Significance ofHelicobacter pylori infection as a risk factor in gastric cancer: Serological and histological studies (original) (raw)

Abstract

We conducted a case-control study to examine the association of_Helicobacter pylori_ infection as a risk factor in gastric cancer in the Japanese population. Serum IgG antibodies for_Helicobacter pylori_ were determined in 55 consecutive patients with gastric cancer and in 75 age- and sex-matched mass survey subjects and 57 age- and sex-matched cancer-free patients with conditions considered at a high risk for development of gastric cancer (precancerous condition). We examined the histology in all subjects and particular focus was placed on the extent of_Helicobacter pylori_-associated gastritis. The seroprevalence of_Helicobacter pylori_ in gastric cancer patients (82%) and those with a precancerous condition (89%) was significantly higher (P<0.005) than that in the mass survey subjects (60%). Positive relative risk associations were found for patients with gastric cancer (odds ratio, 3, with 95% confidence intervals of 1.69–5.33) and those with a precancerous condition (odds ratio, 5.66, with 95% confidence intervals 2.66–12.03). Significant differences were found when comparisons were made among the case-control groups who were_H. pylori_-positive and had inflammatory cell infiltration (P_=0.0127). The characteristics of_Helicobacter pylori in histologically examined gastric mucosa showed differences between_Helicobacter pylori_-infected and uninfected persons in all groups. However, for none of these groups was there a significant difference between background mucosa for_Helicobacter pylori_-infected persons with or without gastric cancer.Helicobacter pylori seroprevalence is strongly associated with an increased risk of gastric cancer and with a precancerous condition; histological investigation did not define additional factors that might be associated with increased cancer risk.

