Cardiomyopathy associated with noninsulin-dependent diabetes (original) (raw)
Himsworth HP: Diabetes mellitus: Its differentiation into insulin-sensitive and insulin-insensitive types. Lancet 1: 117–120, 1936 Google Scholar
Weir GC, Leahy JL, Bonner-Weir S: Experimental reduction of β-cell mass: implication for the pathogenesis of diabetes. Diabetes Metabol Rev 2: 125–161, 1986 ArticleCAS Google Scholar
Lipson LG: Diabetes in the elderly. Diagnosis, pathogenesis and therapy. Am J Med 80 (Supp. 5A): 10–21, 1986 ArticlePubMedCAS Google Scholar
Wilson PWF, Anderson KM, Kannel WB: Epidemiology of diabetes mellitus in the elderly: The Framingham study. Am J Med 80 (Supp. 5B): 3–9, 1986 ArticlePubMedCAS Google Scholar
DeFronzo RA: The triumvirate: β-cell, muscle, liver: A collusion responsible for NIDDM. Diabetes 37: 667–687, 1988 PubMedCAS Google Scholar
Coleman DL: Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14: 141–148, 1978 ArticlePubMedCAS Google Scholar
Surwit RS, Feinglos MN, Livingston EG, Kuhn CM, McCubbin JA: Behavioral manipulation of the diabetic phenotype in ob/ob mice. Diabetes 33: 616–618, 1984 PubMedCAS Google Scholar
Kalderon B, Gutman A, Levy E, Shafrir E, Adler JH: Characterization of stages in development of obesity-diabetes syndrome in sand rat (Psammomys obesus). Diabetes 35: 717–724, 1986 PubMedCAS Google Scholar
Jeanrenaud B: Neuroendocrine and metabolic basis of type II diabetes as studied in animal models. Diabetes/Metabolism Reviews 4: 603–614, 1988 PubMedCAS Google Scholar
Slieker LJ, Roberts EF, Shaw WN, Johnson WT: Effect of streptozocin-induced diabetes on insulin-receptor tyrosine kinase activity in obese Zucker rats. Diabetes 39: 619–625, 1990 PubMedCAS Google Scholar
Weir GC, Clore ET, Zmachinski CJ, Bonner-Weir S: Islet secretion in a new experimental model for noninsulin-dependent diabetes. Diabetes 30: 590–595, 1981 PubMedCAS Google Scholar
Portha B, Picon L, Rosselin G: Chemical diabetes in the adult rat as the spontaneous evolution of neonatal diabetes. Diabetologia 17: 371–377, 1979 ArticlePubMedCAS Google Scholar
Portha B, Blondel O, Serradas P, McEvoy R, Giroix M-H, Kergoat M, Bailbe D: The rat models of non-insulin dependent diabetes induced by neonatal streptozotocin. Diabete & Metabolism 15: 61–75, 1989 CAS Google Scholar
Ward WK, Beard JE, Halter JB, Pfeifer MA, Porte D Jr: Pathophysiology of insulin secretion in non-insulin-dependent diabetes mellitus. Diabetes Care 7: 491–502, 1984 PubMedCAS Google Scholar
Steiner KE, Bowles CR, Mouton SM, Williams PE, Cherrington AD: The relative importance of first- and second-phase insulin secretion in countering the action of glucagon on glucose turnover in the conscious dog. Diabetes 31: 964–972, 1982 PubMedCAS Google Scholar
Giroix M-H, Portha B, Kergoat M, Bailbe D, Picon L: Glucose insensitivity and amino-acid hypersensitivity of insulin release in rats with non-insulin-dependent diabetes: A study with the perfused pancreas. Diabetes 32: 445–451, 1983 PubMedCAS Google Scholar
Blondel O, Bailbe D, Portha B: Relation of insulin deficiency to impaired insulin action in NIDDM adult rats given streptozocin as neonates. Diabetes 38: 610–617, 1989 PubMedCAS Google Scholar
Trent DF, Fletcher DJ, May JM, Bonner-Weir S, Weir GC: Abnormal islet and adipocyte function in young β-cell-deficient rats with near-normoglycemia. Diabetes 33: 170–175, 1984 PubMedCAS Google Scholar
Schaffer SW, Seyed-Mozaffari M, Cutcliff CR, Wilson GL: Postreceptor myocardial metabolic defect in a rat model of non-insulin-dependent diabetes mellitus. Diabetes 35: 593–597, 1986 PubMedCAS Google Scholar
