Picker LJ, Siegelman MH: Lymphoid tissues and organs, in Paul WE (ed.): Fundamental Immunology. New York, Raven Press, 1993, pp. 145–197. Google Scholar
Millet I, Ruddle NH: Differential regulation of lymphotoxin (LT), lymphotoxin-Β (LT-Β), and TNF-α in murine T cell clones activated through the TCR. J Immunol 1994; 152:4336–4346. PubMedCAS Google Scholar
Ferreri NR, Millet I, Askari B, Magnani P, Ruddle NH: Lymphotoxin-Β and TNF regulation in T cell subsets: differential effects of PGE2. Cytokine 1997;9:157–165. ArticlePubMedCAS Google Scholar
Ruddle NH, Waksman BH:Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. II Correlation of the in vitro response with skin reactivity. J Exp Med 1968;128: 1255–1265. ArticlePubMedCAS Google Scholar
Ruddle NH, Bergman CM, McGrath KM, Lingenheld EG, Grunnet ML, Padula SJ, et al.: An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis. J Exp Med 1990;172:1193–1200. ArticlePubMedCAS Google Scholar
Santambrogio L, Hochwald GM, Saxena B, Leu CH, Martz JE, Carlino JA, et al.: Studies on the mechanisms by which TGF-Β protects against allergic encephalomyelitis: antagonism between TGF-Β and TNF J Immunol 1993;151:1116–1127. PubMedCAS Google Scholar
Selmaj K, Raine CS, Cross AH: Anti-tumor necrosis factor therapy abrogates autoimmune demyelination. Ann Neural 1991;30:694–700. ArticleCAS Google Scholar
Powell MB, Mitchell D, Lederman J, Buckmeier J, Zamvil SS, Graham M, et al.: Lymphotoxin and tumor nec-rosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalito-genicity. Int Immunol 1990; 2:539–544. ArticlePubMedCAS Google Scholar
Suen WE, Bergman CM, Hjelmstrom P, Ruddle NH: A critical role for lymphotoxin in experimental allergic encephalomyelitis. J Exp Med 1997;186: 1233–1240. ArticlePubMedCAS Google Scholar
Cuff CA, Schwartz J, Bergman C, Russell KS, Bender JR, Ruddle NH: Lymphotoxin alpha3 induces chemokines and adhesion molecules: Insight into the role of LT alpha in inflammation and lymphoid organ development. J Immunol 1998;161:6853–6860. PubMedCAS Google Scholar
Hochman PS, Majeau GR, Mackay F, Browning JL: Proinflammatory responses are efficiently induced by homotrimeric but not heterotrimeric lymphotoxin ligands. J Inflammation 1996;46:220–234. CAS Google Scholar
Picarella DE, Kratz A, Li C-b, Ruddle NH, Flavell RA: Transgenic TNF-a production in islets leads to insulitis, not diabetes: Distinct patterns of inflammation in TNF-α and TNF-Β transgenic mice. J Immunol 1993; 149:4136–4150. Google Scholar
Picarella DE, Kratz A, Li C-b, Ruddle NH, Flavell RA: Insulitis in transgenic mice expressing TNF-Β (lymphotoxin) in the pancreas. Proc Natl Acad Sci USA 1992;89:10,036–10,040. ArticleCAS Google Scholar
Kratz A, Campos-Neto A, Hanson MS, Ruddle NH: Chronic inflammation caused by lymphotoxin is lymphoid neogenesis. J Exp Med 1996;183:1461–1472. ArticlePubMedCAS Google Scholar
Sacca R, Cuff CA, Lesslauer W, Ruddle NH: Differential activities of secreted lymphotoxin-α3 and membrane lymphotoxin-alΒ2 in lymphotoxin-induced inflammation: Critical role of TNF receptor 1 signaling. J Immunol 1998;160:485–491. PubMedCAS Google Scholar
Sacca R, Cuff CA, Ruddle NH: Mediators of inflammation. Curr Opinion Immunol 1997;9:851–857. ArticleCAS Google Scholar
De Togni P, Goellner J, Ruddle NH, Streeter PR, Fick A, Mariathasan S, et al.: Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science 1994;264:703–707. ArticlePubMedCAS Google Scholar
Matsumoto M, Mariathasan S, Nahm MH, Baranyay F, Peschon JJ, Chaplin DD: Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers. Science 1996; 271:1289–1291. ArticlePubMedCAS Google Scholar
Koni PA, Sacca R, Lawton P, Browning JL, Ruddle NH, Flavell RA: Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice. Immunity 1997;6:491–500. ArticlePubMedCAS Google Scholar
