Dual immunoregulatory pathways of 4-1BB signaling (original) (raw)

References

  1. Greenwald RJ, Freeman GJ, Sharpe AH (2005) The B7 family revisited. Annu Rev Immunol 23:515–548
    Article PubMed Google Scholar
  2. Watts TH (2005) The TNF/TNFR family members in costimulation of T cell responses. Annu Rev Immunol 23:23–68
    Article PubMed CAS Google Scholar
  3. Vinay DS, Kwon BS (2006) Immunotherapy targeting 4-1BB and its ligand. Int J Hematol 83:23–28
    Article PubMed CAS Google Scholar
  4. Wong BR, Josien R, Lee SY, Sauter B, Li H-L, Steinman RM, Choi Y (1997) TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor. J Exp Med 186:2075–2080
    Article PubMed CAS Google Scholar
  5. Williamson E, Bilsborough JM, Viney JL (2002) Regulation of mucosal dendritic cell function by receptor activator of NF-κB (RANK)/RANK ligand interactions: impact on tolerance induction. J Immunol 169:3606–3612
    PubMed CAS Google Scholar
  6. Kim N, Takami M, Rho J, Josien R, Choi Y (2002) A novel member of the leukocyte receptor complex regulates osteoclast differentiation. J Exp Med 195:201–209
    PubMed CAS Google Scholar
  7. Kwon BS, Weissman SM (1989) cDNA sequences of two inducible T-cell genes. Proc Natl Acad Sci USA 86:1963–1967
    Article PubMed CAS Google Scholar
  8. Schwarz H, Tuckwell J, Lotz M (1993) A receptor induced by lymphocyte activation (ILA); a new member of the human nerve growth factor/tumor necrosis factor receptor family. Gene 134:295–298
    Article PubMed CAS Google Scholar
  9. Kwon BS, Kim CS, Prystowki MB, Lancki DW, Sabath DE, Pan JL, Weissman SM (1987) Isolation and initial characterization of multiple species of T cell lymphocyte subset cDNA clones. Proc Natl Acad Sci USA 84:2896–2900
    Article PubMed CAS Google Scholar
  10. Pollok KE, Kim YJ, Zhou Z, Hurtado JC, Kim KK, Pickard RT, Kwon BS (1993) Inducible T cell antigen 4-1BB. Analysis of expression and function. J Immunol 150:771–781
    PubMed CAS Google Scholar
  11. Garni-Wagner BA, Lee ZH, Kim YJ, Wilde CE, Kang CY, Kwon BS (1996) 4-1BB is expressed on CD45 RAhi ROhi translational T cells in humans. Cell Immunol 169:91–98
    Article PubMed CAS Google Scholar
  12. Schwarz H, Valbracht J, Tuckwell J, von Kempis J, Lotz M (1995) ILA, the human 4-1BB homologue, is inducible in lymphoid and other cell lineages. Blood 85:1043–1052
    PubMed CAS Google Scholar
  13. Kim KM, Kim HW, Kim JO, Baek KM, Kim JG, Kang CY (2002) Induction of 4-1BB (CD137) expression by DNA damaging agents in human T lymphocytes. Immunology 107:472–479
    Article PubMed CAS Google Scholar
  14. Kim JO, Kim HW, Baek KM, Kang CY (2003) NF-κB and AP-1 regulate activation-dependent CD137 (4-1BB) expression in T cells. FEBS Lett 541:163–170
    Article PubMed CAS Google Scholar
  15. Yamada-Okabe T, Satoh H, Yamada-Okabe H (2003) Thyroid hormone induces the expression of 4-1BB and activation of caspases in thyroid hormone receptor-dependent manner. Eur J Biochem 270:3064–3073
    Article PubMed CAS Google Scholar
  16. Maerten T, Geboes K, De Hertogh G, Shen C, Cadot P, Bullens DM, Van Assche G, Penninckx F, Rutgeerts P, Cueppens JL (2004) Functional expression of 4-1BB (CD137) in the inflammatory tissue in Crohn’s disease. Clin Immunol 112:239–246
    Article PubMed CAS Google Scholar
  17. Jung HW, Choi SW, Choi JI, Kwon BS (2004) Serum concentrations of soluble 4-1BB and 4-1BB ligand correlated with the disease severity in rheumatoid arthritis. Exp Mol Med 36:13–22
    PubMed CAS Google Scholar
  18. Wan YL, Zheng SS, Zhao ZC, Li MW, Jia CK, Zhang H (2004) Expression of co-stimulator 4-1BB molecule in hepatocellular carcinoma and adjacent non-tumor liver tissue, and its possible role in tumor immunity. World J Gastroenterol 10:195–1999
    PubMed CAS Google Scholar
