Cachectin/tumor necrosis factor: An endogenous mediator of shock and inflammation (original) (raw)

• Morgan, H.R.: Pathologic changes produced in rabbits by a toxic somatic antigen derived from_Eberthella typhosa_. Am. J. Path.19: 135–145 (1942).
  Google Scholar
• Brunson, J.G.; Gamble, C.N.; Thomas, L.: Morphologic changes in rabbits following the intravenous administration of meningicoccal toxin. I. The effects produced in young and in mature animals by a single injection. Am. J. Path.31: 489–499 (1955).
  PubMed CAS Google Scholar
• Sultzer, B.M.: Genetic control of leucocyte responses to endotoxin. Nature_219_: 1253–1254 (1968).
  Article PubMed CAS Google Scholar
• Rosenstreich, D.L.; Vogel, S.N.; Jacques, A.R.; Wahl, L.M.; Oppenheim, J.J.: Macrophage sensitivity to endotoxin. Genetic control by a single codominant gene. J. Immun.121: 1664–1670 (1978).
  PubMed CAS Google Scholar
• Apte, R.N.; Pluznik, D.H.: Genetic control of lipopolysaccharide induced generation of serum colony stimulating factor and proliferation of splenic granulocyte/macrophage precursor cells. J. Cell. Physiol.89: 313–323 (1976).
  Article PubMed CAS Google Scholar
• Apte, R.N.; Ascher, O.; Pluznik, D.H.: Genetic analysis of generation of serum interferon by bacterial lipopolysaccharide. J. Immun.119: 1898 (1977).
  PubMed CAS Google Scholar
• Ryan, J.L.; McAdam, K.P.W.J.: Genetic non-responsiveness of murine fibroblasts to bacterial endotoxin. Nature_269_: 153–155 (1977).
  Article PubMed CAS Google Scholar
• Watson, J.; Kelly, K.; Largen, M.; Taylor, B.A.: The genetic mapping of a defective LPS response gene in C3H/HeJ mice. J. Immun.120: 422–424 (1978).
  PubMed CAS Google Scholar
• Michalek, S.M.; Moore, R.N.; McGhee, J.R.; Rosenstreich, D.L.; Mergenhagen, S.E.: The primary role of lymphoreticular cells in the mediation of host responses to bacterial endotoxin. J. infect. Dis.141: 55–63 (1980).
  PubMed CAS Google Scholar
• Moore, R.N.; Goodrum, K.J.; Couch, R.E., Jr.: Berry, L.J.: Elicitation of endotoxemic effects in C3H/HeJ mice with glucocorticoid antagonizing factor and partial characterization of the factor. Infect. Immunity_19_: 79–86 (1978).
  CAS Google Scholar
• Cerami, A.; Ikeda, Y.; Le Trang, N.; Hotez, P.J.; Beutler, B.: Weight loss associated with an endotoxin-induced mediator from peritoneal macrophages: the role of cachectin (tumor necrosis factor). Immunol. Lett.11: 173–177 (1985).
  Article PubMed CAS Google Scholar
• Coley, W.B.: The treatment of malignant tumors by repeated inoculations of erysipelas; with a report of ten original cases. Am. J. med. Sci.105: 487–511 (1983).
  Article Google Scholar
• Shear, M.J.: Chemical treatment of tumors. IX. Reactions of mice with primary subcutaneous tumors to injection of a hemorrhage-producing bacterial polysaccharide. J. natn. Cancer Inst.4: 461–476 (1944).
  CAS Google Scholar
• Shear, M.J.; Andervont, H.B.: Chemical treatment of tumors. III. Separation of hemorrhage-producing fraction of_E. coli_ filtrate. Proc. Soc. exp. Biol. med.34: 323–325 (1936).
