Tissue injury in neutrophilic inflammation (original) (raw)
Abstract.
The exudation of neutrophils is the hallmark of a form of inflammatory response occurring after tissue colonization by invading bacteria or as an expression of various non-infectious diseases. All these diseases are characterized by a high risk of developing irreversible tissue injury. Neutrophil-endothelium interactions, activation-induced functional and structural changes of responding neutrophils, regulatory systems of neutrophil function, and oxidative-proteolytic pathways responsible for histotoxicity are reviewed here. Finally, perspectives for rational approaches to handle the development of tissue injury during neutrophilic inflammation are considered.
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Authors and Affiliations
- First Medical Clinic, Department of Internal Medicine, University of Genova, Medical School, Viale Benedetto XV 6, I-16132 Genova, Italy, Fax +39 10 352 324, , , , , , IT
F. Dallegri & L. Ottonello
Authors
- F. Dallegri
- L. Ottonello
Additional information
Received 14 April 1997; returned for revision 5 June 1997; accepted by M. J. Parnham 30 June 1997
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Dallegri, F., Ottonello, L. Tissue injury in neutrophilic inflammation.Inflamm. res. 46, 382–391 (1997). https://doi.org/10.1007/s000110050208
- Issue date: October 1997
- DOI: https://doi.org/10.1007/s000110050208