  19. Zhang H, Merchant MS, Chua KS, Khanna C, Helman LJ, Telford B, Ward Y, Summers J, Toresky J, Thomas EK, June CH, Mackall CL (2003) Tumor expression of 4-1BB ligand sustains tumor lytic T cells. Cancer Biol Ther 2:579–586
    PubMed CAS Google Scholar
  20. Wan YL, Zheng SS, Jia CK, Liang TB, Huang DS, Wang WL, Li MW, Zhao ZC (2003) Expression of 4-1BB molecule on peripheral blood T cells in liver transplanted patients and its clinical implication. Hepatobiliary Pancreat Dis Int 2:38–43
    PubMed CAS Google Scholar
  21. Yndestad A, Damas JK, Ger Eiken H, Holm T, Hauh T, Simonsen S, Froland SS, Gullestad, Aukrust P (2002) Increased gene expression of tumor necrosis factor superfamily ligands in peripheral blood mononuclear cells during chronic heart failure. Cardiovasc Res 54:175–182
    Article PubMed CAS Google Scholar
  22. Lim HY, Kim KK, Zhou FC, Yoon JW, Hill JM, Kwon BS (2002) 4-1BB-like molecule is expressed in islet-infiltrating mononuclear cells and in the gray matter of the brain. Cell Biol Int 26:271–278
    Article PubMed CAS Google Scholar
  23. Croft M (2003) Costimulatory members of TNFR family: keys to effective T-cell immunity. Nat Rev Immunol 3:609–620
    Article PubMed CAS Google Scholar
  24. Croft M (2003) Costimulation of T cells by OX-40, 4-1BB, and CD27. Cytokine Growth Factor Rev 14:265–273
    Article PubMed CAS Google Scholar
  25. Takahashi C, Mittler RS, Vella AT (1999) 4-1BB is a bona-fide CD8 T cell survival signal. J Immunol 162:5037–5040
    PubMed CAS Google Scholar
  26. Shuford WW, Klussman K, Tritchler DD, Loo DT, Chalupny, Siadak AW, Brown TJ, Emswiler J, Raecho H, Larsen CP, Pearson TC, Ledbetter JA, Aruffo A, Mittler RS (1997) 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell response. J Exp Med 186:47–55
    Article PubMed CAS Google Scholar
  27. DeBenedette MA, Wen T, Bachman MF, Ohashi PM, Barber BH, Stocking KL, Peschin JJ, Watts TH (1999) Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus. J Immunol 163:4833–4841
    PubMed CAS Google Scholar
  28. Kwon BS, Hurtado JC, Lee ZH, Kwack KB, Seo SK, Choi BK, Koller BH, Wolisi G, Broxmyer HE, Vinay DS (2002) Immune responses in 4-1BB (CD137)-deficient mice. J Immunol 168:5483–5490
    PubMed CAS Google Scholar
  29. Melero I, Johnston JV, Shuford WW, Mittler RS, Chen L (1998) NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies. Cell Immunol 190:167–172
    Article PubMed CAS Google Scholar
  30. Wilcox RA, Tamada K, Strome SE, Chen L (2002) Signaling through NK cell-associated CD137 promotes both helper function for CD8+ cytolytic T cells and responsiveness to IL-2 but not cytolytic activity. J Immunol 169:4230–4236
    PubMed CAS Google Scholar
  31. Kienzel G, von Kempis J (2000) CD137 (ILA/4-1BB), expressed by human monocytes, induces monocyte activation and apoptosis of B lymphocytes. Int Immunol 12:73–82
    Article Google Scholar
  32. Heinisch IV, Daigle I, Knopfli B, Simon HU (2000) CD137 activation abrogates granulocyte-macrophage colony-stimulating factor-mediated anti-apoptosis in neutrophils. Eur J Immunol 30:3441–3446
    Article PubMed CAS Google Scholar
  33. McHugh RS, Matthew JW, Piccrillo CA, Young DA, Shevach EM, Collins M, Byrne MC (2002) CD4+CD25+ immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 16:311–323
    Article PubMed CAS Google Scholar
  34. Wilcox RA, Chapoval AI, Gorski KS, Otsuji M, Shin T, Flies DB, Tamada K, Mittler RS, Tsuchiya H, Pardoll DM, Chen L (2002) Expression of functional CD137 receptor by dendritic cells. J Immunol 168:4262–4267
    PubMed CAS Google Scholar
  35. Zheng G, Wang B, Chen A (2004) The 4-1BB costimulation augments the proliferation of CD4+CD25+ regulatory T cells. J Immunol 173:2428–2434
    PubMed CAS Google Scholar
  36. Choi BK, Bae JS, Choi EM, Kang WJ, Sakaguchi S, Vinay DS, Kwon BS (2004) 4-1BB-dependent inhibition of immunosuppression by activated CD4+CD25+ T cells. J Leukoc Biol 75:785–791