Tahiliani AG, McNeill JH: Diabetes-induced abnormalities in the myocardium. Life Sci 38: 959–974, 1986 ArticlePubMedCAS Google Scholar
Crepaldi G, Nosadini R: Diabetic cardiopathy: Is it a real entity? Diabetes/Metabolism Reviews 4: 273–288, 1988 PubMedCAS Google Scholar
Regan TJ, Lyons MM, Ahmed SS, Levinson GE, Oldewurtel HA, Ahmed MR, Haider B: Evidence for cardiomyopathy in familial diabetes mellitus. J Clin Invest 60: 885–899, 1977 Google Scholar
Zoneraich S, Zoneraich O, Rhee JJ: Left ventricular performance in diabetic patients without clinical heart disease. Evaluation by systolic time intervals and echocardiography. Chest 72: 748–751, 1977 PubMedCAS Google Scholar
Uusitupa M, Siitonen O, Pyorala K, Lansimies E: Left ventricular function in newly diagnosed non-insulin-dependent (Type 2) diabetics evaluated by systolic time in tervals and echocardiography. Acta Med Scand 217: 379–388, 1985 ArticlePubMedCAS Google Scholar
Mustonen J, Laakso M, Uusitupa M, Sarlund H, Pyorala K, Rautio P, Kuikka J, Lansimies E: Improvement of left ventricular function after starting insulin treatment in patients with non-insulin-dependent diabetes. Diabetes Res 9: 27–30, 1988 PubMedCAS Google Scholar
Shapiro LM, Leatherdale BA, Coyne ME, Fletcher RF, Mackinnon J: Prospective study of heart disease in untreated maturity onset diabetes. Br Heart J 44: 342–348, 1980 PubMedCAS Google Scholar
Pozzoli G, Vitolo E, Collini P, DeMaria R, Castelli MR, Colombo F: Assessment of left ventricular function with M-mode echocardiography in a selected group of diabetic patients. Acta Diabet Lat 21: 71–84, 1984 CAS Google Scholar
Uusitupa M, Mustonen J, Laakso M, Vainio P, Lansimies E, Talwar S, Pyorala K: Impairment of diastolic function in middle-aged Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetic patients free of cardiovascular disease. Diabetologia 31: 783–791, 1988 ArticlePubMedCAS Google Scholar
Stone PH, Muller JE, Hartwell T, York BJ, Rutherford JD, Parker CB, Turi ZG, Strauss HW, Willerson JT, Robertson T, Braunwald E, Jaffe AS: The effect of diabetes mellitus on prognosis and serial left ventricular function after acute myocardial infarction: Contribution of both coronary disease and diastolic left ventricular dysfunction to the adverse prognosis. J Am Coll Cardiol 14: 49–57, 1989 ArticlePubMedCAS Google Scholar
Randle PJ, Garland PB, Hales CN, Newsholme EA, Denton RM, Pogson CI: Interactions of metabolism and the physiological role of insulin. Rec Prog Hormone Res 22: 1–44, 1966 CAS Google Scholar
Wieland O, Siess E, Schulze-Wethmar FH, v. Funcke HG, Winton B: Active and inactive forms of pyruvate dehydrogenase in rat heart and kidney: Effect of diabetes, fasting and refeeding on pyruvate dehydrogenase interconversion. Arch Biochem Biophys 143: 593–601, 1971 ArticlePubMedCAS Google Scholar
Sale GJ, Randle PJ: Incorporation of [32P] Phosphate into the pyruvate dehydrogenase complex in rat heart mitochondria. Biochem J 188: 409–421, 1980 PubMedCAS Google Scholar
Kerbey AL, Randle PJ: Thermolabile factor accelerates pyruvate dehydrogenase kinase reaction in heart mitochondria of starved or alloxan-diabetic rats. FEBS Lett. 127: 188–192, 1981 ArticlePubMedCAS Google Scholar
Kobayashi K, Neely JR: Effects of increased cardiac work on pyruvate dehydrogenase activity in hearts from diabetis animals. J Mol Cell Cardiol 15: 347–357, 1983 ArticlePubMedCAS Google Scholar
