Abolition of latent inhibition by a single 5 mg dose ofd-amphetamine in man (original) (raw)

Abstract

The performance of healthy volunteer subjects on an auditory latent inhibition (LI) paradigm was assessed following administration of a single oral dose of_d_-amphetamine or placebo. It was predicted that a low (5 mg), but not a high (10 mg), dose of_d_-amphetamine would disrupt LI. The prediction was supported with left ear presentation of the preexposed stimulus only. When the preexposed stimulus was presented to the right ear the predicted pattern of findings was not obtained. It is concluded that the dopaminergic system is involved in the mediation of LI in man and it is speculated that the interaction between amphetamine dose and ear of presentation of the preexposed stimulus may reflect normally occurring dopaminergic hemisphere asymmetry.

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Authors and Affiliations

1. Department of Psychology, Institute of Psychiatry, SE5 8AF, London, UK
   N. S. Gray, D. R. Hemsley & J. A. Gray
2. Department of Psychology, St. George's Hospital Medical School, SW17 ORE, London, UK
   A. D. Pickering
3. National Poisons Unit, Guy's and Lewisham Trust, Avonley Road, SE14 5ER, London, UK
   S. Dawling

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1. N. S. Gray
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2. A. D. Pickering
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3. D. R. Hemsley
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4. S. Dawling
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5. J. A. Gray
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Gray, N.S., Pickering, A.D., Hemsley, D.R. et al. Abolition of latent inhibition by a single 5 mg dose of_d_-amphetamine in man.Psychopharmacology 107, 425–430 (1992). https://doi.org/10.1007/BF02245170

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• Received: 17 July 1991
• Revised: 22 October 1991
• Issue Date: June 1992
• DOI: https://doi.org/10.1007/BF02245170

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