  CAS Google Scholar
• Shear, M.J.; Kahler, H.; Hartwell, J.L.: Chemical treatment of tumors. VIII. Ultracentrifugal and electrophoretic analysis of the hemorrhage-producing fraction from_Serratia marcescens_ (bacillus prodigiosus) culture filtrate. J. natn. Cancer Inst.4: 123–129 (1943).
  Google Scholar
• Shear, M.J.; Hartwell, J.L.; Adams, J.R., Jr.: Chemical treatment of tumors. VII. Nature of the hemorrhage-producing fraction from_Serratia marcescens_ (bacillus prodigiosus) culture filtrate. J. natn. Cancer Inst.4: 107–122 (1943).
  Google Scholar
• Shear, M.J.; Turner, F.C.; Perrault, A.; Shovelton, J.: Chemical treatment of tumors. V. Isolation of the hemorrhage-producing fraction from_Serratia marcescens_ (bacillus prodigiosus) culture filtrate. J. natn. Cancer Inst.4: 81–97 (1943).
  CAS Google Scholar
• O'Malley, W.E.; Achinstein, B.; Shear, M.J.: Action of bacterial polysaccharide on tumors. II. Damage of sarcoma 37 by serum of mice treated with_Serratia marcescens_ polysaccharide, and induced tolerance. J. natn. Cancer Inst.29: 1169–1175 (1962).
  Google Scholar
• Carswell, E.A.; Old, L.J.; Kassel, R.L.; Green, S.; Fiore, N.; Williamson, B.: An endotoxin-induced serum factor that causes necrosis of tumors. Proc. natn. Acad. Sci. USA_72_: 3666–3670 (1975).
  Article CAS Google Scholar
• Helson, L.; Green, S.; Carswell, E.; Old, L.J.: Effect of tumour necrosis factor on cultured human melanoma cells. Nature_258_: 731–732 (1975).
  Article PubMed CAS Google Scholar
• Sugarman, B.J.; Aggarwal, B.B.; Hass, P.E.; Figari, I.S.; Palladino, M.A., Jr.; Shepard, H.M.: Recombinant human tumor necrosis factor-alpha: effects on proliferation of normal and transformed cells in vitro. Science_230_: 943–945 (1985).
  Article PubMed CAS Google Scholar
• Algire, G.H.; Legallais, F.Y.; Anderson, B.F.: Vascular reactions of normal and malignant tissues in vivo. V. The role of hypotension in the action of a bacterial polysaccharide on tumors. J. natn. Cancer Inst.12: 1279–1295 (1952).
  CAS Google Scholar
• Aggarwal, B.B.; Kohr, W.J.; Hass, P.E.; Moffat, B.; Spencer, S.A.; Henzel, W.J.; Bringman, T.S.; Nedwin, G.E.; Goeddel, D.V.; Harkins, R.N.: Human tumor necrosis factor. Production, purification, and characterization. J. biol. Chem.260: 2345–2354 (1985).
  PubMed CAS Google Scholar
• Pennica, D.; Nedwin, G.E.; Hayflick, J.S.; Seeburg, P.H.; Derynck, R.; Palladino, M.A.; Kohr, W.J.; Aggarwal, B.B.; Goeddel, D.V.: Human tumor necrosis factor: precursors structure, expression and homology to lymphotoxin. Nature_312_: 724–729 (1984).
  Article PubMed CAS Google Scholar
• Wang, A.M.; Creasey, A.A.; Ladner, M.B.; Lin, L.S.; Strickler, J.; Van Arsdell, J.N.; Yamamoto, R.; Mark, D.F.: Molecular cloning of the complementary DNA for human tumor necrosis factor. Science_228_: 149–154 (1985).
  Article PubMed CAS Google Scholar
• Shirai, T.; Yamaguchi, H.; Ito, H.; Todd, C.W.; Wallace, R.B.: Cloning and expression in_Escherichia coli_ of the gene for human tumour necrosis factor. Nature_313_: 803–806 (1985).
