Membrane traffic in the secretory pathway (original) (raw)

Abstract.

Cholesterol, certain lipids, membrane-bound and soluble proteins, as well as viruses that are synthesized in the endoplasmic reticulum (ER), reach the plasma membrane (PM) via non-classical pathway(s) that remain poorly understood. Typical for this transport is (i) its insensitivity to brefeldin A (BFA), which dissociates selected coat complexes from membranes, resulting in the disassembly of the Golgi apparatus; (ii) its rapid kinetics as compared to the classical secretory pathway; and (iii) its role in the trafficking of lipid raft components. Based on results showing that the intermediate compartment (IC) at the ER-Golgi boundary constitutes a stable tubular network that maintains its dynamics in the presence of BFA, we propose that two bidirectional Golgi-bypass pathways to the PM exist, a direct route from early IC elements, and another, reminescent of the yeast secretory pathway, from late IC elements via the endosomal system. These pathways have implications for the organization of the secretory processes in different cell types. (Part of a Multi-author Review)

Article PDF

Similar content being viewed by others

Author information

Author notes

  1. R. Sannerud
    Present address: Department of Molecular and Developmental Genetics, Laboratory for Membrane Trafficking, KULeuven/VIB11, B-3000, Leuven, Belgium

Authors and Affiliations

  1. Section of Anatomy and Cell Biology, Department of Biomedicine, University of Bergen, Jonas Lies Vei 91, 5009, Bergen, Norway
    M. Marie, R. Sannerud & J. Saraste
  2. Molecular Imaging Center, Department of Biomedicine, University of Bergen, Jonas Lies Vei 91, 5009, Bergen, Norway
    H. Avsnes Dale

Authors

  1. M. Marie
    You can also search for this author inPubMed Google Scholar
  2. R. Sannerud
    You can also search for this author inPubMed Google Scholar
  3. H. Avsnes Dale
    You can also search for this author inPubMed Google Scholar
  4. J. Saraste
    You can also search for this author inPubMed Google Scholar

Corresponding author

Correspondence toJ. Saraste.

Rights and permissions

About this article

Cite this article

Marie, M., Sannerud, R., Avsnes Dale, H. et al. Membrane traffic in the secretory pathway.Cell. Mol. Life Sci. 65, 2859–2874 (2008). https://doi.org/10.1007/s00018-008-8355-0

Download citation

Keywords.