Biology of FGFRL1, the fifth fibroblast growth factor receptor (original) (raw)
Beenken A, Mohammadi M (2009) The FGF family: biology, pathophysiology and therapy. Nat Rev Drug Discov 8:235–253 ArticleCASPubMed Google Scholar
Itoh N, Ornitz DM (2004) Evolution of the Fgf and Fgfr gene families. Trends Genet 20:563–569 ArticleCASPubMed Google Scholar
Eswarakumar VP, Lax I, Schlessinger J (2005) Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev 16:139–149 ArticleCASPubMed Google Scholar
Mohammadi M, Olsen SK, Ibrahimi OA (2005) Structural basis for fibroblast growth factor receptor activation. Cytokine Growth Factor Rev 16:107–137 ArticleCASPubMed Google Scholar
Wilkie AO (2005) Bad bones, absent smell, selfish testes: the pleiotropic consequences of human FGF receptor mutations. Cytokine Growth Factor Rev 16:187–203 ArticleCASPubMed Google Scholar
Knowles MA (2007) Role of FGFR3 in urothelial cell carcinoma: biomarker and potential therapeutic target. World J Urol 25:581–593 ArticleCASPubMed Google Scholar
Jackson CC, Medeiros LJ, Miranda RN (2010) 8p11 myeloproliferative syndrome: a review. Hum Pathol 41:461–476 ArticleCASPubMed Google Scholar
Wiedemann M, Trueb B (2000) Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors. Genomics 69:275–279 ArticleCASPubMed Google Scholar
Kim I, Moon S-O, Yu K-H, Kim U-H, Koh GY (2001) A novel fibroblast growth factor receptor-5 preferentially expressed in the pancreas. Biochim Biophys Acta 1518:152–156 CASPubMed Google Scholar
Sleeman M, Fraser J, McDonald M, Yuan S, White D, Grandison P, Kumble K, Watson JD, Murison JG (2001) Identification of a new fibroblast growth factor receptor, FGFR5. Gene 271:171–182 ArticleCASPubMed Google Scholar
Trueb B, Zhuang L, Taeschler S, Wiedemann M (2003) Characterization of FGFRL1, a novel FGF receptor preferentially expressed in skeletal tissues. J Biol Chem 278:33857–33865 ArticleCASPubMed Google Scholar
Trueb B, Taeschler S (2006) Expression of FGFRL1, a novel fibroblast growth factor receptor, during embryonic development. Int J Mol Med 17:617–620 CASPubMed Google Scholar
Wiedemann M, Trueb B (2001) The mouse Fgfrl1 gene coding for a novel FGF receptor-like protein. Biochim Biophys Acta 1520:247–250 CASPubMed Google Scholar
Hayashi S, Itoh M, Taira S, Agata K, Taira M (2004) Expression patterns of Xenopus FGF receptor-like 1/nou-darake in early Xenopus development resemble those of planarian nou-darake and Xenopus FGF8. Dev Dyn 230:700–707 ArticleCASPubMed Google Scholar
Beyeler M, Trueb B (2006) Fgfrl1, a fibroblast growth factor receptor-like gene, is found in the cephalochordate Branchiostoma floridae but not in the urochordate Ciona intestinalis. Comp Biochem Physiol Part B 145:43–49 Article Google Scholar
Trueb B, Neuhauss SCF, Baertschi S, Rieckmann T, Schild C, Taeschler S (2005) Fish possess multiple copies of fgfrl1, the gene for a novel FGF receptor. Biochim Biophys Acta 1727:65–74 CASPubMed Google Scholar
Zhuang L, Karotki AV, Bruecker P, Trueb B (2009) Comparison of the receptor FGFRL1 from sea urchins and humans illustrates evolution of a zinc binding motif in the intracellular domain. BMC Biochemistry 10:33 ArticlePubMed Google Scholar
Bertrand S, Somorjai I, Garcia-Fernandez J, Lamonerie T, Escriva H (2009) FGFRL1 is a neglected putative actor of the FGF signalling pathway present in all major metazoan phyla. BMC Evol Biol 9:226 ArticlePubMed Google Scholar
Putnam NH, Srivastava M, Hellsten U, Dirks B, Chapman J, Salamov A, Terry A, Shapiro H, Lindquist E, Kapitonov VV, Jurka J, Genikhovich G, Grigoriev IV, Lucas SM, Steele RE, Finnerty JR, Technau U, Martindale MQ, Rokhsar DS (2007) Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization. Science 317:86–94 ArticleCASPubMed Google Scholar
Steinberg F, Zhuang L, Beyeler M, Kalin RE, Mullis PE, Brandli AW, Trueb B (2010) The FGFRL1 receptor is shed from cell membranes, binds FGFs and antagonizes FGF signaling in Xenopus embryos. J Biol Chem 285:2193–2202 ArticleCASPubMed Google Scholar