  Article PubMed CAS Google Scholar
• Nedwin, G.E.; Naylor, S.L.; Sakaguchi, A.Y.; Smith, D.; Jarrett-Nedwin, J.; Pennica, D.; Goeddel, D.V.; Gray, P.W.: Human lymphotoxin and tumor necrosis factor genes: structure homology and chromosomal localization. Nucl. Acids Res.13: 6361–6373 (1985).
  Article PubMed CAS Google Scholar
• Rouzer, C.A.; Cerami, A.: Hypertriglyceridemia associated with_Trypanosoma brucei_ infection in rabbits: role of defective triglyceride removal. Molec. biochem. Parasitol.2: 31–38 (1980).
  Article CAS Google Scholar
• Guy, M.W.: Serum and tissue fluid lipids in rabbits experimentally infected with_Trypanosoma brucei_. Trans. R. Soc. trop. Med. Hyg.69: 429 (1975).
  Google Scholar
• Kawakami, M.; Cerami, A.: Studies of endotoxin-induced decrease in lipoprotein lipase activity. J. exp. Med.154: 631–639 (1981).
  Article PubMed CAS Google Scholar
• Kawakami, M.; Pekala, P.H.; Lane, M.D.; Cerami, A.: Lipoprotein lipase suppression in 3T3-L1 cells by an endotoxin-induced mediator from exudate cells. Proc. natn. Acad. Sci. USA_79_: 912–916 (1982).
  Article CAS Google Scholar
• Beutler, B.; Mahoney, J.; Le Trang, N.; Pekala, P.; Cerami, A.: Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells. J. exp. Med.161: 984–995 (1985).
  Article PubMed CAS Google Scholar
• Beutler, B.; Milsark, I.W.; Cerami, A.: Cachectin/tumor necrosis factor: production, distribution, and metabolic fate in vivo. J. Immun.135: 3972–3977 (1985).
  PubMed CAS Google Scholar
• Abe, S.; Gatanaga, T.; Yamazaki, M.; Soma, G.; Mizuno, D.: Purification of rabbit tumor necrosis factor. FEBS Lett.180: 203–206 (1985).
  Article PubMed CAS Google Scholar
• Beutler, B.; Greenwald, D.; Hulmes, J.D.; Chang, M.; Pan, Y.-C.E.; Mathison, J.; Ulevitch, R.; Cerami, A.: Identity of tumour necrosis factor and the macrophage-secreted factor cachectin. Nature_316_: 552–554 (1985).
  Article PubMed CAS Google Scholar
• Caput, D.; Beutler, B.; Hartog, K.; Brown-Shimer, S.; Cerami, A.: Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators. Proc. natn. Acad. Sci. USA_83_: 1670–1674 (1986).
  Article CAS Google Scholar
• Pennica, D.; Hayflick, J.S.; Bringman, T.S.; Palladino, M.A.; Goeddel, D.V.: Cloning and expression in_Escherichia coli_ of the cDNA for murine tumor necrosis factor. Proc. natn. Acad. Sci. USA_82_: 6060–6064 (1985).
  Article CAS Google Scholar
• Fransen, L.; Müller, R.; Marmenout, A.; Tavernier, J.; Heyden, J. van der; Kawashima, E.; Chollet, A.; Tizard, R.; Heuverswyn, H. van; Vliet, A. van; Ruysschaert, M.-R.; Fiers, W.: Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expression. Nucl. Acids Res.13: 4417–4429 (1985).
  Article PubMed CAS Google Scholar
• Beutler, B.; Milsark, I.W.; Cerami, A.: Passive immunization against cachectin/tumor necrosis factor (TNF) protects mice from the lethal effect of endotoxin Science_229_: 869–871 (1985).
  Article PubMed CAS Google Scholar
• Tracey, K.J.; Beutler, B.; Lowry, S.F.; Merryweather, J.; Wolpe, S.; Milsark, I.W.; Hariri, R.J.; Fahey, T.J., III.; Zentella, A.; Albert, J.D.; Shires, G.T.; Cerami, A.: Shock and tissue injury induced by recombinant human cachectin. Science_234_: 470–474 (1986).
