Cancer and blood coagulation (original) (raw)
Abstract.
In human patients, blood coagulation disorders often associate with cancer, even in its early stages. Recently, in vitro and in vivo experimental models have shown that oncogene expression, or inactivation of tumour suppressor genes, upregulate genes that control blood coagulation. These studies suggest that activation of blood clotting, leading to peritumoral fibrin deposition, is instrumental in cancer development. Fibrin can indeed build up a provisional matrix, supporting the invasive growth of neoplastic tissues and blood vessels. Interference with blood coagulation can thus be considered as part of a multifaceted therapeutic approach to cancer.
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Authors and Affiliations
- Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Turin Medical School, Str. Prov. 142, 10060, Candiolo, Italy
C. Boccaccio - Oncogenomics Center, Institute for Cancer Research and Treatment (IRCC), University of Turin Medical School, Str. Prov. 142, 10060, Candiolo, Italy
E. Medico
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- C. Boccaccio
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Correspondence toC. Boccaccio.
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Received 30 November 2005; received after revision 7 February 2005; accepted 8 February 2006
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Boccaccio, C., Medico, E. Cancer and blood coagulation.Cell. Mol. Life Sci. 63, 1024–1027 (2006). https://doi.org/10.1007/s00018-005-5570-9
- Published: 14 April 2006
- Issue Date: May 2006
- DOI: https://doi.org/10.1007/s00018-005-5570-9