Kerbey AL, Randle PJ, Kearns A: Dephosphorylation of pig heart pyruvate dehydrogenase phosphate complexes by pig heart pyruvate dehydrogenase phosphate phosphatase. Biochem J 195: 51–59, 1981 PubMedCAS Google Scholar
Teague WM, Pettit FH, Yeaman SJ, Reed LJ: Function of phosphorylation sites on pyruvate dehydrogenase. Biochem Biophys Res Commun 87: 244–252, 1979 ArticlePubMedCAS Google Scholar
Dennis SC, Padma A, DeBuysere MS, Olson MS: Studies on the regulation of pyruvate dehydrogenase in the isolated perfused rat heart. J Biol Chem 254: 1252–1258, 1979 PubMedCAS Google Scholar
Olson MS, Dennis SC, DeBuysere MS, Padma A: The regulation of pyruvate dehydrogenase in the isolated perfused rat heart. J Biol Chem 253: 7369–7375, 1978 PubMedCAS Google Scholar
Latipaa PM, Peuhkurinen KJ, Hiltunen JK, Hassinen IE: Regulation of pyruvate dehydrogenase during infusion of fatty acids of varying chain lengths in the perfused rat heart. J Mol Cell Cardiol 17: 1161–1171, 1985 PubMedCAS Google Scholar
Bunger R, Permanetter B: Parallel stimulation by Ca2+ of inotropism and pyruvate dehydrogenase in perfused heart. Am J Physiol 247: C45-C52, 1984 PubMedCAS Google Scholar
Kobayashi K, Neely JR: Mechanism of pyruvate dehydrogenase activation by increased cardiac work. J Mol Cell Cardiol 15: 369–382, 1983 ArticlePubMedCAS Google Scholar
Kerbey AL, Randle PJ, Cooper RH, Whitehouse S, Pask HT, Denton RM: Regulation of pyruvate dehydrogenase in rat heart. Biochem J 154: 327–348, 1976 PubMedCAS Google Scholar
Randle PJ, Kerbey AL, Espinal J: Mechanisms decreasing glucose oxidation in diabetes and starvation: Role of lipid fuels and hormones. Diabetes/Metabolism Reviews 4: 623–638, 1988 PubMedCAS Google Scholar
Sale GJ, Randle PJ: Occupancy of phosphorylation sites in pyruvate dehydrogenase phosphate complex in rat heart_in vivo_. Biochem J 206: 221–229, 1982 PubMedCAS Google Scholar
Paulson DJ, Crass MF III: Endogenous triacylglycerol metabolism in diabetic heart. Am J Physiol 242: H1084-H1094, 1982 PubMedCAS Google Scholar
Caterson ID, Williams PF, Kerbey AL, Astbury LD, Plehwe WE, Turtle JR: The effect of body weight and the fatty acid-oxidation inhibitor 2-tetradecylglycidic acid on pyruvate dehydrogenase complex activity in mouse heart. Biochem J 224: 787–791, 1984 PubMedCAS Google Scholar
Caterson ID, Kerbey AL, Cooney GJ, Frankland R, Denyer GS, Nicks J, Williams PF: Inactivation of pyruvate dehydrogenase complex in heart muscle mitochondria of gold-thioglucose-induced obese mice is not due to a stable increase in activity of pyruvate dehydrogenase kinase. Biochem J 253: 291–294, 1988 PubMedCAS Google Scholar
Bell GI, Kayano T, Buse JB, Burant CF, Takeda J, Lin D, Fukumoto H, Seino S: Molecular biology of mammalian glucose transporters. Diabetes Care 13: 198–208, 1990 PubMedCAS Google Scholar
Kasanicki MA, Pilch PF: Regulation of glucose-transporter function. Diabetes Care 13: 219–227, 1990 PubMedCAS Google Scholar
James DE, Brown R, Navarro J, Pilch PF: Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein. Nature 333: 183–185, 1988 ArticlePubMedCAS Google Scholar
Joost HG, Weber TM: The regulation of glucose transport in insulin-sensitive cells. Diabetologia 32: 831–838, 1989 ArticlePubMedCAS Google Scholar
Klip A, Paquet MR: Glucose transport and glucose transporters in muscle and their metabolic regulation. Diabetes Care 13: 228–243, 1990 PubMedCAS Google Scholar
Thorens B, Charron MJ, Lodish HF: Molecular physiology of glucose transporters. Diabetes Care 13: 209–218, 1990 PubMedCAS Google Scholar
