Interrelation of lymphocyte subpopulations in peripheral blood under cervical papillomavirus infection (original) (raw)

Abstract

T(CD3+)-, B(CD19+)-lymphocytes and their subsets (CD4+, CD8+, CD3+, DR+, CD3− DR+) in peripheral blood of patients with CIN I, CIN II, CIN III and cancer_in situ_ associated with HPV infection were evaluated. In peripheral blood of women with CIN II, CIN III and cancer_in situ_ the number of T-lymphocytes which expressed CD3+ DR+ antigen decreased. In patients with CIN I, CIN III and cancer_in situ_ the level of the CD4+ cells decreased; the level of the CD8+ cells increased. These patients had a lower CD4/CD8 ratio, the number of B cells being standard. The results may have important implications in the prognosis and immunotherapy of HPV infection.

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Authors and Affiliations

1. Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, 252 143, Kiev, Ukraine
   M. Ya. Spivak, L. M. Lazarenko & M. V. Azarskova
2. Bogomolets National Medical University, Kiev, Ukraine
   V. P. Lakatosh, L. M. Lyanenko, O. M. Mikhailenko & A. M. Boroda
3. University of Veterinary Medicine, 041 81, Košice, Slovakia
   L'. Tkáčiková
4. Neuroimmunology Institute, Slovak Academy of Sciences, Bratislava, Slovakia
   L'. Tkáčiková

Authors

1. M. Ya. Spivak
2. V. P. Lakatosh
3. L. M. Lazarenko
4. L. M. Lyanenko
5. M. V. Azarskova
6. O. M. Mikhailenko
7. L'. Tkáčiková
8. A. M. Boroda

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Spivak, M.Y., Lakatosh, V.P., Lazarenko, L.M. et al. Interrelation of lymphocyte subpopulations in peripheral blood under cervical papillomavirus infection.Folia Microbiol 44, 721–725 (1999). https://doi.org/10.1007/BF02825669

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• Received: 08 December 1999
• Issue date: December 1999
• DOI: https://doi.org/10.1007/BF02825669

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