  Article PubMed CAS Google Scholar
• Terashita, Z.Y.; Imura, Y.; Nishikawa, K.; Sumida, S.: Is platelet activating factor (PAF) a mediator of endotoxin shock? Eur. J. Pharmacol.109: 257–261 (1985).
  Article PubMed CAS Google Scholar
• Doebber, T.W.; Wu, M.S.; Robbins, J.C.; Choy, B.M.; Chang, M.N.; Shen, T.Y.: Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. Studies with PAF-receptor antagonist kadsurenone. Biochem. biophys. Res. Commun.127: 799–808 (1985).
  Article PubMed CAS Google Scholar
• Dahlen, S.-E.; Bjork, J.; Hedqvist, P.; Arfors, K.-E.; Hammarstrom, S.; Lindgren, J.-A.; Samuelsson, B.: Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response. Proc. natn. Acad. Sci. USA_78_: 3887–3891 (1981).
  Article CAS Google Scholar
• Bremm, K.D.; Konig, W.; Spur, B.; Crea, A.; Galanos, C.: Generation of slow-reacting substance (leukotrienes) by endotoxin and lipid A from human polymorphonuclear granulocytes. Immunology_53_: 299–305 (1984).
  PubMed CAS Google Scholar
• Hagmann, W.; Keppler, D.: Leukotriene antagonists prevent endotoxin lethality. Naturwissenschaften_69_: 594–595 (1982).
  Article PubMed CAS Google Scholar
• Beutler, B.; Cerami, A.: Recombinant interleukin 1 suppresses lipoprotein lipase activity in 3T3-L1 cells. J. Immun.135: 3969–3971 (1985).
  PubMed CAS Google Scholar
• Patton, J.S.; Shepard, H.M.; Wilking, H.; Lewis, G.; Aggarwal, B.B.; Eessalu, T.E.; Gavin, L.A.; Grunfeld, C.: Interferons and tumor necrosis factors have similar catabolic effects on 3T3 L1 cells. Proc. natn. Acad. Sci. USA (in press, 1986).
• Beutler, B.; Mahoney, J.; Pekala, P.; Le Trang, N.; Cerami, A.: The major endotoxin-inducible secretory product of cultured macrophages is a novel lipolytic hormone. Blood_64_: 65a (1984).
  Google Scholar
• Torti, F.M.; Dieckmann, B.; Beutler, B.; Cerami, A.; Ringold, G.M.: A macrophage factor inhibits adipocyte gene expression: an in vitro model of cachexia. Science_229_: 867–869 (1985).
  Article PubMed CAS Google Scholar
• Collins, T.; Lapierre, L.A.; Fiers, W.; Strominger, J.L.; Pober, J.S.: Recombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA-A,B antigens in vascular endothelial cells and dermal fibroblasts in vitro. Proc. natn. Acad. Sci. USA_83_: 446–450 (1986).
  Article CAS Google Scholar
• Pober, J.S.; Bevilacqua, M.P.; Mendrick, D.L.; Lapierre, L.A.; Fiers, W.; Gimbrone, M.A., Jr.: Two distinct monokines, interleukin-1 and tumor necrosis factor, each independently induce biosynthesis and transient expression of the same antigen on the surface of cultured human vascular endothelial cells. J. Immun.136: 1680–1687 (1986).
  PubMed CAS Google Scholar
• Bachwich, P.R.; Chensue, S.W.; Larrick, J.W.; Kunkel, S.L.: Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages. Biochem. biophys. Res. Commun.136: 94–101 (1986).
  Article PubMed CAS Google Scholar
• Nawroth, P.; Bank, I.; Handley, D.; Cassimeris, J.; Chess, L.; Stern, D.: Tumor necrosis factor/cachectin interacts with endothelial cell receptors to induce release of interleukin-1. J. exp. Med.163: 1363–1375 (1986).