    Article PubMed CAS Google Scholar
  37. Vinay DS, Choi BK, Bae JS, Kim WY, Gebhardt BM, Kwon BS (2004) CD137-deficient mice have reduced NK/NKT cell numbers and function, are resistant to lipopolysaccharide-induced shock syndromes, and have lower IL-4 responses. J Immunol 173:4218–4229
    PubMed CAS Google Scholar
  38. Sun Y, Lin X, Chen HM, Wu Q, Subudhi SK, Chen L, Fu YX (2002) Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis. J Immunol 168:1457–1465
    PubMed CAS Google Scholar
  39. Foell J, Strahotin S, O’Neil SP, McClausland MM, Suwyn C, Haber M, Chander PN, Bapat AS, Yan XJ, Chiorazzi N, Hoffmann MK, Mittler RS (2003) CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB x NZB F1 mice. J Clin Invest 111:1505–1518
    PubMed CAS Google Scholar
  40. Seo SK, Choi JH, Kim YH, Kang WJ, Park HY, Suh JH, Choi BK, Vinay DS, Kwon BS (2004) 4-1BB-mediated immunotherapy of rheumatoid arthritis. Nat Med 10:1088–1094
    Article PubMed CAS Google Scholar
  41. Sun Y, Chen HM, Subudhi SK, Chen J, Koka R, Chen L, Fu YX (2003) Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease. Nat Med 8:1405–1413
    Article Google Scholar
  42. Kim J, Choi WS, La S, Suh JH, Kim BS, Cho HR, Kwon BS, Kwon B (2004) Stimulation with 4-1BB (CD137) inhibits chronic-graft-versus-host disease by inducing activation-induced cell death of donor CD4+ T cells. Blood 105:2206–2213
    Article PubMed Google Scholar
  43. Cervara R (2001) The epidemiology and significance of autoimmune diseases in health care. Scand J Clin Lab Invest 61:27–35
    Article Google Scholar
  44. Sun Y, Blink SE, Chen JH, Fu YX (2005) Regulation of follicular dendritic cell networks by activated T cells: the role of CD137 signaling. J Immunol 175:884–890
    PubMed CAS Google Scholar
  45. Sytwu HK, Lin WD, Roffler SR, Hung JT, Sung HS, Wang CH, Cheng TL, Tsou SC, His SC, Shen KL (2003) Anti-4-1BB-based immunotherapy for autoimmune diabetes: lessons from a transgenic non-obese diabetic (NOD) model. J Autoimmun 21:247–254
    Article PubMed CAS Google Scholar
  46. Kwon B, Lee HW, Kwon BS (2002) New insights into the role of 4-1BB in immune responses: beyond CD8+ T cells. Trends Immunol 23:378–380
    Article PubMed CAS Google Scholar
  47. Homann D, Jahreis A, Wolfe T, Hughes A, Coon B, van Stipdonk MJB, Prilliman KR, Schoenbeger SP, von Herrath MG (2002) CD40L blockade prevents autoimmune diabetes by induction of bitypic NK/DC regulatory cells. Immunity 16:403–415
    Article PubMed CAS Google Scholar
  48. Chan CW, Crafton E, Fan H-N, Flook J, Yoshimura K, Skarica M, Brockstedt D, Dubensky TW, Stins M, Lanier LL, Pardoll DM, Housseau F (2006) Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity. Nat Med 12:207–213
    Article PubMed CAS Google Scholar
  49. Taieb J, Chaput N, Menard C, Apetoh L, Ullrich E, Bonmort M, Pequignot M, Casares N, Terme M, Flament C, Opolon P, Lecluse Y, Metivier D, Tomasello E, Vivier E, Ghiringhelli F, Martin F, Klatzmann D, Poynard T, Tursz T, Raposo G, Yagita H, Ryffel B, Kroemer, Zitvgel L (2006) A novel dendritic cell subset in tumor immunosurveillance. Nat Med 12: 214–219
    Article PubMed CAS Google Scholar
  50. Bertram EM, Dawicki W, Watts TH (2004) Role of T cell costimulation in anti-viral immunity. Sem Immunol (2004) 16:185–196
    Article CAS Google Scholar
  51. Halstead ES, Mueller YM, Altman JD, Katsikis PD (2002) In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses. Nat Immunol 168:5483–5490
    Google Scholar
  52. Bertram EM, Dawicki W, Sedgmen B, Bramson JL, Lynch DH, Watts TH (2004) A switch in costimulation from a CD28 to 4-1BB during primary versus secondary CD8 T cell response to influenza virus in vivo. J Immunol 15:981–988
    Google Scholar
