man. Scandinavian Journal of Infectious Diseases 1979, 11: 233–242.
    PubMed Google Scholar
  5. Nord CE: Ecological benefits on the use of narrow spectrum antimicrobial agents compared to broad spectrum antimicrobial agents. Spanish Journal of Chemotherapy 1989, 2: 223–226.
    Google Scholar

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Authors and Affiliations

  1. Department of Microbiology, Institute of Pharmacy, University of Oslo, Oslo, Norway
    T. Bergan
  2. Department of Microbiology, Aker Hospital, Oslo, Norway
    T. Bergan
  3. Department of Microbiology, Karolinska Institute, Huddinge University Hospital, S-141 86, Huddinge, Sweden
    C. E. Nord
  4. Department of Medicine, Landspitalinn, Reykjavik, Iceland
    S. B. Thorsteinsson

Authors

  1. T. Bergan
  2. C. E. Nord
  3. S. B. Thorsteinsson

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Bergan, T., Nord, C.E. & Thorsteinsson, S.B. Effect of meropenem on the intestinal microflora.Eur. J. Clin. Microbiol. Infect. Dis. 10, 524–527 (1991). https://doi.org/10.1007/BF01963943

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