Kahn BB, Charron MJ, Lodish HF, Cushman SW, Flier JS: Differential regulation of two glucose transporters in adipose cells from diabetic and insulin-treated diabetic rats. J Clin Invest 84: 404–411, 1989 PubMedCAS Google Scholar
Kuo TH, Moore KH, Giacomelli F, Wiener J: Defective oxidative metabolism of heart mitochondria from genetically diabetic mice. Diabetes 32: 781–787, 1983 PubMedCAS Google Scholar
Safer B, Williamson JR: Mitochondrial-cytosolic interactions in perfused rat heart: Role of coupled transamination in repletion of citric acid cycle intermediates. J Biol Chem 248: 2570–2579, 1973 PubMedCAS Google Scholar
Schaffer SW, Tan BH, Wilson GL: Development of a cardiomyopathy in a model of noninsulin-dependent diabetes. Am J Physiol 248: H179-H185, 1985 PubMedCAS Google Scholar
Schaffer SW, Mozaffari MS, Artman M, Wilson GL: Basis for myocardial mechanical defects associated with noninsulin-dependent diabetes. Am J Physiol 256: E25-E30, 1989 PubMedCAS Google Scholar
Penpargkul S, Schaible T, Scheuer J: The effect of diabetes on performance and metabolism of rat hearts. Circ Res 47: 911–921, 1980 PubMedCAS Google Scholar
Litwin SE, Raya TE, Anderson PG, Daugherty S, Goldman S: Abnormal cardiac function in the streptozotocin-diabetic rat: Changes in active and passive properties of the left ventricle. J Clin Invest 86: 481–488, 1990 PubMedCAS Google Scholar
Regan TJ, Lyons MM, Ahmed SS, Levinson GE, Oldewurtel HA, Ahmed MR, Haider B: Evidence for cardiomyopathy in familial diabetes mellitus. J Clin Invest 60: 885–899, 1977 Article Google Scholar
Cobbold PH, Rink TJ: Fluorescence and bioluminescence measurement of cytoplasmic free calcium. Biochem J 248: 313–328, 1987 PubMedCAS Google Scholar
Dhalla NS, Pierce GN, Panagia V, Singal PK, Beamish RE: Calcium movements in relation to heart function. Basic Res Cardiol 77: 117–139, 1982 ArticlePubMedCAS Google Scholar
Langer GA, Frank JS, Philipson KD: Ultrastructure and calcium exchange of the sarcolemma, sarcoplasmic reticulum and mitochondria of the myocardium. Pharmacol Ther 6: 331–376, 1982 Article Google Scholar
Wier WG: Cytoplasmic [Ca2+] in mammalian ventricle: Dynamic control by cellular processes. Ann Rev Physiol 52: 467–485, 1990 ArticleCAS Google Scholar
Mullins LJ: The generation of electric currents in cardiac fibers by Na/Ca exchange. Am J Physiol 236: C103-C110, 1979 PubMedCAS Google Scholar
Makino N, Dhalla KS, Elimban V, Dhalla NS: Sarcolemmal Ca2+ transport in streptozotocin-induced diabetic cardiomyopathy in rats. Am J Physiol 253: E202-E207, 1987 PubMedCAS Google Scholar
Ganguly PK, Pierce GN, Dhalla KS, Dhalla NS: Defective sarcoplasmic reticular calcium transport in diabetic cardiomyopathy. Am J Physiol 244: E528-E535, 1983 PubMedCAS Google Scholar
Lopaschuk GD, Tahiliani AG, Vadlamudi RVSV, Katz S, McNeill JH: Cardiac sarcoplasmic reticulum function in insulin- or carnitine-treated diabetic rats. Am J Physiol 245: H969-H976, 1983 PubMedCAS Google Scholar
Heyliger CE, Prakash A, McNeill JH: Alterations in cardiac sarcolemmal Ca2+ pump activity during diabetes mellitus. Am J Physiol 252: H540-H544, 1987 PubMedCAS Google Scholar
Sperelakis N: Regulation of calcium slow channels of cardiac muscle by cyclic nucleotides and phosphorylation. J Mol Cell Cardiol 20 (Supp. II): 75–105, 1988 ArticlePubMedCAS Google Scholar
Tsien RW, Bean BP, Hess P, Lansman JB, Nilius B, Nowycky MC: Mechanisms of calcium channel modulation by β-adrenergic agents and dihydropyridine calcium agonists. J Mol Cell Cardiol 18: 691–710, 1986 PubMedCAS Google Scholar