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References

  1. Aoki K, Minoru K, Sadao S, et al. Death rates for malignant neoplasms for selected sites by sex and 5-year age groups in 33 countries 1953–1957 to 1983–1987. UICC Edition, 1992.
  2. Aoki K. Epidemiology of stomach cancer. In: Nishi M, Ichikawa H, Nakajima T, Maruyama K, Tahara E (eds) Gastric cancer. Tokyo, Heidelberg Berlin New York: Springer 1993:2–15.
    Google Scholar
  3. Fukuda H, Saito D, Hayashi S, et al.Helicobacter pylori infection, serum pepsinogen level and gastric cancer: A case-control study in Japan. Jpn J Cancer Res 1995;86:64–71.
    PubMed CAS Google Scholar
  4. Nomura A, Stemmermann GN, Po-Huang Ch, et al.Helicobacter pylori infection and gastric carcinoma among Japanese Americans In Hawaii. N Engl J Med 1991;325:1132–1136.
    PubMed CAS Google Scholar
  5. Parsonnet, J, Gary D, Friedman DP, et al.Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med 1991;325:1127–1131.
    PubMed CAS Google Scholar
  6. The EUROGAST Study Group. An international association between_Helicobacter pylori_ infection and gastric cancer. Lancet 1993;341:1359–1362.
    Article Google Scholar
  7. Wee A, Kang J, Teh M.Helicobacter pylori and gastric cancer: Correlation with gastritis, intestinal metaplasia, and tumour histology. Gut 1992;33:1029–1032.
    Article PubMed CAS Google Scholar
  8. Barreto ZR, Maruyama M, Kato Y, et al., Gastric cancer and_Helicobacter pylori_ infection: A seroprevalence study in cancer institute hospital Japan. First International Gastric Cancer Congress. Bologna: Monduzzi Editore, 1995:309–312.
    Google Scholar
  9. Hansson LE, Engstrand L, Nyren O, et al.Helicobacter pylori infection: Independent risk indicator of gastric adenocarcinoma. Gastroenterology 1993;105:1098–1103.
    PubMed CAS Google Scholar
  10. Hu P, Mitchell M, Li Y, et al., Association of_Helicobacter pylori_ with gastric cancer and observations on the detection of this bacterium in gastric cancer cases. Am J Gastroenterol 1994;89:1806–1810.
    PubMed CAS Google Scholar
  11. Asaka M, Kudo M, Kato M, et al. The role of_Helicobacter pylori_ infection in the pathogenesis of gastritis. J Gastroenterol 1994; 29:100–104.
    PubMed Google Scholar
  12. Farinati F, Valiante F, Germana B, et al. Prevalence of_Helicobacter pylori_ in patients with precancerous changes and gastric cancer. Eur J Cancer Prev 1993;2:321–326.
    Article PubMed CAS Google Scholar
  13. Sipponen P, Seppala K. Gastric carcinoma: Failed adaptation to_Helicobacter pylori_. Scand J Gastroenterol 1992;27 (Suppl 193): 33–38.
    Article Google Scholar
  14. Goldman H. Gastritis. In: Ming SC, Goldman H (eds) Pathology of the gastrointestinal tract. Philadelphia: Saunders, 1992:481–516.
    Google Scholar
  15. Jass JR, Sobin LH. Precancerous lesions of gastrointestinal tract. A histological classification. In: Morson BC (ed) Precancerous lesions of gastrointestinal tract. London, Philadelphia, Toronto: Balliere Tindall, 1984:1–9.
    Google Scholar
  16. Nishi M, Nakajima T, Kajitani T. General rules for gastric cancer study and analysis of treatment results based on the rules. In: Nishi M (ed) Cancer of stomach Tokyo: Grune and Stratton, 1986:107–121.
    Google Scholar
  17. Lauren P. The two main histological types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma. An attempt at a histological classification. Acta Pathol Microbiol Scand 1965; 64:31–49.
    PubMed CAS Google Scholar
  18. Dawson-Saunders B, Trapp RG, Statistical methods for multiple variables. In: Dawson-Saunders B, Trapp RG (eds) Basic and clinical biostatistics. Tokyo: Appleton and Lange, Prentice Hall of Japan, 1994:210–268.
    Google Scholar
  19. Hirota T, Okada T, Itabashi M. Significance of chronic gastritis as precancerous condition of the stomach. In: Ming SC (ed) Precursors of Gastric Cancer. New York: Praeger, 1984:131–138.
    Google Scholar
  20. Sipponen P, Kosunen Tu, Valle J, et al.,Helicobacter pylori infection and chronic gastritis in gastric cancer. J Clin Pathol 1992;45:319–323.
    Article PubMed CAS Google Scholar
  21. Wilcox MH, Dent THS, Hunter JO, et al., Accuracy of serology for the diagnosis of_Helicobacter pylori_ infection—a comparison of eight kits. J Clin Pathol 1996;46:373–376.
    Article Google Scholar

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  1. R. Barreto-Zuñiga
    Present address: Science and Technology Agency of Japan, Japan

Authors and Affiliations

  1. Department of Gastroenterology, Mexico General Hospital, Mexico
    R. Barreto-Zuñiga & Sahagun F. Bernal
  2. Division of Internal Medicine, Cancer Institute Hospital, 1-37-1 Kami-Ikebukuro Toshima-ku, 170, Tokyo, Japan
    Masakazu Maruyama & Takao Takekoshi
  3. Division of Surgery, Cancer Institute Hospital, 1-37-1 Kami-Ikebukuro Toshima-ku, 170, Tokyo, Japan
    Hirotoshi Ohta
  4. Division of Pathology, Cancer Institute, 1-37-1 Kami-Ikebukuro Toshima-ku, 170, Tokyo, Japan
    Yo Kato & Kenji Aizu

Authors

  1. R. Barreto-Zuñiga
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  2. Masakazu Maruyama
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  3. Yo Kato
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  4. Kenji Aizu
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  5. Hirotoshi Ohta
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  6. Takao Takekoshi
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  7. Sahagun F. Bernal
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Barreto-Zuñiga, R., Maruyama, M., Kato, Y. et al. Significance of_Helicobacter pylori_ infection as a risk factor in gastric cancer: Serological and histological studies.J Gastroenterol 32, 289–294 (1997). https://doi.org/10.1007/BF02934482

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