  Article PubMed CAS Google Scholar
• Dinarello, C.A.; Cannon, J.G.; Wolff, S.M.; Bernheim, H.A.; Beutler, B.; Cerami, A.; Palladino, M.A.; O'Connor, J.V.: Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin-1. J. exp. Med.163: 1433–1450 (1986).
  Article PubMed CAS Google Scholar
• Kohase, M.; Henriksen DeStefano, D.; May, L.T.; Vilcek, J.; Sehgal, P.B.: Induction of beta 2-interferon by tumor necrosis factor: a homeostatic mechanism in the control of cell proliferation. Cell_45_: 659–666 (1986).
  Article PubMed CAS Google Scholar
• Libby, P.; Ordovas, J.M.; Auger, K.R.; Robbins, A.H.; Birinyi, L.K.; Dinarello, C.A.: Endotoxin and tumor necrosis factor induce interleukin-1 gene expression in adult human vascular endothelial cells. Am. J. Path.124: 179–185 (1986).
  PubMed CAS Google Scholar
• Kirstein, M.; Baglioni, C.: Tumor necrosis factor induces synthesis of two proteins in human fibroblasts. J. biol. Chem.261: 9565–9567 (1986).
  PubMed CAS Google Scholar
• Gamble, J.R.; Harlan, J.M.; Klebanoff, S.J.; Lopez, A.F.; Vadas, M.A.: Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor. Proc. natn. Acad. Sci. USA_82_: 8667–8671 (1985).
  Article CAS Google Scholar
• Shalaby, M.R.; Aggarwal, B.B.; Rinderknecht, E.; Svedersky, L.P.; Finkle, B.S.; Palladino, M.A., Jr.: Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors. J. Immun.135: 2069–2073 (1985).
  PubMed CAS Google Scholar
• De Titto, E.H.; Catterall, J.R.; Remington, J.S.: Activity of recombinant tumor necrosis factor on_Toxoplasma gondii_ and_Trypanosoma cruzi_. J. Immun.137: 1342–1345 (1986).
  PubMed Google Scholar
• Murphy, M.; Loudon, R.; Kobayashi, M.; Trinchieri, G.: Gamma interferon and lymphotoxin, released by activated T cells, synergize to inhibit granulocyte/monocyte colony formation. J. exp. Med.164: 263–279 (1986).
  Article PubMed CAS Google Scholar
• Takeda, K.; Iwamoto, S.; Sugimoto, H.; Takuma, T.; Kawatani, N.; Noda, M.; Masaki, A.; Morise, H.; Arimura, H.; Konno, K.: Identity of differentiation inducing factor and tumour necrosis factor. Nature_323_: 338–340 (1986).
  Article PubMed CAS Google Scholar
• Trinchieri, G.; Kobayashi, M.; Rosen, M.; Loudon, R.; Murphy, M.; Perussia, B.: Tumor necrosis factor and lymphotoxin induce differentiation of human myeloid cell lines in synergy with immune interferon. J. exp. Med.164: 1206–1225 (1986).
  Article PubMed CAS Google Scholar
• Degliantoni, G.; Murphy, M.; Kobayashi, M.; Francis, M.K.; Perussia, B.; Trinchieri, G.: Natural killer (NK) cell-derived hematopoietic colony-inhibiting activity and NK cytotoxic factor. Relationship with tumor necrosis factor and synergism with immune interferon. J. exp. Med.162: 1512–1530 (1985).
  Article PubMed CAS Google Scholar
• Ortaldo, J.R.; Mason, L.H.; Mathieson, B.J.; Liang, S.M.; Flick, D.A.; Herberman, R.B.: Mediation of mouse natural cytotoxic activity by tumour necrosis factor. Nature_321_: 700–702 (1986).