Hescheler J, Kameyama M, Trautwein W, Mieskes G, Soling H-D: Regulation of the cardiac calcium channel by protein phosphatases. Eur J Biochem 165: 261–266, 1987 ArticlePubMedCAS Google Scholar
Allo SN, Schaffer SW: Defective sarcolemmal phosphorylation associated with noninsulin-dependent diabetes. Biochim Biophys Acta 1023: 206–212, 1990 ArticlePubMedCAS Google Scholar
Imagawa T, Leung AT, Campbell KP: Phosphorylation of the 1,4-dihydropyridine receptor of the voltage-dependent Ca2+ channel by an intrinsic protein kinase in isolated triads from rabbit skeletal muscle. J Biol Chem 262: 8333–8339, 1987 PubMedCAS Google Scholar
Nobe S, Aomine M, Arita M, Ito S, Takaki R: Chronic diabetes mellitus prolongs action potential duration of rat ventricular muscles: Circumstantial evidence for impaired Ca2+ channel. Cardiovasc Res 24: 381–389, 1990 ArticlePubMedCAS Google Scholar
Alpert NR, Mulieri LA: Functional consequences of altered cardiac myosin isoenzymes. Med Sci Sports Exerc 18: 309–313, 1986 PubMedCAS Google Scholar
Hoh JFY, McGrath PA, Hale PT: Electrophoretic analysis of multiple forms of rat cardiac myosin: Effects of hypophysectomy and thyroxine replacement. J Mol Cell Cardiol 10: 1053–1076, 1977 Article Google Scholar
Malhotra A, Karell M, Scheuer J: Multiple cardiac contractile protein abnormalities in myopathic Syrian hamsters (Bio 53:58). J Mol Cell Cardiol 17: 95–107, 1985 PubMedCAS Google Scholar
Wikman-Coffelt J, Sievers R, Parmley WW: Influence of myocardial isomyosins on cardiac performance and oxygen consumption. Biochem Biophys Res Commun 130: 1314–1323, 1985 ArticlePubMedCAS Google Scholar
Horowitz M, Peyser YM, Muhlrad A: Alterations in cardiac myosin isoenzymes distribution as an adaptation to chronic environmental heat stress in the rat. J Mol Cell Cardiol 18: 511–515, 1986 PubMedCAS Google Scholar
Takeda N, Ohkubo T, Hatanaka T, Takeda A, Nakamura I, Nagano M: Myocardial contractility and left ventricular myosin isoenzyme pattern in cardiac hypertrophy due to chronic volume overload. Basic Res Cardiol 82 (Supp. 2): 215–221, 1987 PubMed Google Scholar
Lecarpentier Y, Vugaisky LB, Chemla D, Mercadier JJ, Schwartz K, Whalen RG, Martin JL: Coordinated changes in contractility, energetics, and isomyosins after aortic stenosis. Am J Physiol 252: H275-H282, 1987 PubMedCAS Google Scholar
Malhotra A, Penpargkul S, Fein FS, Sonnenblick EH, Scheuer J: The effect of streptozotocin-induced diabetes in rats on cardiac contractile proteins. Circ Res 49: 1243–1250, 1981 PubMedCAS Google Scholar
Dillmann WH: Influence of thyroid hormone administration on myosin ATPase activity and myosin isoenzyme distribution in the heart of diabetic rats. Metabolism 31: 199–204, 1982 ArticlePubMedCAS Google Scholar
Garber DW, Everett AW, Neely JR: Cardiac function and myosin ATPase in diabetic rats treated with insulin, T3 and T4. Am J Physiol 244: H592-H598, 1983 PubMedCAS Google Scholar
Pollack PS, Malhotra A, Fein FS, Scheuer J: Effects of diabetes on cardiac contractile proteins in rabbits and reversal with insulin. Am J Physiol 251: H448-H454, 1986 PubMedCAS Google Scholar
Mozaffari MS, Allo S, Schaffer SW: The effect of sulfonylurea therapy on defective calcium movement associated with diabetic cardiomyopathy. Can J Physiol Pharmacol 67: 1431–1436, 1989 PubMedCAS Google Scholar
Dillmann WH: Fructose feeding increases Ca2+-activated myosin ATPase activity and changes myosin isoenzyme distribution in the diabetic rat heart. Endocrinology 114: 1678–1685, 1984 ArticlePubMedCAS Google Scholar