Alimzhanov MB, Kuprash DV, Kosco-Vilbois MH, Luz A, Turetskaya RL, Tarakhovsky A, et al.: Abnormal development of secondary lymphoid tissues in lymphotoxin b-deficient mice. Proc Natl Acad Sci USA 1997;94:9302–9307. ArticlePubMedCAS Google Scholar
Marino MW, Dunn A, Grail D, Inglese M, Noguchi Y, Richards E, et al.: Characterization of tumor necrosis factor-deficient mice. Proc Natl Acad Sci 1997;94:8093–8098. ArticlePubMedCAS Google Scholar
Pasparakis M, Alexopoulou L, Epis-kopou V, Kollias G: Immune and inflammatory responses in TNFα-deficient mice: a critical requirement for TNFα in the formation of networks and germinal centers, and in the maturation of humoral immune response. J Exp Med 1996;184:1397–1411. ArticlePubMedCAS Google Scholar
Mebius R, Rennert P, Weissman IL: Developing lymph nodes collect CD4+CD3-LTb+ cells that can differentiate to APC, NK cells, and follicular dells but not T or B cells. Immunity 1997;7:493–504. ArticlePubMedCAS Google Scholar
Cuff CA, Socca R, Ruddle NH: Differential induction of adhesion molecule and chemokine expression by LTα3 and LTαΒ in inflammation elucidates potential mechanisms of mesentere and peripheral lymph node development. J Immun 1999; 162 (in press).
Forster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M: A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 1996;87:1037–1047. ArticlePubMedCAS Google Scholar
Ngo VN, Korner H, Gunn MD, Schmidt KN, Riminton DS, Cooper MD, et al.: Lymphotoxin a/b and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J Exp Med 1999; 189: 403–412. ArticlePubMedCAS Google Scholar
Mooij P, Wit HJD, Drexhage HA: An excess of dietary iodine accelerates the development of a thyroid-associated lymphoid tissue in autoimmune prone BB rats. Clin Immu-nol Immunopathol 1993; 69:189–198. ArticleCAS Google Scholar
Chilosi, M, Lestani M, Beneditti A, Montagna L, Pedron S, Scarpa A, et al.: Consitutive expression of tenascin in T-dependent zones of human lymphoid tissues. Am J Pathol 1993;143:1348–1355. PubMedCAS Google Scholar
Ziff M Cavender D: The role of endothelium in chronic inflammation, in Poste G, Crooke ST (eds.): Cellular and Molecular Aspects of Inflammation, New York, Plenum Press, 1988, pp. 57–64. Google Scholar
Prineas JW: Multiple sclerosis: Presence of lymphatic capillaries and lymphoid tissue in the brain and spinal cord. Science 1979;203:l123–1125. Article Google Scholar
Raine CS, Cannella B, Duijvestijn AM, Cross AH: Homing to central nervous system vasculature by antigen-specific lymphocytes. II Lymphocyte/endothelial cell adhesion during the initial stages of autoimmune demyelination. Lab Invest 1990;63:476–489. PubMedCAS Google Scholar
Steffen B, Breier G, Butcher EC, Schulz M Engelhardt B: ICAM-1, VCAM-1, and MAdCAM-1 are expressed on choroid plexus epithelium but not endothelium and mediate binding of lymphocytes in vitro. Am J Pathol 1996;148:1819–1838. PubMedCAS Google Scholar
Hanninen A, Taylor C, Streeter PR, Stark LS, Sarte JM, Shizuru JA, et al.: Vascular addressins are induced on islet vessels during insulitis in nonobese diabetic mice and are involved in lymphoid cell binding to islet endothelium. J Clin Invest 1993;92:2509–2515. ArticlePubMedCAS Google Scholar
Faveeuw C, Gagnerault M-C, Lep-ault F: Expression of homing and adhesion molecules in infiltrated islets of Langerhans and salivary glands of nonobese diabetic mice. J Immunol 1994; 152: 5969–5978. PubMedCAS Google Scholar
Lehmann PV, Sercarz EE, Fors-thuber T, Dayan CM, Gammon G: Determinant spreading and the dynamics of the autoimmune T-cell repertoire. Immunol Today 1993; 14:203–208. ArticlePubMedCAS Google Scholar