  Article PubMed CAS Google Scholar
• Silberstein, D.S.; David, J.R.: Tumor necrosis factor enhances eosinophil toxicity to_Schistosoma mansoni_ larvae. Proc. natn. Acad. Sci. USA_83_: 1055–1059 (1986).
  Article CAS Google Scholar
• Stolpen, A.H.; Guinan, E.C.; Fiers, W.; Pober, J.S.: Recombinant tumor necrosis factor and immune interferon act singly and in combination to reorganize human vascular endothelial cell monolayers. Am. J. Path.123: 16–24 (1986).
  PubMed CAS Google Scholar
• Sato, N.; Goto, T.; Haranaka, K.; Satomi, N.; Nariuchi, H.; Mano Hirano, Y.: Actions of tumor necrosis factor on cultured vascular endothelial cells: morphologic modulation, growth inhibition, and cytotoxicity. J. natn. Cancer Inst.76: 1113–1121 (1986).
  CAS Google Scholar
• Pohlman, T.H.; Stanness, K.A.; Beatty, P.G.; Ochs, H.D.; Harlan, J.M.: An endothelial cell surface factor(s) induced in vitro by lipopolysaccharide, interleukin-1, and tumor necrosis factor-alpha increases neutrophil adherence by a CDw18-dependent mechanism. J. Immun.136: 4548–4553 (1986).
  PubMed CAS Google Scholar
• Bevilacqua, M.P.; Pober, J.S.; Majeau, G.R.; Fiers, W.; Cotran, R.S.; Gimbrone, M.A., Jr.: Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin-1. Proc. natn. Acad. Sci. USA_83_: 4533–4537 (1986).
  Article CAS Google Scholar
• Stern, D.M.; Nawroth, P.P.: Modulation of endothelial hemostatic properties by tumor necrosis factor. J. exp. Med.163: 740–745 (1986).
  Article PubMed Google Scholar
• Bertolini, D.R.; Nedwin, G.; Bringman, T.; Smith, D.; Mundy, G.R.: Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factor. Nature_319_: 516–518 (1986).
  Article PubMed CAS Google Scholar
• Saklatvala, J.: Tumour necrosis factor-α stimulates resorption and inhibits synthesis of proteoglycan in cartilage. Nature_322_: 547–549 (1986).
  Article PubMed CAS Google Scholar
• Dayer, J.-M.; Beutler, B.; Cerami, A.: Cachectin/tumor necrosis factor (TNF) stimulates collagenase and PGE2 production by human synovial cells and dermal fibroblasts. J. exp. Med.162: 2163–2168 (1985).
  Article PubMed CAS Google Scholar
• Aderka, D.; Holtmann, H.; Toker, L.; Hahn, T.; Wallach, D.: Tumor necrosis factor induction by Sendai virus. J. Immun.136: 2938–2942 (1986).
  PubMed CAS Google Scholar
• Beutler, B.; Krochin, N.; Milsark, I.W.; Goldberg, A.; Cerami, A.: Induction of cachectin (tumor necrosis factor) synthesis by influenza virus: deficient production by endotoxin-resistant (C3H/HeJ) macrophages. Clin. Res.34: 491a (1986).
  Google Scholar
• Nedwin, G.E.; Svedersky, L.P.; Bringman, T.S.; Palladino, M.A.; Goeddel, D.V.: Effect of interleukin-2, interferon-gamma, and mitogens on the production of tumor necrosis factors alpha and beta. J. Immun.135: 2492–2497 (1985).
  PubMed CAS Google Scholar
• Ikejima, T.; Minami, M.; Gill, D.M.; Dinarello, C.A.: Human, rabbit and murine interleukin-1 production in response to toxic shock syndrome toxin-1 (submitted, 1985).
• Beutler, B.; Krochin, N.; Milsark, I.W.; Luedke, C.; Cerami, A.: Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance. Science_232_: 977–980 (1986).