Dillmann WH: Methyl palmoxirate increases Ca2+-myosin ATPase activity and changes myosin isoenzyme distribution in the diabetic rat heart. Am J Physiol 248: E602-E606, 1985 PubMedCAS Google Scholar
Dillmann WH: Myosin isoenzyme distribution and Ca2+-activated myosin ATPase activity in the rat heart is influenced by fructose feeding and triiodothyronine. Endocrinology 116: 2160–2166, 1985 PubMedCAS Google Scholar
Paulson DJ, Kopp SJ, Peace DG, Tow JP: Myocardial adaptation to endurance exercise training in diabetic rats. Am J Physiol 252: R1073-R1081, 1987 PubMedCAS Google Scholar
Takeda N, Nakamura I, Ohkubo T, Hatanaka T, Nagano M: Effects of physical training on the myocardium of streptozotocin-induced diabetic rats. Bas Res Cardiol 83: 525–530, 1988 ArticleCAS Google Scholar
Fein FS, Malhotra A, Miller-Green B, Scheuer J, Sonnenblick EH: Diabetic cardiomyopathy in rats: Mechanical and chemical response to different insulin doses. Am J Physiol 247: H817-H823, 1984 PubMedCAS Google Scholar
Tahiliani AG, McNeill JH: Effects of triiodothyronine and carnitine therapy on myocardial dysfunction in diabetic rats. Can J Physiol Pharmacol 64: 669–672, 1986 PubMedCAS Google Scholar
Xiang H, Heyliger CE, McNeill JH: Effect of myo-inositol and T3 on myocardial lipids and cardiac function in streptozocin-induced diabetic rats. Diabetes 37: 1542–1548, 1988 PubMedCAS Google Scholar
Uusitupa M, Siitonen O, Aro A, Korhoer T, Pyorala K: Effect of correction of hyperglycemia on left ventricular function in non-insulin-dependent (type 2) diabetics. Acta Med Scand 213: 363–368, 1983 ArticlePubMedCAS Google Scholar
Kador PF, Kinoshita JH: Role of aldose reductase in the development of diabetes-associated complications. Am J Med 79 (Supp. 5A): 8–12, 1985 ArticlePubMedCAS Google Scholar
Fagius J, Brattberg A, Jameson S, Berne C: Limited benefit of treatment of diabetic polyneuropathy with an aldose reductase inhibitor: A 24 week controlled trial. Diabetologia 28: 323–329, 1985 ArticlePubMedCAS Google Scholar
Beyer-Mears A: The polyol pathway, sorbinil and renal dysfunction. Metabolism 35 (Supp. 1): 46–54, 1986 ArticlePubMedCAS Google Scholar
Engerman RL, Kern TS: Hyperglycemia as a cause of diabetic retinopathy. Metabolism 35 (Supp. 1): 20–23, 1986 ArticlePubMedCAS Google Scholar
Pfeifer MA: Clinical trials of sorbinil on nerve function. Metabolism 35 (Supp. 1): 78–82, 1986 ArticlePubMedCAS Google Scholar
Kador PF: The role of aldose reductase in the development of diabetic complications. Med Res Rev 8: 325–352, 1988 PubMedCAS Google Scholar
Bank N, Mower P, Aynedjian HS, Wilkes BM, Silverman S: Sorbinil prevent glomerular hyperfusion in diabetic rats. Am J Physiol 256: 171000–171006, 1989 Google Scholar
Roy TM, Broadstone VL, Peterson HR, Snider HL, Cyrus J, Fell R, Rothchild AH, Samols E, Pfeifer MA: The effect of an aldose reductase inhibitor on cardiovascular performance in patients with diabetes mellitus. Diabetes Res Clin Practice 10: 91–97, 1990 ArticleCAS Google Scholar
Cameron NE, Cotter MA, Robertson S: Contractile properties of cardiac papillary muscle in streptozotocin-diabetic rats and the effects of aldose reductase inhibition. Diabetologia 32: 365–370, 1989 ArticlePubMedCAS Google Scholar
Greene DA, Lattimer SA, Sima AAF: Sorbitol, phosphoinositides and sodium-potassium ATPase in the pathogenesis of diabetic complications. New Eng J Med 316: 599–606, 1987 ArticlePubMedCAS Google Scholar
Greene DA, Lattimer SA, Sima AAF: Are disturbances of sorbitol, phosphoinositide, and Na+-K+-ATPase regulation involved in pathogenesis of diabetic neuropathy? Diabetes 37: 688–693, 1988 PubMedCAS Google Scholar