  53. Maus MV, Thomas AK, Leonard DGB, Allman D, Addya K, Schlienger K, Riley JL, June CH (2002) Expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB. Nat Biotech 20:143–148
    Article CAS Google Scholar
  54. Arribillaga L, Sarobe P, Arina A, Gorraiz M, Borras-Cuesta F, Ruiz J, Prieto J, Chen L, Melero I, Lasarte JJ (2005) Enhancement of CD4 and CD8 immunity by anti-CD137 (4-1BB) monoclonal antibodies during hepatitis C vaccination with recombinant adenovirus. Vaccine 23:3493–3499
    Article PubMed CAS Google Scholar
  55. Kim YH, Seo SK, Choi BK, Kang WJ, Kim CH, Lee SK, Kwon BS (2005) 4-1BB costimulation enhances HSV-1-specific CD8+ T cell responses by the induction of CD11c+CD8+ T cells. Cell Immunol 238:76–86
    Article PubMed CAS Google Scholar
  56. Melero I, Shuford WW, Newby SA, Aruffo A, Ledbetter JA, Hellstrom KE, Mittler RS, Chen L (1997) Monoclonal antibodies against 4-1BB T-cell activation molecule eradicate established tumors. Nat Med 3:682–685
    Article PubMed CAS Google Scholar
  57. Tirapu I, Arina A, Mazzolini G, Duarte M, Alfaro C, Feiji E, Qian C, Chen L, Prieto J, Melero I (2004) Improving efficacy of interleukin-12-transfected dendritic cells injected into murine colon cancer with anti-CD137 monoclonal antibodies and alloantigens. Int J Cancer 110:51–60
    Article PubMed CAS Google Scholar
  58. Xu DP, Sauter BV, Huang TG, Meseck M, Woo SL, Chen SH (2005) The systemic administration of Ig-4-1BB ligand in combination with IL-12 gene transfer eradicates hepatic colon carcinoma. Gen Ther 12:1526–1533
    Article CAS Google Scholar
  59. Schuler G, Steinman RM (1997) Dendritic cells as adjuvants for immune-mediated resistance to tumors. J Exp Med 186:1183–1187
    Article PubMed CAS Google Scholar
  60. Pilon-Thomas SA, Verhaegen ME, Mule JJ (2005) Dendritic cell-based therapeutics for breast cancer. Breast Dis 20:65–71
    Google Scholar
  61. Ito F, Li Q, Shreiner AB, Okuyama R, Jure-Kunkel MN, Tietz-Tennenbaum S, Chang AE (2004) Anti-CD137 monoclonal antibody administration augments the anti tumor efficacy of dendritic cell-based vaccines. Cancer Res 64:8411–8419
    Article PubMed CAS Google Scholar
  62. Ju SA, Lee SC, Kwon TH, Heo SK, Park SM, Paek HN, Suh JH, Cho HR, Kwon B, Kwon BS, Kim BS (2005) Immunity to melanoma mediated by 4-1BB is associated with enhanced activity of tumor-infiltrating lymphocytes. Immunol Cell Biol 83:344–351
    Article PubMed CAS Google Scholar
  63. Ye Z, Hellstrom I, Hayden-Ledbetter M, Dahlin A, Ledbetter JA, Hellstrom KE (2002) Gene therapy for cancer using single-chain Fv fragments specific for 4-1BB. Nat Med 8:343–348
    Article PubMed CAS Google Scholar
  64. Sabel MS, Conway TF, Chen FA, Bankert RB (2000) Monoclonal antibodies directed against the T-cell activation molecule CD137 (interleukin-A or 4-1BB) block human lymphocyte-mediated suppression of tumor xenografts in severe combined immunodeficient mice. J Immunother 23:362–368
    Article PubMed CAS Google Scholar
  65. Mittler RS, Bailey TS, Klussman K, Trailsmith MD, Hoffmann MK (1999) Anti-4-1BB monoclonal antibodies abrogate T-cell-dependent humoral immune responses in vivo through the induction of helper T cell anergy. J Exp Med 190:1535–1540
    Article PubMed CAS Google Scholar
  66. Hong HJ, Lee JW, Park SS, Kang YJ, Chang SY, Kim KM, Kim JO, Murthy KK, Payne JS, Yoon SK, Park MJ, Kim IC, Kim JG, Kang CY (2000) A humanized anti-4-1BB monoclonal antibody suppresses antigen-induced humoral immune response in nonhuman primates. J Immunother 23:613–621
    Article PubMed CAS Google Scholar
  67. Grohmann U, Fallarino F, Puccetti P (2003) Tolerance, DCs and tryptophan: much ado about IDO. Trends Immunol 24:242–249
    Article PubMed CAS Google Scholar
  68. Mellor A, Munn DH (2004) IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol 4:762–774
    Article PubMed CAS Google Scholar

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