  Article PubMed CAS Google Scholar
• Beutler, B.; Tkacenko, V.; Milsark, I.W.; Krochin, N.; Cerami, A.: The effect of interferon-gamma on cachectin expression by mononuclear phagocytes: reversal of the lps-d (endotoxin resistance) phenotype. J. exp. Med. (in press, 1986).
• Shaw, G.; Kamen, R.: A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell_46_: 659–667 (1986).
  Article PubMed CAS Google Scholar
• Gifford, G.E.; Lohmann-Matthes, M.L.: Requirement for the continual presence of lipopolysaccharide for production of tumor necrosis factor by thioglycollate-induced peritoneal murine macrophages. Int. J. Cancer_38_: 135–137 (1986).
  Article PubMed CAS Google Scholar
• Conta, B.S.; Powell, M.B.; Ruddle, N.H.: Activation of LyT-1+ and LyT-2+ T cell cloned lines: stimulation of proliferation, lymphokine production, and self-destruction. J. Immun.134: 2185–2190 (1985).
  PubMed CAS Google Scholar
• Tsujimoto, M.; Vilcek, J.: Tumor necrosis factor receptors in HeLa cells and their regulation by interferon-gamma. J. biol. Chem.261: 5384–5388 (1986).
  PubMed CAS Google Scholar
• Lehmann, V.; Droge, W.: Demonstration of membrane receptors for human natural and recombinant 125I-labeled tumor necrosis factor on HeLa cell clones and their role in tumor cell sensitivity. Eur. J. Biochem.158: 1–5 (1986).
  Article PubMed CAS Google Scholar
• Aggarwal, B.B.; Eessalu, T.E.; Hass, P.E.: Characterization of receptors for human tumour necrosis factor and their regulation by gamma-interferon. Nature_318_: 665–667 (1985).
  Article PubMed CAS Google Scholar
• Tsujimoto, M.; Yip, Y.K.; Vilcek, J.: Tumor necrosis factor: Specific binding and internalizating in sensitive and resistant cells. Proc. natn. Acad. Sci. USA_82_: 7626–7630 (1985).
  Article CAS Google Scholar
• Ruggiero, V.; Tavernier, J.; Fiers, W.; Baglioni, C.: Induction of the synthesis of tumor necrosis factor receptors by interferon-gamma. J. Immun. (in press, 1986)
• Kull, F.C., Jr.; Jacobs, S.; Cuatrecasas, P.: Cellular receptor for [125]I-labeled tumor necrosis factor: specific binding, affinity labeling, and relationship to sensitivity. Proc. natn. Acad. Sci. USA_82_: 5756–5760 (1985).
  Article CAS Google Scholar
• Aggarwal, B.B.; Traquina, P.R.; Eessalu, T.E.: Modulation of receptors and cytotoxic response of tumor necrosis factor-alpha by various lectins. J. biol. Chem.262: 1–5 (1986).
  Google Scholar
• Ito, H.; Yamamoto, S.; Kuroda, S.; Sakamoto, H.; Kajihara, J.; Kiyota, T.; Hayashi, H.; Kato, M.; Seko, M.: Molecular cloning and expression in_Escherichia coli_ of the cDNA coding for rabbit tumor necrosis factor. DNA_5_: 149–156 (1986).
  PubMed CAS Google Scholar
• Ito, H.; Shirai, T.; Yamamoto, S.; Akira, M.; Kawahara, S.; Todd, C.W.; Wallace, R.B.: Molecular cloning of the gene encoding rabbit tumor necrosis factor. DNA_5_: 157–165 (1986).
  Article PubMed CAS Google Scholar
• Haranaka, K.; Satomi, N.; Sakurai, A.; Nariuchi, H.: Purification and partial amino acid sequence of rabbit tumor necrosis factor. Int. J. Cancer_36_: 395–400 (1985).
  PubMed CAS Google Scholar