Berge C-H, Hjalmarson A, Sjogren K-G, Jacobsson B: The effect of diabetes on phosphatidylinositol turnover and calcium influx in myocardium. Horm Metabol Res 20: 381–386, 1988 Google Scholar
Farese RV, Cooper DR: Potential role of phospholipid-signaling systems in insulin action and states of clinical insulin resistance. Diabetes/Metabolism Rev 5: 455–474, 1989 ArticleCAS Google Scholar
Kennedy L, Baynes JW: Non-enzymatic glycosylation and the chronic complications of diabetes: An overview. Diabetologia 26: 93–98, 1984 ArticlePubMedCAS Google Scholar
Kirschenbaum DM: Glycosylation of proteins: Its implications in diabetic control and complications. Ped Clinics North America 31: 611–621, 1984 CAS Google Scholar
Brownlee M, Cerami A, Vlassara H: Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. New Eng J Med 318: 1315–1321, 1988 ArticlePubMedCAS Google Scholar
Brownlee M, Cerami A: The biochemistry of the complications of diabetes mellitus. Ann Rev Biochem 50: 385–432, 1981 ArticlePubMedCAS Google Scholar
Ganguly PK, Thliveris JA, Mehta A: Evidence against the involvement of nonenzymatic glycosylation in diabetic cardiomyopathy. Metabolism 39: 769–773, 1990 ArticlePubMedCAS Google Scholar
Serrano MA, Cabezas JA, Reglero A: Carbohydrate contents and glycosidase and glycosyl transferase activities in tissues from streptozotocin diabetic mice. Comp Biochem Physiol 80: 629–632, 1985 ArticleCAS Google Scholar
Feuvray D, Idell-Wenger JA, Neely JR: Effects of ischemia on rat myocardial function and metabolism in diabetes. Circ Res 44: 322–329, 1979 PubMedCAS Google Scholar
Katz AM, Messineo FC: Lipid-membrane interactions and the pathogenesis of ischemic damage in the myocardium. Circ Res 48: 1–16, 1981 PubMedCAS Google Scholar
Corr PB, Gross RW, Sobel BE: Amphipathic metabolites and membrane dysfunction in ischemic myocardium. Circ Res 55: 135–154, 1984 PubMedCAS Google Scholar
Lopaschuk GD, Katz S, McNeill JH: The effect of alloxan- and streptozotocin-induced diabetes on calcium transport in rat cardiac sarcoplasmic reticulum. The possible involvement of long chain acylcarnitines. Can J Physiol Pharmacol 61: 439–448, 1983 PubMedCAS Google Scholar
Holman RT, Johnson SB, Gerrard JM, Mauer SM, Kupcho-Sandberg S, Brown DM: Arachidonic acid deficiency in streptozotocin-induced diabetes. Proc Natl Acad Sci USA 80: 2375–2379, 1983 ArticlePubMedCAS Google Scholar
Gudbjarnason S, El-Hage AN, Whitehurst VE, Simental F, Balazs T: Reduced arachidonic acid levels in major phospholipids of heart muscle in the diabetic rat. J Mol Cell Cardiol 19: 1141–1146, 1987 PubMedCAS Google Scholar
Horrobin DF: The roles of essential fatty acids in the development of diabetic neuropathy and other complications of diabetes mellitus. Prostaglandins Leukotr Ess Fatty Acids 31: 181–197, 1988 CAS Google Scholar
Black SC, Katz S, McNeill JH: Cardiac performance and plasma lipids of omega-3 fatty acid-treated streptozocininduced diabetic rats. Diabetes 38: 969–974, 1989 PubMedCAS Google Scholar
Brenner RR: Effect of unsaturated fatty acids in membrane structure and enzyme kinetics. Prog Lipid Res 23: 69–96, 1984 ArticlePubMedCAS Google Scholar
Stubbs CD, Smith AD: The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function. Biochim Biophys Acta 779: 89–137, 1984 PubMedCAS Google Scholar
Ganguly PK, Rice KM, Panagia V, Dhalla NS: Sarcolemmal phosphatidylethanolamine N-methylation in diabetic cardiomyopathy. Circ Res 55: 504–512, 1984 PubMedCAS Google Scholar