Rieckmann T, Kotevic I, Trueb B (2008) The cell surface receptor FGFRL1 forms constitutive dimers that promote cell adhesion. Exp Cell Res 314:1071–1081 ArticleCASPubMed Google Scholar
Rieckmann T, Zhuang L, Flück CE, Trueb B (2009) Characterization of the first FGFRL1 mutation identified in a craniosynostosis patient. Biochim Biophys Acta 1792:112–121 CASPubMed Google Scholar
Zhuang L, Falquet L, Trueb B (2010) Genome-wide comparison of FGFRL1 with structurally related surface receptors. Exp Ther Med 1:161–168 CAS Google Scholar
Baertschi S, Zhuang L, Trueb B (2007) Mice with a targeted disruption of the Fgfrl1 gene die at birth due to alterations in the diaphragm. FEBS J 274:6241–6253 ArticleCASPubMed Google Scholar
Plotnikov AN, Schlessinger J, Hubbard SR, Mohammadi M (1999) Structural basis for FGF receptor dimerization and activation. Cell 98:641–650 ArticleCASPubMed Google Scholar
Plotnikov AN, Hubbard SR, Schlessinger J, Mohammadi M (2000) Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Cell 101:413–424 ArticleCASPubMed Google Scholar
Ibrahimi OA, Zhang F, Eliseenkova AV, Itoh N, Linhardt RJ, Mohammadi M (2004) Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities. Hum Mol Genet 13:2313–2324 ArticleCASPubMed Google Scholar
Mohammadi M, Olsen SK, Goetz R (2005) A protein canyon in the FGF-FGF receptor dimer selects from an à la carte menu of heparan sulfate motifs. Curr Opin Struct Biol 15:506–516 ArticleCASPubMed Google Scholar
Kan M, Wang F, Xu J, Crabb JW, Hou J, McKeehan WL (1993) An essential heparin-binding domain in the fibroblast growth factor receptor kinase. Science 259:1918–1921 ArticleCASPubMed Google Scholar
Powell AK, Fernig DG, Turnbull JE (2002) Fibroblast growth factor receptors 1 and 2 interact differently with heparin/heparan sulfate. Implications for dynamic assembly of a ternary signaling complex. J Biol Chem 277:28554–28563 ArticleCASPubMed Google Scholar
Loo BM, Kreuger J, Jalkanen M, Lindahl U, Salmivirta M (2001) Binding of heparin/heparan sulfate to fibroblast growth factor receptor 4. J Biol Chem 276:16868–16876 ArticleCASPubMed Google Scholar
Mantovani A, Locati M, Vecchi A, Sozzani S, Allavena P (2001) Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines. Trends Immunol 22:328–336 ArticleCASPubMed Google Scholar
Long EO (2008) Negative signaling by inhibitory receptors: the NK cell paradigm. Immunol Rev 224:70–84 ArticleCASPubMed Google Scholar
Crocker PR, Redelinghuys P (2008) Siglecs as positive and negative regulators of the immune system. Biochem Soc Trans 36:1467–1471 ArticleCASPubMed Google Scholar
Daeron M, Jaeger S, Du Pasquier L, Vivier E (2008) Immunoreceptor tyrosine-based inhibition motifs: a quest in the past and future. Immunol Rev 224:11–43 ArticleCASPubMed Google Scholar
Pinheiro da Silva F, Aloulou M, Benhamou M, Monteiro RC (2008) Inhibitory ITAMs: a matter of life and death. Trends Immunol 29:366–373 ArticlePubMed Google Scholar
Steinberg F, Gerber S, Rieckmann T, Trueb B (2010) Rapid fusion and syncytium formation of heterologous cells upon expression of the FGFRL1 receptor. J Biol Chem 285. doi: 10.1074/jbc.M110.140517
Oren-Suissa M, Podbilewicz B (2010) Evolution of programmed cell fusion: common mechanisms and distinct functions. Dev Dyn 239:1515–1528 ArticleCASPubMed Google Scholar
Cebria F, Kobayashi C, Umesono Y, Nakazawa M, Mineta K, Ikeo K, Gojobori T, Itoh M, Taira M, Sanchez Alvarado A, Agata K (2002) FGFR-related gene nou-darake restricts brain tissues to the head region of planarians. Nature 419:620–624 ArticleCASPubMed Google Scholar
Ogawa K, Kobayashi C, Hayashi T, Orii H, Watanabe K, Agata K (2002) Planarian fibroblast growth factor receptor homologs expressed in stem cells and cephalic ganglions. Dev Growth Differ 44:191–204 ArticleCASPubMed Google Scholar
Hall C, Flores MV, Murison G, Crosier K, Crosier P (2006) An essential role for zebrafish Fgfrl1 during gill cartilage development. Mech Dev 123:925–940 ArticleCASPubMed Google Scholar
Hogan BM, Hunter MP, Oates AC, Crowhurst MO, Hall NE, Heath JK, Prince VE, Lieschke GJ (2004) Zebrafish gcm2 is required for gill filament budding from pharyngeal ectoderm. Dev Biol 276:508–522 ArticleCASPubMed Google Scholar
Hanaoka R, Ohmori Y, Uyemura K, Hosoya T, Hotta Y, Shirao T, Okamoto H (2004) Zebrafish gcmb is required for pharyngeal cartilage formation. Mech Dev 121:1235–1247 ArticleCASPubMed Google Scholar
Amaya E, Stein PA, Musci TJ, Kirschner MW (1993) FGF signalling in the early specification of mesoderm in Xenopus. Development 118:477–487 CASPubMed Google Scholar
Gerber S, Steinberg F, Beyeler M, Villiger PM, Trueb B (2009) The murine Fgfrl1 receptor is essential for the development of the metanephric kidney. Dev Biol 335:106–119 ArticleCASPubMed Google Scholar
Potter EL (1962) Pathology of the fetus and infant, 2nd edn. Year Book Medical, Chicago Google Scholar
Gubler MC, Antignac C (2010) Renin-angiotensin system in kidney development: renal tubular dysgenesis. Kidney Int 77:400–406 ArticleCASPubMed Google Scholar
Anderson SJ, Brennan J, de Sauvage FJ, Ding Z, Edwards J, Fikes NA, Huang W, Ouyang W, Rangel C, Sangha M, Shi Z-Z, Sparks MJ, Trackey J, Vetter M, Wang C-Y, Woodings J (2007) Novel gene disruptions, compositions and methods relating thereto. US Patent 20070292438
Catela C, Bilbao-Cortes D, Slonimsky E, Kratsios P, Rosenthal N, Te Welscher P (2009) Multiple congenital malformations of Wolf-Hirschhorn syndrome are recapitulated in Fgfrl1 null mice. Dis Model Mech 2:283–294 ArticleCASPubMed Google Scholar
Lazarus JE, Hegde A, Andrade AC, Nilsson O, Baron J (2007) Fibroblast growth factor expression in the postnatal growth plate. Bone 40:577–586 ArticleCASPubMed Google Scholar
Battaglia A, Carey JC, Wright TJ (2001) Wolf-Hirschhorn (4p-) syndrome. Adv Pediatr 48:75–113 CASPubMed Google Scholar
Engbers H, van der Smagt JJ, van `t Slot R, Vermeesch JR, Hochstenbach R, Poot M (2009) Wolf-Hirschhorn syndrome facial dysmorphic features in a patient with a terminal 4p16.3 deletion telomeric to the WHSCR and WHSCR 2 regions. Eur J Hum Genet 17:129–132 ArticleCASPubMed Google Scholar
Holder AM, Klaassens M, Tibboel D, de Klein A, Lee B, Scott DA (2007) Genetic factors in congenital diaphragmatic hernia. Am J Hum Genet 80:825–845 ArticleCASPubMed Google Scholar
Casaccia G, Mobili L, Braguglia A, Santoro F, Bagolan P (2006) Distal 4p microdeletion in a case of Wolf-Hirschhorn syndrome with congenital diaphragmatic hernia. Birth Defects Res A Clin Mol Teratol 76:210–213 ArticleCASPubMed Google Scholar
Lopez Jiminez N, Gerber S, Popovici V, Mirza S, Copren K, Ta L, Shaw GM, Trueb B, Slavotinek AM (2010) Examination of FGFRL1 as a candidate gene for diaphragmatic defects at chromosome 4p16.3 shows that Fgfrl1 null mice have reduced expression of Tpm3, sarcomere genes and Lrtm1 in the diaphragm. Hum Genet 127:325–336 Article Google Scholar
Schild C, Trueb B (2005) Aberrant expression of FGFRL1, a novel FGF receptor, in ovarian tumors. Int J Mol Med 16:1169–1173 CASPubMed Google Scholar
Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K, Fujita T, Fukumoto S, Yamashita T (2006) Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444:770–774 ArticleCASPubMed Google Scholar
Kurosu H, Kuro-O M (2009) The Klotho gene family as a regulator of endocrine fibroblast growth factors. Mol Cell Endocrinol 299:72–78 ArticleCASPubMed Google Scholar
Luedi PP, Dietrich FS, Weidman JR, Bosko JM, Jirtle RL, Hartemink AJ (2007) Computational and experimental identification of novel human imprinted genes. Genome Res 17:1723–1730 ArticleCASPubMed Google Scholar
Falls JG, Pulford DJ, Wylie AA, Jirtle RL (1999) Genomic imprinting: implications for human disease. Am J Pathol 154:635–647 ArticleCASPubMed Google Scholar
Greber B, Lehrach H, Adjaye J (2007) Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal. BMC Dev Biol 7:46 ArticlePubMed Google Scholar
Huang X, Ding L, Bennewith KL, Tong RT, Welford SM, Ang KK, Story M, Le QT, Giaccia AJ (2009) Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol Cell 35:856–867 ArticleCASPubMed Google Scholar