Gupta MP, Panagia V, Dhalla NS: Phospholipid N-methylation-dependent alterations of cardiac contractile function by L-methionine. J Pharmacol Exp Therap 245: 664–672, 1988 CAS Google Scholar
Wohaieb SA, Godin DV: Alterations in tissue antioxidant systems in the spontaneously diabetic (BB Wistar) rat. Can J Physiol Pharmacol 65: 2191–2195, 1987 PubMedCAS Google Scholar
Wohaieb SA, Godin DV: Alterations in free radical tissue-defense mechanisms in streptozocin-induced diabetes in rat: effects on insulin treatment. Diabetes 36: 1014–1018, 1987 PubMedCAS Google Scholar
Matkovics B, Varga SI, Szabo L, Witas H: The effect of diabetes on the activities of the peroxide metabolism enzymes. Horm Metabol Res 14: 77–79, 1982 ArticleCAS Google Scholar
Ganguly PK, Dhalla KS, Innes IR, Beamish RE, Dhalla NS: Altered norepinephrine turnover and metabolism in diabetic cardiomyopathy. Circ Res 59: 684–693, 1986 PubMedCAS Google Scholar
Pieper GM: Arachidonic acid causes postischemic dysfunction in control but not diabetic hearts. Am J Physiol 258: H923-H930, 1990 PubMedCAS Google Scholar
Zick Y: The insulin receptor: Structure and function. Critical Rev Biochem Mol Biol 24: 217–269, 1989 CAS Google Scholar
Van de Werve G, Zaninetti D, Lang U, Vallotton MB, Jeanrenaud B: Identification of a major defect in insulin-resistant tissues of genetically obese (fa/fa) rats: Impaired protein kinase C. Diabetes 36: 310–314, 1987 PubMed Google Scholar
Okumura K, Akiyama N, Hashimoto H, Ogawa K, Satake T: Alteration of 1,2-diacylglycerol content in myocardium from diabetic rats. Diabetes 37: 1168–1172, 1988 PubMedCAS Google Scholar
Yuan S, Sunahara FA, Sen AK: Tumor-promoting phorbol esters inhibit cardiac functions and induce redistribution of protein kinase C in perfused beating rat heart. Circ Res 61: 372–378, 1987 PubMedCAS Google Scholar
Keely SL, Corbin JD, Park CR: Regulation of adenosine 3′:5′-monophosphate-dependent protein kinase: Regulation of the heart enzyme by epinephrine, glucagon, insulin and 1-methyl-3-isobutylxanthine. J Biol Chem 250: 4832–4840, 1975 PubMedCAS Google Scholar
Miller TB Jr: Phosphorylase activation hypersensitivity in hearts of diabetic rats. Am J Physiol 246: E134-E140, 1984 PubMedCAS Google Scholar
Ingebritsen TS, Stewart AA, Cohen P: The protein phosphatases involved in cellular regulation: 6. Measurement of type-1 and type-2 protein phosphatases in extracts of mammalian tissues; an assessment of their physiological roles. Eur J Biochem 132: 297–307, 1983 ArticlePubMedCAS Google Scholar
Miller TB Jr: A dual role for insulin in the regulation of cardiac glycogen synthase. J Biol Chem 253: 5389–5394, 1978 PubMedCAS Google Scholar
Mumby M, Russell KL, Garrard LJ, Green DD: Cardiac contractile protein phosphatases: Purification of two enzyme forms and their characterization with subunit-specific antibodies. J Biol Chem 262: 6257–6265, 1987 PubMedCAS Google Scholar
Chisholm AAK, Cohen P: The myosin-bound form of protein phosphatase 1 (PP-1M) is the enzyme that dephosphorylates native myosin in skeletal and cardiac muscles. Biochim Biophys Acta 971: 163–169, 1988 ArticlePubMedCAS Google Scholar
Iyer RB, Koritz SB, Kirchberger MA: A regulation of the level of phosphorylated phospholamban by inhibitor-1 in rat heart preparations_in vivo_. Mol Cell Endocrinol 55: 1–6, 1988 ArticlePubMedCAS Google Scholar
Kranias EG, Steenaart NAE, DiSalvo J: Purification and characterization of phospholamban phosphatase from cardiac muscle. J Biol Chem 263: 15681–15687, 1988 PubMedCAS Google Scholar